| Name | GT1 |
|---|---|
| Synonyms | B4GAL T1; GTB; GT1; UDP Gal; B4GALT1; B4GALT1 protein; Beta4Gal T1; GGTB 2… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3091034 | Finley BL, Ashley PJ, Neptune AG, Yost GS: Substrate-selective induction of rabbit hepatic UDP-glucuronyltransferases by and other xenobiotics. Biochem Pharmacol. 1986 Sep 1;35(17):2875-81. Hepatic microsomes from treated and control animals were incubated with the GT1-type substrates, and 1-naphthol; the GT2-type substrate, morphine; and the steroid substrate, |
81(1,1,1,1) | Details |
| 6807317 | Bock KW, Lilienblum W, Pfeil H: Functional heterogeneity of UDP-glucuronosyltransferase activities in C57BL/6 and DBA/2 mice. Biochem Pharmacol. 1982 Apr 1;31(7):1273-7. Functional heterogeneity of liver microsomal UDP-glucuronosyltransferase activities towards 1-naphthol, 4-methylumbelliferone or 3-hydroxybenzo (a) pyrene (UDP-GT1 activities) and morphine or 4-hydroxybiphenyl (UDP-GT2 activities) was studied in two inbred strains of mice which are genetically responsive (C57BL/6) or non-responsive (DBA/2) to 3-methylcholanthrene-induction of drug metabolizing enzymes. 3-Methylcholanthrene preferentially induced UDP-GT1 activities in C57BL/6 mice. |
33(0,1,1,3) | Details |
| 2139521 | Pandey A, Hassen AM, Benedict DR, Fitzpatrick DW: Effect of UDP-glucuronyltransferase induction on zearalenone metabolism. . Toxicol Lett. 1990 Apr;51(2):203-11. In competitive enzyme assays, the activity of rat liver UDP-GT towards Z was inhibited by 1-naphthol (NA), a GT1 substrate, and 4-hydroxybiphenyl (HB), a GT2 substrate. |
32(0,1,1,2) | Details |
| 3096339 | Koster AS, Schirmer G, Bock KW: Immunochemical and functional characterization of UDP-glucuronosyltransferases from rat liver, intestine and kidney. Biochem Pharmacol. 1986 Nov 15;35(22):3971-5. GT1 activities (1-naphthol, benzo (a) pyrene-3,6- are induced by 3MC in liver microsomes and are present in all tissues investigated. |
8(0,0,1,3) | Details |
| 6179609 | Bock KW, Lilienblum W, Pfeil H, Eriksson LC: Increased -glucuronyltransferase activity in preneoplastic liver nodules and Morris hepatomas. Cancer Res. 1982 Sep;42(9):3747-52. This enzyme form, operationally termed UDP-GT1, accepts 1-naphthol,4-methylumbelliferone, and 3-hydroxybenzo (a) pyrene as substrates and is chiefly inducible in liver by 3-methylcholanthrene-type inducers. |
4(0,0,0,4) | Details |
| 3341022 | Souhaili-el Amri H, Fargetton X, Benoit E, Totis M, Batt AM: Inducing effect of albendazole on rat liver drug-metabolizing enzymes and metabolite pharmacokinetics. Toxicol Appl Pharmacol. 1988 Jan;92(1):141-9. Although a range of derivatives, including benzimidazole itself, were commonly reported as inhibitors of monooxygenase activities, ABZ behaved as an inducer of cytochrome P-448, GT1, and epoxide hydrolase. UDP-glucuronosyltransferase (GT) type 1 activities (1-naphthol, 7-hydroxycoumarin, and 4-methylumbelliferone) were significantly higher than in control microsomes (3- to 4-fold), while GT type 2 activities and -GT remained unchanged. |
1(0,0,0,1) | Details |
| 6805477 | Lilienblum W, Walli AK, Bock KW: Differential induction of rat liver microsomal UDP-glucuronosyltransferase activites by various inducing agents. Biochem Pharmacol. 1982 Mar 15;31(6):907-13. The selectivity of various inducers of UDP-glucuronosyltransferase was investigated in rat liver microsomes and compared with their effect on monooxygenase reactions. (1) Similar to 3-methyl-cholanthrene beta-naphthoflavone selectively stimulated the glucuronidation of 1-naphthol and 4-methylumbelliferone (GT1 substrates). (2) In contrast, DDT preferentially enhanced the glucuronidation of morphine, 4-hydroxybiphenyl (GT2 substrates) and similar to phenobarbital. (3) Colfibric acid and bezafibrate selectively enhanced glucuronidation without affecting GT1 and GT2 reactions. (4) Similar to ethoxyquin and Aroclor 1254, trans-stilbene oxide enhanced both GT1 and GT2 activities but not glucuronidation. (5) In contrast to 3-methylcholanthrene-type inducers which induce both cytochrome P-450MC and GT1, probably through a common receptor protein, ethoxyquin and trans-stilbene oxide markedly induced GT1 reactions without affecting benzo [a] pyrene monooxygenase. |
0(0,0,0,0) | Details |