| Name | UDP glucuronosyltransferase |
|---|---|
| Synonyms | GNT1; UGT 1; UGT1; GNT1; UDPGT; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A10; UDP glucuronosyltransferase 1 10… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6291111 | Zaleski J, Gessner T: Re-investigation of the presence of UDP-glucuronosyltransferase in rat liver mitochondria. Res Commun Chem Pathol Pharmacol. 1982 Aug;37(2):279-92. In mitochondria the specific activity of UDP-glucuronosyltransferase represented only 7-11% of that found in microsomes, when measured in the presence of various aglycone substrates, including 4-methylumbelliferone, 1-naphthol, phenolphthalein, and 17 |
34(0,1,1,4) | Details |
| 6182644 | Mackenzie PI, Vaisanen M, Hanninen O: Differential induction of UDP glucuronosyltransferase activities towards various substrates after polycyclic aromatic hydrocarbon administration to rats. Toxicol Lett. 1982 Aug;12(4):259-63. Administration of the carcinogens, benzo [a] pyrene and 1,2-benzanthracene, increased UDP glucuronosyltransferase activities towards 3-hydroxybenzo [a] pyrene, 7-hydroxycoumarin and 1-naphthol to a greater extent than did pretreatment with the noncarcinogens, anthracene and phenanthrene. |
8(0,0,1,3) | Details |
| 6442104 | Liu Z, Franklin MR: Separation of four glucuronides in a single sample by high-pressure liquid chromatography and its use in the determination of UDP glucuronosyltransferase activity toward four aglycones. Anal Biochem. 1984 Nov 1;142(2):340-6. A single-solvent, reverse-phase HPLC system that separates glucuronides has been developed, and its applicability to the separation of glucuronides of four substrates (1-naphthol, morphine, and representative of different UDP-glucuronosyltransferase enzymes, has been demonstrated. |
32(0,1,1,2) | Details |
| 20089735 | Itaaho K, Laakkonen L, Finel M: How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?. Drug Metab Dispos. 2010 Apr;38(4):687-96. Epub 2010 Jan 20. On the other hand, studying the kinetics of 1-naphthol glucuronidation yielded more focused results, indicating that residues within segment B (84-147) contribute directly to the K (m) value for this substrate. |
7(0,0,0,7) | Details |
| 7493919 | Yokoi T, Narita M, Nagai E, Hagiwara H, Aburada M, Kamataki T: Inhibition of UDP-glucuronosyltransferase by aglycons of natural glucuronides in kampo medicines using SN-38 as a substrate. Jpn J Cancer Res. 1995 Oct;86(10):985-9. The inhibitory potencies of these aglycons toward -GT were similar to that of 1-naphthol. |
2(0,0,0,2) | Details |
| 18004206 | Udomuksorn W, Elliot DJ, Lewis BC, Mackenzie PI, Yoovathaworn K, Miners JO: Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of and other UDP-glucuronosyltransferase 1A substrates. Pharmacogenet Genomics. 2007 Dec;17(12):1017-29. This work compared the effects of (a) the individual UGT1A1 mutations on the glucuronidation kinetics 4-methylumbelliferone (4MU) and 1-naphthol (1NP), and (b) the Y486 mutation, which occurs in the conserved carboxyl terminal domain of UGT1A enzymes, on 4MU, 1NP and glucuronidation by UGT1A3, UGT1A6 and UGT1A10. |
2(0,0,0,2) | Details |
| 6805477 | Lilienblum W, Walli AK, Bock KW: Differential induction of rat liver microsomal UDP-glucuronosyltransferase activites by various inducing agents. Biochem Pharmacol. 1982 Mar 15;31(6):907-13. The selectivity of various inducers of UDP-glucuronosyltransferase was investigated in rat liver microsomes and compared with their effect on monooxygenase reactions. (1) Similar to 3-methyl-cholanthrene beta-naphthoflavone selectively stimulated the glucuronidation of 1-naphthol and 4-methylumbelliferone (GT1 substrates). (2) In contrast, DDT preferentially enhanced the glucuronidation of morphine, 4-hydroxybiphenyl (GT2 substrates) and similar to phenobarbital. (3) Colfibric acid and bezafibrate selectively enhanced glucuronidation without affecting GT1 and GT2 reactions. (4) Similar to ethoxyquin and Aroclor 1254, trans-stilbene oxide enhanced both GT1 and GT2 activities but not glucuronidation. (5) In contrast to 3-methylcholanthrene-type inducers which induce both cytochrome P-450MC and GT1, probably through a common receptor protein, ethoxyquin and trans-stilbene oxide markedly induced GT1 reactions without affecting benzo [a] pyrene monooxygenase. |
1(0,0,0,1) | Details |
| 15980103 | Tochigi Y, Yamashiki N, Ohgiya S, Ganaha S, Yokota H: Isoform-specific expression and induction of udp-glucuronosyltransferase in immunoactivated peritoneal macrophages of the rat. Drug Metab Dispos. 2005 Sep;33(9):1391-8. Epub 2005 Jun 24. When macrophage cells cultured in plates were exposed to 1-naphthol and 3-hydroxybenzo-[a] pyrene (3-OH-B [a] P), these glucuronides increased in the medium, indicating that macrophages glucuronidated the chemicals. |
1(0,0,0,1) | Details |
| 6800071 | Batt AM, Martin N, Siest G: Induction of group-1 and group-2 UDP-glucuronosyltransferase in microsomes from the livers of C57 Bl/6 mice. Toxicol Lett. 1981 Dec;9(4):355-60. Phenobarbital and 3-methylcholanthrene were much more potent inducers than the other four compounds. 3-methylcholanthrene stimulated the glucuronidation of 4-bromophenol, and 4-chlorophenol ("group-1' substrates) more than phenobarbital, whereas phenobarbital stimulated the glucuronidation of 4-hydroxyphenobarbital, 4-hydroxybiphenyl, morphine, 1-borneol, 4-hydroxyphenytoin, and 1,2,3,4-tetrahydro-1-naphthol ("group-2' substrates). |
1(0,0,0,1) | Details |