| Name | vesicular monoamine transporter 2 |
|---|---|
| Synonyms | Monoamine transporter; SLC18A2; SVAT; SVMT; Solute carrier family 18 member 2; Synaptic vesicular amine transporter; Synaptic vesicular amine transporter brain; Synaptic vesicular monoamine transporter brain… |
| Name | heptachlor |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10499361 | Miller GW, Kirby ML, Levey AI, Bloomquist JR: Heptachlor alters expression and function of dopamine transporters. . Neurotoxicology. 1999 Aug;20(4):631-7. Here we report that subchronic administration of the organochlorine insecticide heptachlor (0, 3, 6, 9, or 12 mg/kg given 3 times over a 2 week period) leads to a pronounced increase in both the plasma membrane transport of and the expression of the plasma membrane dopamine transporter (DAT), as well as the vesicular monoamine transporter (VMAT2) in the striatum of C57BL mice. |
69(0,2,3,4) | Details |
| 18577399 | Richardson JR, Caudle WM, Wang MZ, Dean ED, Pennell KD, Miller GW: Developmental heptachlor exposure increases susceptibility of neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in a gender-specific manner. Neurotoxicology. 2008 Sep;29(5):855-63. Epub 2008 Jun 5. Exposure of pregnant mice to heptachlor led to increased levels of the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) levels at both the protein and mRNA level in their offspring. |
7(0,0,1,2) | Details |
| 15849736 | Greer CL, Grygoruk A, Patton DE, Ley B, Romero-Calderon R, Chang HY, Houshyar R, Bainton RJ, Diantonio A, Krantz DE: A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of and J Neurobiol. 2005 Sep 5;64(3):239-58. Using in vitro transport assays, we show that DVMAT-A recognizes DA, 5HT, and as substrates, and similar to mammalian VMAT homologs, is inhibited by the drug reserpine and the environmental toxins 2,2,4,5,6-pentachlorobiphenyl and heptachlor. |
2(0,0,0,2) | Details |
| 16112329 | Caudle WM, Richardson JR, Wang M, Miller GW: Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum. Neurotoxicology. 2005 Aug;26(4):721-8. In this study, we examined the effects of developmental exposure to heptachlor on DAT, and other key components of the dopaminergic system, including the vesicular monoamine transporter 2 (VMAT2), tyrosine hydroxylase (TH), and aromatic amino acid decarboxylase (AADC). |
6(0,0,1,1) | Details |