Protein Information

Name bcl 2
Synonyms Apoptosis regulator Bcl 2; B cell CLL/lymphoma 2; B cell lymphoma protein 2 alpha; B cell lymphoma protein 2 alpha isoform; BCL2; Bcl 2; B cell CLL/lymphoma 2s; B cell lymphoma protein 2 alphas…

Compound Information

Name heptachlor
CAS

Reference List

PubMed Abstract RScore(About this table)
10757037 Chuang LF, Rought SE, Chuang RY: Differential regulation of the major cyclin-dependent kinases, cdk2 and cdc2, during cell cycle progression in human lymphocytes exposed to heptachlor. In Vivo. 1999 Nov-Dec;13(6):455-61.

The altered cell cycle progression may trigger the cell's apoptotic potential, as indicated by the reduced amount of Bcl-2 synthesized inside heptachlor-treated cells.
81(1,1,1,1) Details
14678745 Okoumassoun LE, Averill-Bates D, Marion M, Denizeau F: Possible mechanisms underlying the mitogenic action of heptachlor in rat hepatocytes. Toxicol Appl Pharmacol. 2003 Dec 15;193(3):356-69.

The levels of the anti-apoptotic protein Bcl-2 were also increased in the presence of heptachlor.
6(0,0,1,1) Details