Protein Information

Name epidermal growth factor
Synonyms EGF; Epidermal growth factor; Pro epidermal growth factor; Pro epidermal growth factor precursor; URG; Urogastrone; epidermal growth factor (beta urogastrone); Epidermal growth factors…

Compound Information

Name chlordane
CAS

Reference List

PubMed Abstract RScore(About this table)
12450323 Cossette LJ, Gaumond I, Martinoli MG: Combined effect of xenoestrogens and growth factors in two estrogen-responsive cell lines. Endocrine. 2002 Aug;18(3):303-8.

Cells were treated with two known xenoestrogens, endosulfan and chlordane, alone or in the presence of insulin-like growth factor-1 and epidermal growth factor, respectively, and their growth was measured using the 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxyanilide proliferation assay.
6(0,0,1,1) Details
11532878 Rivedal E, Opsahl H: Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells. Carcinogenesis. 2001 Sep;22(9):1543-50.

The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), chlordane and the growth factor epidermal growth factor (EGF) are potent inhibitors of GJIC in several cell types, including the rat liver epithelial cell line IAR6.1.
31(0,1,1,1) Details