| Name | CYP2B |
|---|---|
| Synonyms | CYP2B; CYP2B7; CYP2B7P; CYP2B protein; CYP2B7P1; CYP2B7P1 protein; CYP2B7P1 proteins |
| Name | chlordane |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7473857 | Nims RW, Lubet RA: Induction of cytochrome P-450 in the Norway rat, Rattus norvegicus, following exposure to potential environmental contaminants. J Toxicol Environ Health. 1995 Nov;46(3):271-92. In contrast, the chlorinated hydrocarbon pesticides, such as DDT, dieldrin, chlordane, and mirex, cause almost exclusively the induction of isoforms of the CYP2B (and to a lesser extent the CYP3A) subfamilies. |
32(0,1,1,2) | Details |
| 15649640 | Dehn PF, Allen-Mocherie S, Karek J, Thenappan A: Organochlorine insecticides: impacts on human HepG2 cytochrome P4501A, 2B activities and levels. Toxicol In Vitro. 2005 Mar;19(2):261-73. This study examined the effects of the organochlorine (OC) insecticides chlordane, o,p'-DDT, dieldrin, endosulfan, kepone, methoxychlor, and toxaphene on human HepG2 cytochrome P450 (1A-EROD and 2B-PROD) activities and (GSH) levels. These results support findings of OC insecticides inducing CYP1A, 2B in rats, with CYP2B responses more important. |
1(0,0,0,1) | Details |
| 12297372 | Ruus A, Sandvik M, Ugland KI, Skaare JU: Factors influencing activities of biotransformation enzymes, concentrations and compositional patterns of organochlorine contaminants in members of a marine food web. Aquat Toxicol. 2002 Nov 13;61(1-2):73-87. The accumulation of polychlorinated biphenyls (PCBs; 34 congeners), sigmaDDT (p,p'-DDT, o,p'-DDT, p,p'-DDD, o,p'-DDD and p,p'-DDE), chlordanes (sigmaCHL; trans-chlordane, cis-chlordane, trans-nonachlor, cis-nonachlor and oxychlordane), hexachlorocyclohexanes (sigmaHCH; alpha-, beta- and gamma-isomers), hexachlorobenzene (HCB) and mirex was investigated in members of a marine food web from the Hvaler and Torbjornskaer archipelago, south-eastern Norway. High correlations between EROD and PROD activities were found in all species, suggesting a single, common catalyst, CYP1A, and render the PROD assay questionable as biomarker for CYP2B inducers in marine wildlife. |
1(0,0,0,1) | Details |