| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14738905 | Nebbia C, Dacasto M, Carletti M: Postnatal development of hepatic oxidative, hydrolytic and conjugative drug-metabolizing enzymes in female horses. Life Sci. 2004 Feb 13;74(13):1605-19. Also the carboxylesterases and uridindiphosphoglucuronyl-transferase (UGT) activity toward 1-naphthol displayed a similar trend, glutathione S-transferase accepting 3,4-dichloronitrobenzene as a substrate being the only enzyme activity showing an age-related decline. |
31(0,1,1,1) | Details |
| 2067545 | McMillan JM, Shaddock JG, Casciano DA, Arlotto MP, Leakey JE: Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone. Mutat Res. 1991 Jul;249(1):81-92. DEX treatment also significantly accelerated the decreases in glutathione-S-transferase activities and in sulfotransferase activities towards 1-naphthol and |
7(0,0,1,2) | Details |
| 8345565 | Eltom SE, Babish JG, Schwark WS: The postnatal development of drug-metabolizing enzymes in hepatic, pulmonary and renal tissues of the goat. J Vet Pharmacol Ther. 1993 Jun;16(2):152-63. For phase II enzymes, the activity of UDP-glucuronyltransferase towards 1-naphthol and was measured in addition to the cytosolic glutathione S-transferase activity towards, 1,2-dichloro 3-nitrobenzene. |
6(0,0,1,1) | Details |
| 14508638 | Birkner S, Weber S, Dohle A, Schmahl G, Bolt HM, Follmann W: Activities of drug metabolizing enzymes in bovine colon epithelial cell cultures. Arch Toxicol. 2003 Nov;77(11):621-9. Epub 2003 Sep 24. Whereas activity of amino sulfotransferase (substrate 2-naphthylamine) decreased continuously during the entire culture period, the activity of phenol sulfotransferase (substrate 1-naphthol) decreased only slowly. To examine phase II metabolic potency, activities of N-acetyltransferases 1 and 2, of and amino sulfotransferases, of glutathione S-transferases alpha, mu, pi and theta and of UDP-glucuronyltransferase were measured. |
3(0,0,0,3) | Details |
| 2113070 | Pham MA, Magdalou J, Siest G, Lenoir MC, Bernard BA, Jamoulle JC, Shroot B: Reconstituted epidermis: a novel model for the study of drug metabolism in human epidermis. J Invest Dermatol. 1990 Jun;94(6):749-52. The homogenate fraction contained membrane-bound mixed-function oxydases (cytochrome P-450 dependent) involved in the O-dealkylation of 7-ethoxy-, 7-pentoxy-, and 7-benzoxyresorufin, cytochrome c (P-450) reductase, 5 alpha-reductase, and UDP-glucuronosyltransferases, which conjugate 1-naphthol and One isoform of each glutathione S-transferase, steroid-, and arylsulfatases, acting on - and 4-methylumbelliferone sulfates, was detected. |
1(0,0,0,1) | Details |
| 3358267 | Watkins JB 3rd, Sanders RA, Beck LV: The effect of long-term streptozotocin-induced diabetes on the hepatotoxicity of bromobenzene and carbon tetrachloride and hepatic biotransformation in rats. Toxicol Appl Pharmacol. 1988 Apr;93(2):329-38. Bromobenzene (500 microliters/kg, ip) elicited opposing responses in diabetic and normal rats in N-demethylase activity, in UDP-glucuronosyltransferase activity toward 1-naphthol, and and in glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene. |
6(0,0,1,1) | Details |
| 1936901 | Roques M, Bagrel D, Magdalou J, Siest G: Expression of arylhydrocarbon hydroxylase, epoxide hydrolases, glutathione S-transferase and UDP-glucuronosyltransferases in H5-6 hepatoma cells. Gen Pharmacol. 1991;22(4):677-84. These cells also glucuronidated 1-naphthol efficiently (6 nmol/min per mg) and, at a lower extent, (12 pmol/min per mg). 5. |
3(0,0,0,3) | Details |
| 2125759 | Manning BW, Franklin MR: Induction of rat UDP-glucuronosyltransferase and glutathione S-transferase activities by L-buthionine-S,R-sulfoximine without induction of cytochrome P-450. Toxicology. 1990 Dec 17;65(1-2):149-59. Exposure to 30 mM BSO in drinking water for 7 days induced hepatic microsomal UDP-glucuronosyltransferase activity (detergent-activated) toward (250%), 1-naphthol (210%), morphine (130%) and (140%), but not |
