| Name | 5 lipoxygenase |
|---|---|
| Synonyms | 5 lipoxygenase; 5 LO; 5LPG; ALOX 5; ALOX5; Arachidonate 5 lipoxygenase; Arachidonate 5 lipoxygenase variant; LOG 5… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8564418 | Engman L, Stern D, Frisell H, Vessman K, Berglund M, Ek B, Andersson CM: Synthesis, antioxidant properties, biological activity and molecular modelling of a series of chalcogen analogues of the 5-lipoxygenase inhibitor DuP 654. Bioorg Med Chem. 1995 Sep;3(9):1255-62. As judged by their ability to inhibit stimulated LTB4 biosynthesis in human neutrophils, compounds 1a-1d all turned out to be highly potent 5-lipoxygenase inhibitors with IC50-values ranging from 0.40 microM for 2-benzyl-1-naphthol (1a) to 0.063 microM for 2-phenyltellurenyl-1-naphthol (1d). |
32(0,1,1,2) | Details |
| 2104936 | Batt DG, Maynard GD, Petraitis JJ, Shaw JE, Galbraith W, Harris RR: 2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity. J Med Chem. 1990 Jan;33(1):360-70. To study the effects of structure on in vitro and in vivo activity, four general features of the molecules were varied: the 2-substituent, the 1- group, substitution on the naphthalene rings, and the 1,2-disubstituted naphthalene unit itself. 2-Benzyl-1-naphthol (5a, DuP 654) shows a very attractive profile of topical antiinflammatory activity and is currently in clinical trials as a topically applied antipsoriatic agent. |
3(0,0,0,3) | Details |
| 2552761 | Harris RR, Batt DG, Galbraith W, Ackerman NR: Topical anti-inflammatory activity of DuP 654, a 2-substituted 1-naphthol. . Agents Actions. 1989 Jun;27(3-4):297-9. DuP 654, a 2-substituted 1-naphthol, is an exceptionally potent inhibitor of 5-lipoxygenase. |
81(1,1,1,1) | Details |
| 8394724 | Arenberger P, Raap A, Armah B, Kemeny L, Ruzicka T: The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) is a 12 (S)- receptor antagonist in the human epidermal cell line SCL-II. Skin Pharmacol. 1993;6(2):148-51. Our results show that DuP 654, in addition to its 5-lipoxygenase inhibitory activity, exhibits 12-HETE receptor antagonist effect, and therefore may be of benefit in skin diseases with elevated 12-HETE levels. |
1(0,0,0,1) | Details |
| 1439183 | Kerr JS, Batt DG, Pinto DJ, Stampfli HF: An evaluation of 2-benzyl-1-naphthol (DuP 654) analogs as systemic anti-inflammatory agents. Res Commun Chem Pathol Pharmacol. 1992 Jul;77(1):77-86. The compound is a potent 5-lipoxygenase inhibitor and exhibits inhibitory activity against lipopolysaccharide-stimulated release of interleukin-1 from human monocytes. |
1(0,0,0,1) | Details |