| Name | cytochrome P450 reductase |
|---|---|
| Synonyms | CPR; CYPOR; Cytochrome P 450 reductase; Cytochrome P450 reductase; NADPH cytochrome P450 reductase; NADPH cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450R… |
| Name | heptachlor |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8900138 | Guzov VM, Houston HL, Murataliev MB, Walker FA, Feyereisen R: Molecular cloning, overexpression in Escherichia coli, structural and functional characterization of house fly cytochrome b5. J Biol Chem. 1996 Oct 25;271(43):26637-45. The cytochrome b5 is reduced by house fly cytochrome P450 reductase in a reconstituted system at a high rate (5.5 s-1), and it stimulates heptachlor epoxidation when reconstituted with house fly cytochrome P450 reductase, cytochrome P450 6A1, phospholipid, and detergent. |
31(0,1,1,1) | Details |
| 8117673 | Andersen JF, Utermohlen JG, Feyereisen R: Expression of house fly CYP6A1 and NADPH-cytochrome P450 reductase in Escherichia coli and reconstitution of an insecticide-metabolizing P450 system. Biochemistry. 1994 Mar 1;33(8):2171-7. The reconstituted system was effective in the epoxidation of the cyclodiene insecticides aldrin and heptachlor, with turnover rates of 12 and 34 min-1, respectively. |
2(0,0,0,2) | Details |
| 9407006 | Dunkov BC, Guzov VM, Mocelin G, Shotkoski F, Brun A, Amichot M, Ffrench-Constant RH, Feyereisen R: The Drosophila cytochrome P450 gene Cyp6a2: structure, localization, heterologous expression, and induction by phenobarbital. DNA Cell Biol. 1997 Nov;16(11):1345-56. The CYP6A2 protein produced in this system metabolized aldrin and heptachlor to their epoxides and metabolized the insecticide diazinon by desulfuration to diazoxon and by oxidative ester cleavage to 2-isopropyl-4-methyl-6-hydroxypyrimidine. Metabolism in lysates of cells infected with recombinant baculovirus was greatly enhanced by the addition of purified housefly NADPH cytochrome P450 reductase and cytochrome b5. |
1(0,0,0,1) | Details |