3(0,0,0,3) | Details |
| 2500129 | Pham MA, Magdalou J, Totis M, Fournel-Gigleux S, Siest G, Hammock BD: Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyltransferases in rat skin. Biochem Pharmacol. 1989 Jul 1;38(13):2187-94. Glucuronidation of 1-naphthol, but not of could be followed in the microsomal fraction. Activities of epoxide metabolizing enzymes (microsomal and cytosolic epoxide hydrolases; glutathione S-transferase) were also characterized in skin. |
2(0,0,0,2) | Details |
| 3240719 | Jagadeesan V, Oesch F: Effects of dietary zinc deficiency on the activity of enzymes associated with phase I and II of drug metabolism in Fischer-344 rats: activities of drug metabolising enzymes in zinc deficiency. Drug Nutr Interact. 1988;5(4):403-13. It was observed that the activities of microsomal epoxide hydrolase (with benz (a) pyrene 4-5 oxide as substrate), diphospho glucuronyl transferase (with 1-naphthol as substrate) and cytosolic glutathione-S-transferase (with chlorodinitrobenzene as substrate) were altered exclusively due to zinc deficiency. |
81(1,1,1,1) | Details |
| 10895755 | Chen TL, Wu CH, Chen TG, Tai YT, Chang HC, Lin CJ: Effects of propofol on functional activities of hepatic and extrahepatic conjugation enzyme systems. Br J Anaesth. 2000 Jun;84(6):771-6. The functional activities of phase-II enzymes, including -glucuronosyltransferase (UDPGT), glutathione S-transferase (GST) and N-acetyltransferase (NAT) were evaluated in the presence of various concentrations of propofol (0.05-1.0 mmol litre-1), using 1-naphthol, 1-chloro-2,4-dinitrobenzene and as substrates respectively. |
31(0,1,1,1) | Details |
| 7839362 | Diener B, Abdel-Latif H, Arand M, Oesch F: Xenobiotic metabolizing enzyme activities and viability are well preserved in EDTA-isolated rat liver parenchymal cells after cryopreservation. Toxicol Appl Pharmacol. 1995 Jan;130(1):149-53. The following phase II enzyme activities were also well maintained after cryopreservation: Phenol sulfotransferase (92%), 1-naphthol UDP-glucuronosyl transferase (95%), soluble epoxide hydrolase (87%), and glutathione S-transferase (88%), determined with broad spectrum substrate 1-chloro-2,4-dinitrobenzene. |
31(0,1,1,1) | Details |
| 1410423 | Ghersi-Egea JF, Leininger-Muller B, Minn A, Siest G: Drug metabolizing enzymes in the rat pituitary gland. . Prog Brain Res. 1992;91:373-8. Similarly, microsomal epoxide hydrolase, which inactivates reactive epoxides to trans diol molecules, and two conjugating enzymes, 1-naphthol UDP-glucuronosyltransferase and glutathione-S-transferase, display respectively 6, 4 and 7 times higher activities in the pituitary gland. 7-Benzoxyresorufin-O-dealkylase, 1-naphthol UDP-glucuronosyltransferase and membrane-bound epoxide hydrolase activities were significantly increased in the pituitary gland as an adaptive response to an in vivo treatment by an exogenous inducer, 3-methylcholanthrene. |
31(0,1,1,1) | Details |
| 1567468 | Wortelboer HM, de Kruif CA, van Iersel AA, Falke HE, Noordhoek J, Blaauboer BJ: Acid reaction products of and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes. Biochem Pharmacol. 1992 Apr 1;43(7):1439-47. In rat hepatocytes DIM, CTI and BII enhanced DT-diaphorase (DTD) (= NAD (P) H-quinone reductase) activity, and DIM and BII the glucuronidation of 1-naphthol. |
0(0,0,0,0) | Details |
| 8654197 | Sastry SG, Sanders RA, Veltman JC, Watkins JB 3rd: Minimal effects of two aldose reductase inhibitors, AL-1576 and AL-4114, after subacute topical-ocular dosing on xenobiotic biotransformation in rabbits. Drug Metab Dispos. 1995 Oct;23(10):1094-8. Activities of 1-chloro-2,4-dinitrobenzene glutathione S-transferase, 2-naphthol sulfotransferase, and 1-naphthol UDP-glucuronosyltransferase were not significantly induced in the eight tissues. |
