Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name chlordane
CAS

Reference List

PubMed Abstract RScore(About this table)
6226517 Drummond L, Chetty KN, Desaiah D: Changes in brain ATPases in rats fed on chlordane mixed with iron-sufficient and deficient diet. Drug Chem Toxicol. 1983;6(3):259-66.

The brain O.S Mg2+ ATPase was also reduced in rats receiving chlordane.
82(1,1,1,2) Details
159816 Verma SR, Bansal SK, Gupta AK, Dalela RC: Sensitivity of ATPase system in certain tissues of Labeo rohita and Saccobranchus fossilis following in vitro treatment with chlordane. Environ Res. 1979 Jun;19(1):14-22.
6(0,0,1,1) Details
155483 Verma SR, Bansal SK, Gupta AK, Dalela RC: In vivo effect on ATPase in certain tissues of Labeo rohita and Saccobranchus fossilis, following chronic chlordane intoxication. Bull Environ Contam Toxicol. 1978 Dec;20(6):769-77.
6(0,0,1,1) Details
2035178 Ogata M, Izushi F: Effects of chlordane on parameters of liver and muscle toxicity in man and experimental animals. Toxicol Lett. 1991 May;56(3):327-37.

0(0,0,0,0) Details
6136149 Lundholm CE, Mathson K: The inhibitory effect of some chlorinated hydrocarbon pesticides on the ATP-dependent Ca2+ binding of the particulate fraction of the eggshell gland mucosa cells. Acta Pharmacol Toxicol. 1983 May;52(5):390-4.

The activity of a Ca2+-Mg2+-activated ATPase in the homogenate was also decreased on administration of DDE in vivo.
Several of the investigated compounds, namely toxaphene, chlordane, p-p'-DDD, o-p'-DDE, p-p'-DDT, methoxychlor and PCB (Arochlor 1242), had a similar IC50 to inhibit the Ca2+ binding as p-p'-DDE.
3(0,0,0,3) Details
7319725 Chatterjee K, Banerjee SK, Tiwari R, Mazumdar K, Bhattacharyya A, Chatterjee GC: Studies on the protective effects of L-ascorbic acid in chronic chlordane toxicity. Int J Vitam Nutr Res. 1981;51(3):254-65.

It inhibits the activities of acid and alkaline phosphatases, SDH and Mg2+-ATPase of both hepatic and renal tissues.
1(0,0,0,1) Details