| Name | UGT1A8 |
|---|---|
| Synonyms | GNT1; UGT 1; UGT1; GNT1; UDPGT; UDP glucuronosyltransferase; UDP glucuronosyltransferase 1A8; UDP glycosyltransferase 1 family polypeptide A8… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15788539 | Di Marco A, D'Antoni M, Attaccalite S, Carotenuto P, Laufer R: Determination of drug glucuronidation and UDP-glucuronosyltransferase selectivity using a 96-well radiometric assay. Drug Metab Dispos. 2005 Jun;33(6):812-9. Epub 2005 Mar 23. The major UGT isoforms identified were UGT1A6, UGT1A7, and UGT1A9 for 4-methylumbelliferone; UGT1A6 and UGT1A8 for 1-naphthol; UGT2B7 for naloxone; UGT1A3 and UGT2B7 for ketoprofen; and UGT1A4 for trifluoperazine. |
6(0,0,1,1) | Details |
| 15802387 | Luukkanen L, Taskinen J, Kurkela M, Kostiainen R, Hirvonen J, Finel M: Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2005 Jul;33(7):1017-26. Epub 2005 Mar 31. The glucuronidation of entacapone by UGT1A9 was inhibited by 1-naphthol in a competitive fashion, with respect to entacapone, and an uncompetitive fashion, with respect to UDP- (UDPGA). Despite the identical primary structure of the C-terminal halves of the UGT1A isoforms, there were marked differences in the respective K (m) values for UDPGA, ranging from 52 microM for UGT1A6 to 1256 microM for UGT1A8. |
1(0,0,0,1) | Details |
| 15502008 | Webb LJ, Miles KK, Auyeung DJ, Kessler FK, Ritter JK: Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8. Drug Metab Dispos. 2005 Jan;33(1):77-82. Epub 2004 Oct 22. Other effective UGT1A8 substrates (> 0.1 nmol/mg/min) included 9-OH-benzo [a] pyrene, 1-naphthol, 4-methylumbelliferone, 7-hydroxycoumarin, chrysin, and |
88(1,1,1,8) | Details |