0(0,0,0,0) | Details |
| 8442765 | Ghersi-Egea JF, Perrin R, Leininger-Muller B, Grassiot MC, Jeandel C, Floquet J, Cuny G, Siest G, Minn A: Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain. Biochem Pharmacol. 1993 Feb 9;45(3):647-58. The other drug-metabolizing enzymes catalysing functionalization and conjugation reactions, presented the following characteristics in human brain: (i) a low activity of NADPH-cytochrome P450 reductase, which also catalyses the reduction of some xenobiotics; (ii) a high specific activity of the membrane-bound epoxide hydrolase; (iii) among the enzymes catalysing conjugation reactions, 1-naphthol-UDP-glucuronosyltransferase activity was barely or not detectable, whereas the mean glutathione-S-transferase activity was 15 times higher than the activity measured in rat brain. |
0(0,0,0,0) | Details |
| 8498089 | Franklin MR, Slawson MH, Moody DE: Selective induction of rat liver phase II enzymes by N-heterocycle analogues of phenanthrene: a response exhibiting high correlation between UDP-glucuronosyltransferase and microsomal epoxide hydrolase activities. Xenobiotica. 1993 Mar;23(3):267-77. The detergent-activated UDP-glucuronosyltransferase activities towards morphine, and 1-naphthol were increased up to five-, three- and two-fold of control respectively. Microsomal epoxide hydrolase activity towards cis-stilbene oxide was increased up to three-fold and cytosolic glutathione S-transferase activity towards 1-chloro-2, 4-dinitrobenzene reached twice the control value. 3. |
1(0,0,0,1) | Details |
| 2105094 | Fong AT, Swanson HI, Dashwood RH, Williams DE, Hendricks JD, Bailey GS: Mechanisms of anti-carcinogenesis by Biochem Pharmacol. 1990 Jan 1;39(1):19-26. Dietary I3C had no significant effect on liver microsomal -glucuronyl-transferase activity, measured using the substrates 1-naphthol and or on cytosolic glutathione S-transferase activity, measured using the substrate styrene oxide. |
0(0,0,0,0) | Details |
| 9849642 | Carr BA, Franklin MR: Drug-metabolizing enzyme induction by 2,2'-dipyridyl, 1,7-phenanthroline, 7,8-benzoquinoline and oltipraz in mouse. Xenobiotica. 1998 Oct;28(10):949-56. UDP-glucuronosyltransferase (UGT) activities showed only limited changes, UGT activity towards and 1-naphthol was induced by the 75 mg/kg dose of 2,2'-dipyridyl and UGT activity towards morphine was induced by 150 mg/kg doses of 7,8-benzoquinoline and oltipraz. In contrast with the limited effect on UGT activities, glutathione S-transferase and NAD (P) H:quinone oxidoreductase activities were significantly elevated by most compounds. |
2(0,0,0,2) | Details |
| 16437303 | Gusson F, Carletti M, Albo AG, Dacasto M, Nebbia C: Comparison of hydrolytic and conjugative biotransformation pathways in horse, cattle, pig, broiler chick, rabbit and rat liver subcellullar fractions. Vet Res Commun. 2006 Apr;30(3):271-83. Among food-producing species, the rate of glucuronidation of either 1-naphthol or was in the order pigs approximately rabbits > horses >> cattle > broiler chicks. The activity of cytosolic glutathione S-transferase (GST) accepting the general substrate 1-chloro-2,4-dinitrobenzene was significantly higher in rabbits, horses and pigs than in rat, broiler chicks and cattle. |
1(0,0,0,1) | Details |
| 9134007 | Le HT, Franklin MR: Selective induction of phase II drug metabolizing enzyme activities by quinolines and isoquinolines. Chem Biol Interact. 1997 Mar 14;103(3):167-78. Elevations of UDP-glucuronosyltransferase activities towards 1-naphthol, and morphine elicited by quinoline (1.9- to 2.7-fold), were greater than those elicited by isoquinoline (1.4- to 1.8-fold). Cytosolic glutathione S-transferase (GST) activity was increased similarly (approximately 20%) by both agents. |
1(0,0,0,1) | Details |
