| Name | UGT2B |
|---|---|
| Synonyms | UGT2; UGT2; UGT2B; UGT2B@ |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18981171 | Mackenzie PI, Rogers A, Treloar J, Jorgensen BR, Miners JO, Meech R: Identification of UDP glycosyltransferase 3A1 as a UDP N-acetylglucosaminyltransferase. J Biol Chem. 2008 Dec 26;283(52):36205-10. Epub 2008 Nov 3. In addition to UGT3A1 has activity toward 17alpha-estradiol, 17beta- and the prototypic substrates of the UGT1 and UGT2 forms, and 1-naphthol. |
32(0,1,1,2) | Details |
| 9364930 | Belanger G, Beaulieu M, Levesque E, Hum DW, Belanger A: Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey. DNA Cell Biol. 1997 Oct;16(10):1195-205. Northern blot analysis using a pool of human UGT2B cDNA probes demonstrated the expression of homologous UGT2B transcripts in several tissues including the liver, kidney, breast, testis, and prostate of the cynomolgus monkey (Macacafascicularis). The activity of UGT2B9 was tested with over 60 compounds and was demonstrated to be active on C18, C19, and C21 steroids, bile acids, and several xenobiotics including 1-naphthol, and |
4(0,0,0,4) | Details |
| 19487247 | Kerdpin O, Mackenzie PI, Bowalgaha K, Finel M, Miners JO: Influence of N-terminal domain and residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10. Drug Metab Dispos. 2009 Sep;37(9):1948-55. Epub 2009 Jun 1. An N-terminal domain [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 -34). |
2(0,0,0,2) | Details |
| 8333863 | Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI: cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Biochem Biophys Res Commun. 1993 Jul 15;194(1):496-503. The deduced amino acid sequences of UGTs 2B10 and 2B11 share > 76% sequence similarity with other known human liver UGT2B subfamily isoforms and < 48% sequence similarity with UGT1 family proteins. UGT2B11 expressed in COS-7 cells glucuronidated a number of polyhydroxylated estrogens 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (4-methylumbelliferone, 1-naphthol, 2- 4-hydroxybiphenyl and |
1(0,0,0,1) | Details |
| 17686537 | Leaver MJ, Wright J, Hodgson P, Boukouvala E, George SG: Piscine UDP-glucuronosyltransferase 1B. Aquat Toxicol. 2007 Oct 15;84(3):356-65. Epub 2007 Jul 1. The deduced amino acid sequences share greater similarity with mammalian UGT1 family genes than UGT2 genes (44-47% and 39-40% amino acid identity, respectively) and have been designated UGT1B. Expression of a cDNA for plaice UGT1B in cos7 cells resulted in higher 1-naphthol conjugation in cell homogenates compared to steroid conjugation, whilst and bile acid conjugation were undetectable. |
2(0,0,0,2) | Details |
| 10102998 | Belanger G, Barbier O, Hum DW, Belanger A: Molecular cloning, expression and characterization of a monkey steroid UDP-glucuronosyltransferase, UGT2B19, that conjugates Eur J Biochem. 1999 Mar;260(3):701-8. Two cDNA libraries were constructed from monkey liver and prostate mRNA, and a novel UDP-glucuronosyltransferase UGT2B cDNA, UGT2B19, was isolated from both libraries. The enzyme also conjugates xenobiotics including 1-naphthol and |
1(0,0,0,1) | Details |