| Name | soluble epoxide hydrolase |
|---|---|
| Synonyms | CEH; Epoxide hydratase; Cytosolic epoxide hydrolase; EPHX 2; EPHX2; Epoxide hydrolase 2; SEH; Soluble epoxide hydrolase… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7839362 | Diener B, Abdel-Latif H, Arand M, Oesch F: Xenobiotic metabolizing enzyme activities and viability are well preserved in EDTA-isolated rat liver parenchymal cells after cryopreservation. Toxicol Appl Pharmacol. 1995 Jan;130(1):149-53. The following phase II enzyme activities were also well maintained after cryopreservation: Phenol sulfotransferase (92%), 1-naphthol UDP-glucuronosyl transferase (95%), soluble epoxide hydrolase (87%), and glutathione S-transferase (88%), determined with broad spectrum substrate 1-chloro-2,4-dinitrobenzene. |
31(0,1,1,1) | Details |
| 2500129 | Pham MA, Magdalou J, Totis M, Fournel-Gigleux S, Siest G, Hammock BD: Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyltransferases in rat skin. Biochem Pharmacol. 1989 Jul 1;38(13):2187-94. Glucuronidation of 1-naphthol, but not of could be followed in the microsomal fraction. Activities of epoxide metabolizing enzymes (microsomal and cytosolic epoxide hydrolases; glutathione S-transferase) were also characterized in skin. |
2(0,0,0,2) | Details |
| 1494890 | Utesch D, Arand M, Thomas H, Petzinger E, Oesch F: Xenobiotic-metabolizing enzyme activities in hybrid cell lines established by fusion of primary rat liver parenchymal cells with hepatoma cells. Xenobiotica. 1992 Dec;22(12):1451-7. Microsomal and cytosolic epoxide hydrolase, glutathione S-transferase and sulphotranserase were low or even below detection limit in FAO. These enzyme activities were significantly higher in HPCT and correspond to about 1-10% the activities measured in PC. 4. 1-Naphthol UPD-glucuronosyl transferase activity was about 20% in FAO and about 100% in HPCT compared to PC. 5. |
1(0,0,0,1) | Details |
| 1936901 | Roques M, Bagrel D, Magdalou J, Siest G: Expression of arylhydrocarbon hydroxylase, epoxide hydrolases, glutathione S-transferase and UDP-glucuronosyltransferases in H5-6 hepatoma cells. Gen Pharmacol. 1991;22(4):677-84. These cells also glucuronidated 1-naphthol efficiently (6 nmol/min per mg) and, at a lower extent, (12 pmol/min per mg). 5. |
0(0,0,0,0) | Details |
| 2840913 | Magdalou J, Totis M, Boiteux-Antoine AF, Fournel-Gigleux S, Siest G, Schladt L, Oesch F: Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver. Biochem Pharmacol. 1988 Sep 1;37(17):3297-304. The activities towards 4-methylumbelliferone, 1-naphthol, morphine or a monoterpenoid nopol, supported by two different isozymes were significantly increased only with the highest dose; meanwhile glucuronidation was 2-fold enhanced, whatever the dose used. |
0(0,0,0,0) | Details |
| 3240719 | Jagadeesan V, Oesch F: Effects of dietary zinc deficiency on the activity of enzymes associated with phase I and II of drug metabolism in Fischer-344 rats: activities of drug metabolising enzymes in zinc deficiency. Drug Nutr Interact. 1988;5(4):403-13. It was observed that the activities of microsomal epoxide hydrolase (with benz (a) pyrene 4-5 oxide as substrate), diphospho glucuronyl transferase (with 1-naphthol as substrate) and cytosolic glutathione-S-transferase (with chlorodinitrobenzene as substrate) were altered exclusively due to zinc deficiency. |
0(0,0,0,0) | Details |