| 2243343 | Galinsky RE, Johnson DH, Kane RE, Franklin MR: Effect of aging on hepatic biotransformation in female Fischer 344 rats: changes in sulfotransferase activities are consistent with known gender-related changes in pituitary growth hormone secretion in aging animals. J Pharmacol Exp Ther. 1990 Nov;255(2):577-83. UDP glucuronosyltransferase activity toward 1-naphthol, morphine and was unaffected by advanced age, whereas there was a significant correlation between increased age and increased UDP glucuronosyltransferase activity toward Cytochrome P-450 concentration and glutathione-S-transferase activity toward 1-chloro-2,4-dinitrobenzene were unchanged by aging. |
1(0,0,0,1) | Details |
| 3140501 | Pacifici GM, Franchi M, Bencini C, Repetti F, Di Lascio N, Muraro GB: Tissue distribution of drug-metabolizing enzymes in humans. Xenobiotica. 1988 Jul;18(7):849-56. The activities of the ethoxycoumarin O-deethylase (ECOD), epoxide hydrolase (EH), UDP-glucuronyl transferase (GT), glutathione S-transferase (GST), acetyl transferase (AT) and sulphotransferase (ST) were measured in 6 liver, 8 lung, 8 kidney, 8 intestinal mucosa and 22 urinary bladder mucosa specimens from human subjects. EH and GT were studied with styrene oxide and 1-naphthol, respectively, as substrates, GST, AT and ST were studied with benzo (a) pyrene-4,5-oxide, and 2-naphthol, respectively. 2. |
1(0,0,0,1) | Details |
| 7749597 | Watkins JB 3rd, LaFollette JW, Sanders RA: Biotransformation in Egyptian spiny mouse Acomys cahirinus. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Jan;110(1):101-7. Hepatic glutathione S-transferase activity towards 1-chloro-2,4-dinitrobenzene in females was significantly higher than in males. UDP-Glucuronosyltransferase activity toward 1-naphthol in both sexes in the kidney was significantly higher than hepatic and intestinal activity. |
1(0,0,0,1) | Details |
| 8870952 | Guhe C, Degen GH, Schuhmacher US, Kiefer F, Follmann W: Drug metabolizing enzyme activities in porcine urinary bladder epithelial cell cultures (PUBEC). Arch Toxicol. 1996;70(10):599-606. Glutathione S-transferases activity determined with 1-chloro-2,4-dinitrobenzene decreased gradually to 50% after 1 week and to 20% after 4 weeks in culture compared to fresh cells. A similar decline was also observed for UDP-glucuronyltransferase activities measured with 1-naphthol. |
1(0,0,0,1) | Details |
| 1676957 | Watkins JB 3rd: Effect of microsomal enzyme inducing agents on hepatic biotransformation in cotton rats (Sigmodon hispidus): comparison to that in Sprague-Dawley rats. Comp Biochem Physiol C. 1991;98(2-3):433-9. Benzphetamine N-demethylase and glutathione S-transferases toward 1-chloro-2,4-dinitrobenzene and sulfobromophthalein were higher in male Sigmodon hispidus than the female animals. 2. UDP-Glucuronosyltransferase toward 1-naphthol, diethylstilbestrol and was 2- to 4-fold higher in cotton rats and was not altered by treatment with the inducing agents. 6. |
1(0,0,0,1) | Details |
| 11181502 | Nelson AC, Huang W, Moody DE: Variables in human liver microsome preparation: impact on the kinetics of l-alpha-acetylmethadol (LAAM) n-demethylation and dextromethorphan O-demethylation. Drug Metab Dispos. 2001 Mar;29(3):319-25. Sedimentation plots for the marker enzymes succinate dehydrogenase, NADPH cytochrome P450 reductase (reductase), and glutathione S-transferase in the resulting premicrosomal, microsomal, and cytosolic fractions suggest that enhanced purity of microsomes can be obtained by reducing force of centrifugation, including and increasing the number of homogenization strokes. Each microsomal fraction was also assayed for protein content, cytochrome P450, cytochrome b (5) reductase, cytochrome b (5), absorbance at 420, hydroxylation, hydroxylation, dextromethorphan N- and O-demethylation, glucuronidation of morphine and 1-naphthol, and ester cleavage of p-nitrophenolacetate. |
