| Name | protein kinase C (protein family or complex) |
|---|---|
| Synonyms | Protein kinase C; PKC |
| Name | heptachlor |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14678745 | Okoumassoun LE, Averill-Bates D, Marion M, Denizeau F: Possible mechanisms underlying the mitogenic action of heptachlor in rat hepatocytes. Toxicol Appl Pharmacol. 2003 Dec 15;193(3):356-69. Exposure to heptachlor led to activation of protein kinase C mitogenactivated protein kinases. |
31(0,1,1,1) | Details |
| 11170310 | Hansen ME, Matsumura F: Down-regulation of particulate protein kinase Cepsilon and up-regulation of nuclear activator protein-1 DNA binding in liver following in vivo exposure of B6C3F1 male mice to heptachlor epoxide. J Biochem Mol Toxicol. 2001;15(1):1-14. The effects of in vivo administration of the cyclodiene tumor promoter heptachlor epoxide on mouse liver protein kinase C were studied in male B6C3F1 mice by protein kinase C activity assays and Western blotting under conditions known to increase the incidence of hepatocellular carcinoma because protein kinase C is thought to be critical in phorbol ester-induced tumor promotion. |
18(0,0,3,3) | Details |
| 2706741 | Moser GJ, Smart RC: Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity. Carcinogenesis. 1989 May;10(5):851-6. Chlordane, kepone, toxaphene, heptachlor, 2,2-bis (4-chlorophenyl)-1,1-dichloroethane, the polychlorinated biphenyl Aroclor 1254, aldrin, 2,2-bis (4-chlorophenyl)-1,1,1-trichloroethane (DDT) and gamma-hexachlorocyclohexane (lindane) were the most potent stimulators of PKC activity. |
3(0,0,0,3) | Details |
| 12242688 | Moya de Juri MG, Magnarelli De Potas G, Pechen de D'Angelo AM: Alteration of thrombine-signaling mechanism by heptachlor in human platelets. J Biochem Mol Toxicol. 2002;16(4):189-96. Experiments showed that 10 microM increased protein Kinase C (PKC) activity and phosphatidylinositolbiphosphate and phosphorylation. |
1(0,0,0,1) | Details |
| 19526567 | Magnarelli G, Souza MS, de D'Angelo AM: Heptachlor and o-p'DDT effects on protein kinase activities associated with human placenta particulate fractions. J Biochem Mol Toxicol. 2009 May;23(3):185-92. By contrast, protein kinase C activity was reduced by 10 microM HC and o-p' DDT (40% and 52%, respectively). |
1(0,0,0,1) | Details |