Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name 1-naphthol
CAS 1-naphthalenol

Reference List

PubMed Abstract RScore(About this table)
2820596 Eastmond DA, French RC, Ross D, Smith MT: Metabolic activation of 1-naphthol and phenol by a simple superoxide-generating system and human leukocytes. Chem Biol Interact. 1987;63(1):47-62.

This formation of 1,4-NQ was dependent upon hypoxanthine, xanthine oxidase, and 1-naphthol and was inhibited by the addition of superoxide dismutase (SOD) demonstrating that the conversion was O2-mediated.
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6210092 Wefers H, Komai T, Sies H: Generation of low-level chemiluminescence during the metabolism of 1-naphthol by rat liver microsomes. Biochem Pharmacol. 1984 Dec 15;33(24):4081-5.

Whereas phase I is hardly influenced by superoxide dismutase, phase II is suppressed.
1(0,0,0,1) Details
6305528 Nakayama T, Kimura T, Kodama M, Nagata C: Generation of hydrogen peroxide and superoxide anion from active metabolites of naphthylamines and aminoazo dyes: its possible role in carcinogenesis. Carcinogenesis. 1983;4(6):765-9.

Autoxidation of active metabolites of naphthylamine and aminoazo dyes in neutral buffer generated hydrogen peroxide (H2O2) and superoxide anion (O-.2), as detected by the titanium sulfate method and nitro blue tetrazolium method, respectively. 2-Amino-1-naphthol, 1-amino-2-naphthol, 1-amino-4-naphthol, N-hydroxy-2-aminonaphthalene, N-hydroxy-1-aminonaphthalene, N-hydroxy-4-aminoazobenzene and N-hydroxy-4-methylaminoazobenzene generated H2O2 and O-.2, whereas 1-nitrosonaphthalene, 2-nitrosonaphthalene, 1-naphtylamine, 2-naphthylamine and non-carcinogenic aminonaphthols and naphthols generated no active oxygens.
Catalase and superoxide dismutase were used to identify the formation of these active oxygens.
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6321045 Thornalley PJ, Doherty MD, Smith MT, Bannister JV, Cohen GM: The formation of active oxygen species following activation of 1-naphthol, 1,2- and 1,4-naphthoquinone by rat liver microsomes. Chem Biol Interact. 1984 Feb;48(2):195-206.

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