1(0,0,0,1) | Details |
| 1494890 | Utesch D, Arand M, Thomas H, Petzinger E, Oesch F: Xenobiotic-metabolizing enzyme activities in hybrid cell lines established by fusion of primary rat liver parenchymal cells with hepatoma cells. Xenobiotica. 1992 Dec;22(12):1451-7. Microsomal and cytosolic epoxide hydrolase, glutathione S-transferase and sulphotranserase were low or even below detection limit in FAO. These enzyme activities were significantly higher in HPCT and correspond to about 1-10% the activities measured in PC. 4. 1-Naphthol UPD-glucuronosyl transferase activity was about 20% in FAO and about 100% in HPCT compared to PC. 5. |
1(0,0,0,1) | Details |
| 18725199 | Takahashi S, Sakakibara Y, Mishiro E, Kouriki H, Nobe R, Kurogi K, Yasuda S, Liu MC, Suiko M: Molecular cloning, expression, and characterization of mouse amine N-sulfotransferases. Biochem Biophys Res Commun. 2008 Oct 31;375(4):531-5. Epub 2008 Aug 24. The recombinant form of these two newly identified SULTs, designated SULT3A1 and SULT3A2, were expressed using the pGEX-4T-1 glutathione S-transferase fusion system and purified from transformed BL21 Escherichia coli cells. Kinetic constants of the sulfation of 1-naphthylamine and 1-naphthol by these two enzymes were determined. |
1(0,0,0,1) | Details |
| 2890479 | Watkins JB 3rd, Mangels LA: Hepatic biotransformation in lean and obese Wistar Kyoto rats: comparison to that in streptozotocin-pretreated Sprague-Dawley rats. Comp Biochem Physiol C. 1987;88(1):159-64. UDP-glucuronosyltransferase activity was decreased toward and 1-naphthol in STZ and WKY, and was increased toward in the obese female WKY. 4. Glutathione S-transferase activity was decreased in STZ toward 1-chloro-2,4-dinitrobenzene, ethacrynic acid and sulfobromophthalein, but was similar to that in normal rats for WKY. |
1(0,0,0,1) | Details |
| 3103340 | Trela BA, Carlson GP: Effect of flavanone on mixed-function oxidase and conjugation reactions in rats. Xenobiotica. 1987 Jan;17(1):11-6. Flavanone at 0.05 mmol/kg per day for seven days increased glutathione-S-transferase activity with 1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(p-nitrophenoxy) propane as substrates. Flavanone at 0.05 mmol/kg per day for seven days increased the glucuronidation of 1-naphthol, and at 0.20 mmol/kg increased the glucuronidation of chloramphenicol. |
1(0,0,0,1) | Details |
| 8619256 | Slawson MH, Franklin MR, Moody DE: Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver. Toxicol Lett. 1996 Apr;85(1):29-34. Within the selective induction of phase II enzymes following treatment with dipyridyls or N-heterocyclic analogs of phenanthrene, strong correlations (r > or = 0.70) are observed between the increase of microsomal epoxide hydrolase (mEH) activity and UDP-glucuronosyltransferase (UGT) activities towards 1-naphthol and morphine. Comparisons between the responses of mEH, UGT and glutathione S-transferase (GST) activities were made. mEH activity was increased by beta-naphthoflavone, isosafrole, phenobarbital and clofibric acid. |
1(0,0,0,1) | Details |
| 8363642 | Franklin MR: Induction of rat liver drug-metabolizing enzymes by heterocycle-containing mono-, di-, tri- and tetra-arylmethanes. Biochem Pharmacol. 1993 Aug 17;46(4):683-9. Induction of glutathione S-transferase activity was seen with ten of the compounds and was generally paralleled by changes in overall cytochrome P450 concentration and in both pentoxyresorufin and erythromycin dealkylase activities. UDP-glucuronosyltransferase (1-naphthol) activity was coinduced by these two compounds. |
1(0,0,0,1) | Details |
