Protein Information

Name quinone oxidoreductase
Synonyms Quinone oxidoreductase; Crystallin zeta; Zeta crystallin; Crystallin zetas; Quinone oxidoreductases; Zeta crystallins; CRYZ; Zeta crystalline…

Compound Information

Name 1-naphthol
CAS 1-naphthalenol

Reference List

PubMed Abstract RScore(About this table)
1567468 Wortelboer HM, de Kruif CA, van Iersel AA, Falke HE, Noordhoek J, Blaauboer BJ: Acid reaction products of indole-3-carbinol and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes. Biochem Pharmacol. 1992 Apr 1;43(7):1439-47.

In rat hepatocytes DIM, CTI and BII enhanced DT-diaphorase (DTD) (= NAD (P) H-quinone reductase) activity, and DIM and BII the glucuronidation of 1-naphthol.
81(1,1,1,1) Details
9134007 Le HT, Franklin MR: Selective induction of phase II drug metabolizing enzyme activities by quinolines and isoquinolines. Chem Biol Interact. 1997 Mar 14;103(3):167-78.

Elevations of UDP-glucuronosyltransferase activities towards 4-nitrophenol, 1-naphthol, and morphine elicited by quinoline (1.9- to 2.7-fold), were greater than those elicited by isoquinoline (1.4- to 1.8-fold).
NAD (P) H quinone oxidoreductase activity was increased 2-fold by quinoline and isoquinoline.
3(0,0,0,3) Details
9890192 Carr BA, Franklin MR: Induction of drug metabolizing enzymes by 1,7-phenanthroline and oltipraz in mice is unrelated to Ah-responsiveness. J Biochem Mol Toxicol. 1999;13(2):77-82.

Glutathione S-transferases (GST), NAD (P) H: quinone oxidoreductase (QOR), and UDP-glucuronosyltransferases (UGT) play a prominent role in detoxification and can be induced by oltipraz and other N-heterocyclic compounds in rats.
In addition to GST and QOR changes, 1,7-phenanthroline significantly elevated UGT (1-naphthol) activity in the Frings strain.
1(0,0,0,1) Details
9176741 Le HT, Lamb JG, Franklin MR: Drug metabolizing enzyme induction by benzoquinolines, acridine, and quinacrine; tricyclic aromatic molecules containing a single heterocyclic nitrogen. J Biochem Toxicol. 1996;11(6):297-303.


Acridine treatment increased UDP-glucuronosyltransferase activity toward morphine (47%), 1-naphthol (28%), testosterone (19%), and estrone (19%).
0(0,0,0,0) Details