| Name | UGT1*7 |
|---|---|
| Synonyms | GNT1; UGT 1; UGT1; GNT1; UDPGT; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A 7; UDP glycosyltransferase 1 family polypeptide A7… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15788539 | Di Marco A, D'Antoni M, Attaccalite S, Carotenuto P, Laufer R: Determination of drug glucuronidation and UDP-glucuronosyltransferase selectivity using a 96-well radiometric assay. Drug Metab Dispos. 2005 Jun;33(6):812-9. Epub 2005 Mar 23. The major UGT isoforms identified were UGT1A6, UGT1A7, and UGT1A9 for 4-methylumbelliferone; UGT1A6 and UGT1A8 for 1-naphthol; UGT2B7 for naloxone; UGT1A3 and UGT2B7 for ketoprofen; and UGT1A4 for trifluoperazine. |
6(0,0,1,1) | Details |
| 15502008 | Webb LJ, Miles KK, Auyeung DJ, Kessler FK, Ritter JK: Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8. Drug Metab Dispos. 2005 Jan;33(1):77-82. Epub 2004 Oct 22. Other effective UGT1A8 substrates (> 0.1 nmol/mg/min) included 9-OH-benzo [a] pyrene, 1-naphthol, 4-methylumbelliferone, 7-hydroxycoumarin, chrysin, and |
10(0,0,0,10) | Details |
| 9990312 | Kobayashi T, Yokota H, Ohgiya S, Iwano H, Yuasa A: UDP-glucuronosyltransferase UGT1A7 induced in rat small intestinal mucosa by oral administration of 2-naphthoflavone. Eur J Biochem. 1998 Dec 15;258(3):948-55. In the rat intestine, UDP-glucuronosyltransferase (UGT) isoforms were highly induced by oral administration of 2-naphthoflavone, as shown by intestinal UGT activity toward 1-naphthol (1-NA). |
6(0,0,0,6) | Details |
| 15980103 | Tochigi Y, Yamashiki N, Ohgiya S, Ganaha S, Yokota H: Isoform-specific expression and induction of udp-glucuronosyltransferase in immunoactivated peritoneal macrophages of the rat. Drug Metab Dispos. 2005 Sep;33(9):1391-8. Epub 2005 Jun 24. When macrophage cells cultured in plates were exposed to 1-naphthol and 3-hydroxybenzo-[a] pyrene (3-OH-B [a] P), these glucuronides increased in the medium, indicating that macrophages glucuronidated the chemicals. Northern blot analysis revealed that UGT1A7 mRNA was induced by LPS treatment. |
1(0,0,0,1) | Details |
| 9180348 | Abid A, Sabolovic N, Magdalou J: Expression and inducibility of UDP-glucuronosyltransferases 1-naphthol in human cultured hepatocytes and hepatocarcinoma cell lines. Life Sci. 1997;60(22):1943-51. The UGT isoform present in KYN-2 cells corresponds to UGT1*6, whereas in Mz-Hep-1 cells the UGT isoform present was different from UGT1*6 and UGT1*7. |
1(0,0,0,1) | Details |