| Name | estrogen receptor |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | heptachlor |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19101654 | Davis LK, Visitacion N, Riley LG, Hiramatsu N, Sullivan CV, Hirano T, Grau EG: Effects of o,p'-DDE, heptachlor, and 17beta- on vitellogenin gene expression and the growth hormone/insulin-like growth factor-I axis in the tilapia, Oreochromis mossambicus. Comp Biochem Physiol C Toxicol Pharmacol. 2009 May;149(4):507-14. Epub 2008 Dec 6. Treatment with o,p'-DDE and heptachlor as well as E (2) increased ERalpha and ERbeta transcript levels. |
7(0,0,1,2) | Details |
| 9392618 | Shekhar PV, Werdell J, Basrur VS: Environmental stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines. J Natl Cancer Inst. 1997 Dec 3;89(23):1774-82. Among the PCBs, Heptachlor is estrogenic (in transient reporter assays; P < or =.001), whereas Aroclor 1221 and Aroclor 1254, both individually and in combination, are only weakly estrogenic. |
6(0,0,0,6) | Details |
| 12505301 | Guillette LJ Jr, Vonier PM, McLachlan JA: Affinity of the alligator estrogen receptor for serum pesticide contaminants. Toxicology. 2002 Dec 27;181-182:151-4. The most effective compounds were heptachlor epoxide and heptachlor, with IC50 of 19.4 and 26.7 microM, respectively. |
2(0,0,0,2) | Details |
| 16242299 | Wong PS, Matsumura F: Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range. Toxicol In Vitro. 2006 Apr;20(3):382-94. Epub 2005 Oct 19. We observed concentration dependent ER mediated cell proliferation in BG-1 cells using heptachlor epoxide (HE), beta-hexachlorohexane (beta-HCH), and endosulfan (Endo). |
2(0,0,0,2) | Details |
| 12167306 | Okoumassoun LE, Averill-Bates D, Gagne F, Marion M, Denizeau F: Assessing the estrogenic potential of organochlorine pesticides in primary cultures of male rainbow trout (Oncorhynchus mykiss) hepatocytes using vitellogenin as a biomarker. Toxicology. 2002 Sep 16;178(3):193-207. Non-toxic levels of these compounds competed with E (2) for binding to the estrogen receptor. The aim of this study was to assess the estrogenic activity of the organochlorine pesticides o,p'-DDT, dieldrin, aldrin, heptachlor, mirex and DDT in rainbow trout hepatocyte cultures using vitellogenin (Vtg) as the biomarker. |
1(0,0,0,1) | Details |
| 10789375 | Vinggaard AM, Breinholt V, Larsen JC: Screening of selected pesticides for oestrogen receptor activation in vitro. Food Addit Contam. 1999 Dec;16(12):533-42. These were: bromopropylate, chlorfenvinphos, chlorobenzilate, dicofol, heptachlor, and imazalil. |
0(0,0,0,0) | Details |