| 8183245 | Chichester CH, Buckpitt AR, Chang A, Plopper CG: Metabolism and cytotoxicity of naphthalene and its metabolites in isolated murine Clara cells. Mol Pharmacol. 1994 Apr;45(4):664-72. Incubation of cells with 0.5 mM dihydrodiol, 1-naphthol, or 1,2-naphthoquinone decreased cell viability to an extent similar to that produced by 0.5 mM naphthalene. To establish the capability of these cells to metabolize an agent that causes Clara cell-selective toxicity in vivo, we evaluated the metabolism of naphthalene in isolated cells under two distinct conditions, i.e., in homogenized cell preparations supplemented with and glutathione S-transferases and in intact cells. |
1(0,0,0,1) | Details |
| 19142739 | Thibaut R, Schnell S, Porte C: Assessment of metabolic capabilities of PLHC-1 and RTL-W1 fish liver cell lines. Cell Biol Toxicol. 2009 Dec;25(6):611-22. Epub 2009 Jan 15. Metabolic capabilities of PLHC-1 and RTL-W1 cell lines were investigated since to date, cytochrome P450 (CYP) 1A and glutathione-S-transferase have been almost the unique biotransformation enzymes reported in these cells. Functionality of CYP3A-, CYP2M- and CYP2K-like enzymes was assessed by studying the hydroxylation of (T) and (LA), and glucuronidation and sulfation capacity was assessed by looking at 1-naphthol (1-N) and T conjugation. |
1(0,0,0,1) | Details |
| 6506770 | Fujita S, Suzuki M, Suzuki T: Structure-activity relationships in the induction of hepatic drug metabolism by azo compounds. Xenobiotica. 1984 Jul;14(7):565-8. Lipophilic azo compounds possessing 1-phenylazo-2-naphthol or 1-phenylazo-2-naphthylamine moieties induced cytochrome P-448 and related mono-oxygenase activities, -glucuronyltransferase activity towards glutathione-S-transferase activity towards 1-chloro-2,4-dinitrobenzene, aldehyde dehydrogenase, and menadione reductase activities. None of the hydrophilic azo compounds tested and none of the other lipophilic azo compounds tested including 4-phenylazo-1-naphthol induced these activities. |
1(0,0,0,1) | Details |
| 2756713 | Bach J, Snegaroff J: Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: in vivo induction. Xenobiotica. 1989 Jan;19(1):1-9. Glutathione-S-transferase (o-dinitrobenzene as substrate), was unchanged or inhibited by prochloraz. 6. UDP-glucuronosyltransferase (1-naphthol as substrate) was unchanged or inhibited after prochloraz dosing. 5. |
1(0,0,0,1) | Details |
| 3125837 | Yokota H, Hashimoto H, Motoya M, Yuasa A: Enhancement of UDP-glucuronyltransferase, UDP-glucose dehydrogenase, and glutathione S-transferase activities in rat liver by dietary administration of Biochem Pharmacol. 1988 Mar 1;37(5):799-802. The activities of GT of liver microsomes toward various xenobiotic substances such as 1-naphthol, 4-hydroxybiphenyl and 4-methylumbelliferone were enhanced by dietary administration of but the activity of GT toward its endogenous substrate, was not changed. |
1(0,0,0,1) | Details |
| 2903001 | Watkins JB 3rd, Klueber KM: Hepatic phase II biotransformation in C57Bl/KsJ db/db mice: comparison to that in Swiss Webster and 129 REJ mice. Comp Biochem Physiol C. 1988;90(2):417-21. UDP-Glucuronosyltransferase activity toward 1-naphthol, and diethylstilbestrol was not different between db/db and db/+, but was 40% higher in db/db mice toward 3. Glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene and ethacrynic acid was 47 and 59% lower in db/db mice than in male db/+ mice. |
1(0,0,0,1) | Details |
| 9890192 | Carr BA, Franklin MR: Induction of drug metabolizing enzymes by 1,7-phenanthroline and oltipraz in mice is unrelated to Ah-responsiveness. J Biochem Mol Toxicol. 1999;13(2):77-82. Glutathione S-transferases (GST), NAD (P) H: quinone oxidoreductase (QOR), and UDP-glucuronosyltransferases (UGT) play a prominent role in detoxification and can be induced by oltipraz and other N-heterocyclic compounds in rats. In addition to GST and QOR changes, 1,7-phenanthroline significantly elevated UGT (1-naphthol) activity in the Frings strain. |
1(0,0,0,1) | Details |
