Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name HHDN
CAS

Reference List

PubMed Abstract RScore(About this table)
1685399 Borlakoglu JT, Wilkins JP, Quick MP, Walker CH, Dils RR: Metabolism of [14C] 4-chlorobiphenyl by hepatic microsomes isolated from razorbills, pigeons and rats. Comp Biochem Physiol C. 1991;99(3):287-91.

A comparison of the hepatic drug metabolising enzyme system of razorbills and pigeons showed similar concentrations of cytochrome P-450, cytochrome b5 and comparable catalytic activities of cytochrome P-450-dependent monooxygenase, when assessed for HHDN epoxidase, PROD, EROD and the Phase II enzymes glutathiones-S-transferase, but were significantly lower, when compared with rats.
7(0,0,1,2) Details
2866919 Ronis MJ, Walker CH: Species variations in the metabolism of liposoluble organochlorine compounds by hepatic microsomal monooxygenase: comparative kinetics in four vertebrate species. Comp Biochem Physiol C. 1985;82(2):445-9.

Lineweaver-Burk plots gave straight lines for both aldrin (HHDN) and the dieldrin analogue HCE.
These results give evidence of cytochrome P-450 forms which can metabolize organochlorine compounds at low substrate concentrations.
1(0,0,0,1) Details