| Name | estrogen receptor |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | chlordane |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16626760 | Lemaire G, Mnif W, Mauvais P, Balaguer P, Rahmani R: Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 2006 Aug 15;79(12):1160-9. Epub 2006 Mar 27. In our model, fifteen of the tested pesticides were found to agonize the ERalpha-mediated transcription in a dose-dependent manner and DDT, trans-nonachlor, chlordane, fenvalerate and toxaphene were also capable to activate ERbeta. |
86(1,1,1,6) | Details |
| 12030773 | Rousseau J, Cossette L, Grenier S, Martinoli MG: Modulation of prolactin expression by xenoestrogens. Gen Comp Endocrinol. 2002 Apr;126(2):175-82. Together, our results suggest that endosulfan and chlordane could indeed modulate an -inducible gene such as PRL, possibly acting via second messenger-mediated cellular mechanisms instead of solely competing with estrogens for the nuclear estrogen receptor sites. |
81(1,1,1,1) | Details |
| 9407589 | Wade MG, Desaulniers D, Leingartner K, Foster WG: Interactions between endosulfan and dieldrin on -mediated processes in vitro and in vivo. Reprod Toxicol. 1997 Nov-Dec;11(6):791-8. Recent in vitro data suggest that the interaction between some weakly estrogenic organochlorines, dieldrin, endosulfan, toxaphene, and chlordane, causes a synergistic increase in their estrogenic potency, an effect due to joint action on estrogen receptors (ER). |
31(0,1,1,1) | Details |
| 10330684 | Legler J, van den Brink CE, Brouwer A, Murk AJ, van der Saag PT, Vethaak AD, van der Burg B: Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicol Sci. 1999 Mar;48(1):55-66. Determination of interactive effects of the (pseudo-) estrogens nonylphenol, o,p'DDT, chlordane, endosulfan, dieldrin, and methoxychlor revealed that, in combination with 3 pM E2, (pseudo-) estrogens were additive. |
3(0,0,0,3) | Details |
| 20351196 | Miao L, Shi J, Wang CY, Zhu Y, Du X, Jiao H, Mo Z, Klocker H, Lee C, Zhang J: Estrogen Receptor-Related Receptor {alpha} Mediates Up-Regulation of Aromatase Expression by in Prostate Stromal Cells. Mol Endocrinol. 2010 Mar 29. Suppression of ERRalpha activity by chlordane (an antagonist of ERRalpha) or small interfering RNA knockdown of ERRalpha blocked the increase of expression and promoter activity of aromatase induced by |
2(0,0,0,2) | Details |
| 9168004 | Arnold SF, Vonier PM, Collins BM, Klotz DM, Guillette LJ Jr, McLachlan JA: In vitro synergistic interaction of alligator and human estrogen receptors with combinations of environmental chemicals. Environ Health Perspect. 1997 Apr;105 Suppl 3:615-8. The environmental chemicals included the insecticide chlordane, which has no estrogenic activity, and the pesticides dieldrin and toxaphene, which have very weak estrogenic activity. |
2(0,0,0,2) | Details |
| 9118873 | Vonier PM, Crain DA, McLachlan JA, Guillette LJ Jr, Arnold SF: Interaction of environmental chemicals with the and progesterone receptors from the oviduct of the American alligator. Environ Health Perspect. 1996 Dec;104(12):1318-22. To determine whether environmental chemicals had the potential to function as exogenous hormones in the American alligator, we examined the ability of chemicals to bind the estrogen receptor (aER) and progesterone receptor (aPR) in a protein extract prepared from the oviduct of the alligator. To test the effect of chemicals identified in alligator eggs from Lake Apopka on [3H] 17 beta- binding, we mixed these chemicals at concentrations measured in eggs in the competition binding assay. 2,2-bis (4-chlorophenyl)-N-(methoxymethyl) acetamide (p,p'-DDD) and trans-nonachlor, both found in Lake Apopka, interacted with aER, whereas others such as chlordane and toxaphene did not. |
1(0,0,0,1) | Details |
| 10493499 | Yang C, Chen S: Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res. 1999 Sep 15;59(18):4519-24. Estrogen-related receptor (ERR) alpha-1 shares a high amino acid sequence homology with estrogen receptor alpha. |
2(0,0,0,2) | Details |
| 16515477 | Ariazi EA, Jordan VC: -related receptors as emerging targets in cancer and metabolic disorders. Curr Top Med Chem. 2006;6(3):203-15. While estrogen receptor (ER)-targeted therapeutics have clearly been a success in the treatment of breast cancer, the orphan -related receptors (ERRs) represent novel targets for future development. The organochlorine pesticides toxaphene and chlordane, and the synthetic compound XCT790 antagonize ERRalpha. |
2(0,0,0,2) | Details |
| 12450323 | Cossette LJ, Gaumond I, Martinoli MG: Combined effect of xenoestrogens and growth factors in two -responsive cell lines. Endocrine. 2002 Aug;18(3):303-8. Several crosstalks between the estrogen receptor and other signaling pathways may influence the estrogenic stimulation of cell growth. Cells were treated with two known xenoestrogens, endosulfan and chlordane, alone or in the presence of insulin-like growth factor-1 and epidermal growth factor, respectively, and their growth was measured using the 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxyanilide proliferation assay. |
1(0,0,0,1) | Details |
| 10667634 | Arcaro KF, Yang Y, Vakharia DD, Gierthy JF: Toxaphene is antiestrogenic in a human breast-cancer cell assay. J Toxicol Environ Health A. 2000 Feb 11;59(3):197-210. Toxaphene was also tested for its ability (1) to bind the estrogen receptor (ER) in a competitive binding assay using recombinant human ERalpha (rhER) and in a whole-cell competitive ER binding assay, and (2) to alter the catabolism of E2 in MCF-7 cell cultures. Results from the MCF-7 focus assay showed: (1) Toxaphene alone was not estrogenic between the concentrations of 0.5 nM and 10 microM, (2) toxaphene in binary combinations with chlordane, dieldrin, or endosulfan (alpha or beta) was not estrogenic, and (3) toxaphene was weakly antiestrogenic (it reduced the number of foci induced by 0.1 nM and 0.01 nM E2). |
1(0,0,0,1) | Details |
| 9558340 | Massaad C, Coumoul X, Sabbah M, Garlatti M, Redeuilh G, Barouki R: Properties of overlapping EREs: synergistic activation of transcription and cooperative binding of ER. Biochemistry. 1998 Apr 28;37(17):6023-32. In gel retardation assays, this sequence forms a low-mobility complex that migrates like an estrogen receptor tetramer. This synergistic effect was observed using either the natural hormone (17- or xenoestrogens red, chlordane). |
1(0,0,0,1) | Details |
| 15589975 | Lemaire G, Balaguer P, Michel S, Rahmani R: Activation of receptor-dependent transcription by organochlorine pesticides. Toxicol Appl Pharmacol. 2005 Jan 1;202(1):38-49. Five organochlorine pesticides, namely, chlordane, dieldrin, aldrin, endrin, and endosulfan, activate human receptor (RAR)-mediated gene transcription via a response element (RARE). |
0(0,0,0,0) | Details |
| 9075711 | Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S: Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology. 1997 Apr;138(4):1520-7. Treatment with 10 (-6)-10 (-4) M chlordane, dieldrin, toxaphene, or an equimolar mixture of dieldrin/toxaphene did not induce activity, whereas 10 (-4) M endosulfan caused a 2000-fold increase in beta-gal activity. |
0(0,0,0,0) | Details |