| 1949033 | Franklin MR: Drug metabolizing enzyme induction by simple diaryl pyridines; 2-substituted isomers selectively increase only conjugation enzyme activities, 4-substituted isomers also induce cytochrome P450. Toxicol Appl Pharmacol. 1991 Oct;111(1):24-32. All five 2-substituted pyridines investigated increased rat hepatic UDP-glucuronosyltransferase activities toward three aglycones (morphine, and 1-naphthol) without inducing cytochrome P450. The two 4-substituted pyridines eliciting induction of cytochrome P450 were also the only 4-isomers which increased cytosolic glutathione-S-transferase activity, but three 2-substituted pyridines (2-benzoylpyridine, 2-benzylpyridine, and trans-1,2-bis (2-pyridyl) ethylene) increased this activity in the absence of cytochrome P450 induction. |
1(0,0,0,1) | Details |
| 8225130 | Kore AM, Jeffery EH, Wallig MA: Effects of 1-isothiocyanato-3-(methylsulfinyl)-propane on xenobiotic metabolizing enzymes in rats. Food Chem Toxicol. 1993 Oct;31(10):723-9. Intestinal glutathione S-transferase (GST) activity and NAD (P) H:quinone reductase (QR) activities were significantly elevated to 3.1 and 8.1 times control values, respectively, at the 100 mumol/kg dose only. The administration of IMSP at 1, 10 or 100 mumol/kg had no significant effect on hepatic Phase I enzymes activities (cytochrome P-450 concentrations, ethoxycoumarin O-deethylase [ECD] and aminopyrine N-demethylase [AND] activities) or Phase II enzyme activities (GST, QR and UDP-glucuronosyltransferase [UDP-GT] activities towards 1-naphthol or 4-hydroxybiphenyl), at any of the doses tested and no effect on intestinal enzyme activities at doses below 100 mumol IMSP/kg. |
1(0,0,0,1) | Details |
| 1358578 | Franklin MR, Moody DE: Concomitant induction of microsomal epoxide hydrolase and UDP-glucuronosyltransferase activities by dipyridine compounds. Drug Metab Dispos. 1992 Sep-Oct;20(5):726-9. There was less correlation (r = 0.60) between epoxide hydrolase activity and both UDP-glucuronosyltransferase activity toward and cytosolic glutathione S-transferase activity. |
1(0,0,0,1) | Details |
| 16906435 | Elovaara E, Mikkola J, Stockmann-Juvala H, Luukkanen L, Keski-Hynnila H, Kostiainen R, Pasanen M, Pelkonen O, Vainio H: Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo (a) pyrene as shown in the rat lung and liver. Arch Toxicol. 2007 Mar;81(3):169-82. Epub 2006 Aug 12. PAH treatment increased the CYP1A-catalyzed activity of pyrene 1-hydroxylation and 7-ethoxyresorufin O-deethylation in rat liver by up to 28- and 279-fold, and in rat lung by up to 22- and 51-fold, respectively. 1-Naphthol (hUGT1A6), 1-hydroxypyrene (hUGT1A6/1A9), and entacapone (hUGT1A9) are markers of PAH-glucuronidating human uridine diphosphate-glucuronosyltransferases (UGT). NADPH:quinone oxidoreductase 1 (NQO1) and glutathione S-transferase activities increased up to 5.3- and 1.6-fold (liver), and up to 4.4- and 1.4-fold (lung), respectively. |
1(0,0,0,1) | Details |
| 9176741 | Le HT, Lamb JG, Franklin MR: Drug metabolizing enzyme induction by benzoquinolines, acridine, and quinacrine; tricyclic aromatic molecules containing a single heterocyclic J Biochem Toxicol. 1996;11(6):297-303. A similar pattern but of lesser magnitude was seen with glutathione S-transferase activity. 3,4-Benzoquinoline was the only agent to significantly increase microsomal epoxide hydrolase activity (2,3-fold). Acridine treatment increased UDP-glucuronosyltransferase activity toward morphine (47%), 1-naphthol (28%), (19%), and (19%). |
1(0,0,0,1) | Details |
| 12524029 | Sivapathasundaram S, Sauer MJ, Ioannides C: Xenobiotic conjugation systems in deer compared with cattle and rat. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):169-73. In contrast, glutathione S-transferase activity in hepatic cytosol, determined with 1-chloro-2,4-dinitrobenzene as substrate, was significantly lower in the cattle and deer. |
1(0,0,0,1) | Details |