Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name heptachlor
CAS

Reference List

PubMed Abstract RScore(About this table)
15620088 Sheweita SA: Carcinogen-metabolizing enzymes and insecticides. J Environ Sci Health B. 2004;39(5-6):805-18.

The present study was under taken to demonstrate the effect of some commonly used insecticides on the activity of cytochrome P450 system including cytochrome b5, aryl hydrocarbon [benzo (a) pyrene] hydroxylase (AHH), N-nirosodimethylamine N-demethylase I [NDMA-dI] and NADPH-cytochrome c reductase as phase I of drug oxidation.
In addition, the activity of glutathione S-transferase (GST), glutathione reductase (GR), and the level of glutathione (GSH) were determined in the liver of male mice after oral administration of sumithion, dursban, chlordane, methoxychlor, heptachlor epoxide, and lindane as single (24h) or as repeated doses for six consecutive days.
2(0,0,0,2) Details
14678745 Okoumassoun LE, Averill-Bates D, Marion M, Denizeau F: Possible mechanisms underlying the mitogenic action of heptachlor in rat hepatocytes. Toxicol Appl Pharmacol. 2003 Dec 15;193(3):356-69.

Moreover, these results indicate that like many tumor promoters, heptachlor strongly inhibited TGFbeta-induced apoptosis and cytochrome c release into the cytosol.
31(0,1,1,1) Details
824158 Wade AE, Norred WP: Effect of dietary lipid on drug-metabolizing enzymes. Fed Proc. 1976 Nov;35(13):2475-9.


Male rats fed diet containing 3% corn oil for 3 weeks metabolized hexobarbital, aniline and heptachlor significantly faster than those fed fat-free diet.
0(0,0,0,0) Details
8117673 Andersen JF, Utermohlen JG, Feyereisen R: Expression of house fly CYP6A1 and NADPH-cytochrome P450 reductase in Escherichia coli and reconstitution of an insecticide-metabolizing P450 system. Biochemistry. 1994 Mar 1;33(8):2171-7.


The reconstituted system was effective in the epoxidation of the cyclodiene insecticides aldrin and heptachlor, with turnover rates of 12 and 34 min-1, respectively.
0(0,0,0,0) Details