| Name | cholinesterase |
|---|---|
| Synonyms | Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase… |
| Name | phosphamidon |
|---|---|
| CAS | 2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl phosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3188364 | Awal MA, Malik JK, Sandhu HS: Measurement by spectrophotometer of blood cholinesterases inactivation following single oral doses of phosphamidon in Bubalus bubalis. Vet Hum Toxicol. 1988 Oct;30(5):444-6. |
87(1,1,2,2) | Details |
| 5153761 | Rose JA, Voss G: Anticholinesterase activity and enzymatic degradation of phosphamidon and -chlorophosphamidon: a comparative study. Bull Environ Contam Toxicol. 1971 May-Jun;6(3):205-8. |
81(1,1,1,1) | Details |
| 3406954 | Bhatnagar P, Soni I: Evaluation of the teratogenic potential of phosphamidon in mice by gavage. Toxicol Lett. 1988 Aug;42(2):101-7. Phosphamidon, an organophosphate pesticide, is an established cholinesterase inhibitor. |
32(0,1,1,2) | Details |
| 1438028 | Ben-Haim SA, Ben-Ami H, Hayam G, Taitelman U, Edoute Y: Obidoxime augments the positive inotropic effect of phosphamidon on the isolated working rat heart. Pharmacol Toxicol. 1992 Aug;71(2):127-31. The present study was designed to determine modulation of the direct inotropic effect of an anticholinesterase organophosphorus compound, phosphamidon, by the reactivator obidoxime. |
31(0,1,1,1) | Details |
| 4013266 | Midtling JE, Barnett PG, Coye MJ, Velasco AR, Romero P, Clements CL, O'Malley MA, Tobin MW, Rose TG, Monosson IH: Clinical management of field worker organophosphate poisoning. West J Med. 1985 Apr;142(4):514-8. A group of 16 cauliflower workers poisoned by residues of the organophosphate insecticides mevinphos and phosphamidon was followed in weekly clinics with interviews and determinations of plasma and erythrocyte cholinesterase levels. |
8(0,0,1,3) | Details |
| 10442219 | Ghosh C, Medda JN: Ameliorating effects of and atropine in phosphamidon intoxicated chick embryos. Biomed Environ Sci. 1999 Mar;12(1):34-42. Treatment of phosphamidon significantly enhanced the mortality and abnormality rates, decreased the average body weights, and cholinesterase activity in chick embryos. |
6(0,0,1,1) | Details |
| 1438017 | Ben-Haim SA, Ben-Ami H, Hayam G, Taitelman U, Edoute Y: Effect of phosphamidon and obidoxime on the QT-RR relationship of isolated rat heart. Pharmacol Toxicol. 1992 Jun;70(6 Pt 1):402-6. We studied the effects of phosphamidon (an organophosphate compound), obidoxime (a cholinesterase reactivator), and their combination, phosphamidon/obidoxime (PD/OB) on cardiac cycle length (RR), QT interval, and on QT-RR relationship of isolated rat heart. |
6(0,0,1,1) | Details |
| 489075 | Qadri SS, Ahmad M: Duration of phosphamidon-induced changes in cholinesterase activity in different organs of rats. Indian J Exp Biol. 1979 Apr;17(4):423-4. |
6(0,0,1,1) | Details |
| 3827420 | Coye MJ, Barnett PG, Midtling JE, Velasco AR, Romero P, Clements CL, Rose TG: Clinical confirmation of organophosphate poisoning by serial cholinesterase analyses. Arch Intern Med. 1987 Mar;147(3):438-42. |
5(0,0,0,5) | Details |
| 1949011 | Ben-Ami H, Ben-Haim SA, Edoute Y, Hayam G, Taitelman U: Direct effects of phosphamidon on isolated working rat heart electrical and mechanical function. Toxicol Appl Pharmacol. 1991 Sep 15;110(3):429-34. It is a water-soluble cholinesterase inhibitor whose estimated rat LD50 is 9.2 mg/kg, ip. |
1(0,0,0,1) | Details |
| 2593091 | Audegond L, Catez D, Foulhoux P, Fournex R, Le Rumeur C, L'Hotellier M, Stepniewski JP: [Potentiation of deltamethrin toxicity by organophosphorus insecticides] . J Toxicol Clin Exp. 1989 May-Jun;9(3):163-76. Others (methyl-parathion, acephate, phosphamidon, monocrotophos) have no such effects, even if they have a very high intrinsic toxicity. Cholinesterase inhibitors of the group are ineffective. |
1(0,0,0,1) | Details |
| 19949736 | Kang EJ, Seok SJ, Lee KH, Gil HW, Yang JO, Lee EY, Hong SY: Factors for determining survival in acute organophosphate poisoning. Korean J Intern Med. 2009 Dec;24(4):362-7. Epub 2009 Nov 27. However, other organophosphates showed different mortality (16.7% for O-ethyl-O- phenylphosphonothioate, 25% for phenthoate, 37.5% for phosphamidon, 50% for methidathion). We investigated patient survival according to initial parameters, including the initial Acute Physiology and Chronic Health Evaluation (APACHE) II score, serum cholinesterase level, and hemoperfusion and evaluated the mortality according to organophosphate types. |
1(0,0,0,1) | Details |
| 5317024 | Martin MA, Kar PP: Effect of cholinesterase inhibitors and PAM on the release of from isolated guinea pig ileum. Jpn J Pharmacol. 1971 Oct;21(5):563-7. |
1(0,0,0,1) | Details |
| 16324745 | Victoria Barahona M, Sanchez-Fortun S: Protective effect induced by atropine, carbamates, and 2- methoiodide Artemia salina larvae exposed to fonofos and phosphamidon. Ecotoxicol Environ Saf. 2007 Jan;66(1):65-73. Epub 2005 Dec 1. The effects of pretreatment with the nonselective muscarinic antagonist atropine, the two reversible acetylcholinesterease inhibitors physostigmine and pyridostigmine, and the cholinesterase-reactivating oxime 2- methoiodide (2-PAM), as individual and combined pretreatments, on OP-induced lethality in 24 h Artemia were also investigated. |
1(0,0,0,1) | Details |
| 8693683 | Tsatsakis AM, Aguridakis P, Michalodimitrakis MN, Tsakalov AK, Alegakis AK, Koumantakis E, Troulakis G: Experiences with acute organophosphate poisonings in Crete. Vet Hum Toxicol. 1996 Apr;38(2):101-7. Significant fluctuations of the plasma cholinesterase activity were observed during therapy. |
1(0,0,0,1) | Details |