| Name | GABA receptor (protein family or complex) |
|---|---|
| Synonyms | GABA receptor; GABA receptors; GABA(A) receptor; GABA(A) receptors; Gamma aminobutyric acid receptor; Gamma aminobutyric acid receptors |
| Name | heptachlor |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1694587 | Lummis SC, Buckingham SD, Rauh JJ, Sattelle DB: Blocking actions of heptachlor at an insect central nervous system GABA receptor. Proc R Soc Lond B Biol Sci. 1990 May 22;240(1297):97-106. The actions of the polychlorocycloalkane insecticide heptachlor, and its epoxide metabolite, were examined on GABA receptors in insects and vertebrates. |
194(2,3,3,4) | Details |
| 9257933 | Rauh JJ, Benner E, Schnee ME, Cordova D, Holyoke CW, Howard MH, Bai D, Buckingham SD, Hutton ML, Hamon A, Roush RT, Sattelle DB: Effects of [3H]-BIDN, a novel bicyclic dinitrile radioligand for -gated channels of insects and vertebrates. Br J Pharmacol. 1997 Aug;121(7):1496-505. A variety of (GABA) receptor convulsants, including the insecticides heptachlor (IC50, 35 +/- 3 nM) and dieldrin (IC50, 93 +/- 7 nM), displaced [3H]-BIDN from rootworm membranes. |
7(0,0,1,2) | Details |
| 1722072 | Narahashi T: Transmitter-activated ion channels as the target of chemical agents. Adv Exp Med Biol. 1991;287:61-73. Lindane and the cyclodienes dieldrin, endrin, heptachlor-epoxide, and isobenzan suppressed the -activated current. It seems that general anesthetics have a specific affinity for the GABA receptor-channel complex. |
2(0,0,0,2) | Details |
| 3009836 | Abalis IM, Eldefrawi ME, Eldefrawi AT: Effects of insecticides on -induced influx into rat brain microsacs. J Toxicol Environ Health. 1986;18(1):13-23. The actions of different insecticides known to affect binding of ligands to (GABA) receptors were studied on the function of GABAA receptors in rat brain as assayed by -induced 36Cl- influx into membrane microsacs. The -induced 36Cl- flux was inhibited by several cyclodienes and gamma-hexachlorocyclohexane (gamma-BHC) with the following order of decreasing potency: endosulfan I greater than endrin greater than endosulfan II greater than dieldrin greater than heptachlor epoxide greater than gamma-BHC greater than heptachlor. |
1(0,0,0,1) | Details |