| Name | UGT1A3 |
|---|---|
| Synonyms | GNT1; UGT 1; UGT1; GNT1; UDPGT; UDP glycosyltransferase 1 family polypeptide A3; UDP glucuronosyltransferase 1 3; UDP glucuronosyltransferase 1 3 precursor… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17636046 | Kubota T, Lewis BC, Elliot DJ, Mackenzie PI, Miners JO: Critical roles of residues 36 and 40 in the and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4. Mol Pharmacol. 2007 Oct;72(4):1054-62. Epub 2007 Jul 17. UGT1A3 glucuronidates the planar phenols 1-naphthol (1-NP) and 4-methylumbelliferone (4-MU), whereas UGT1A4 converts the tertiary amines (LTG) and trifluoperazine (TFP) to quaternary ammonium glucuronides. |
88(1,1,1,8) | Details |
| 15788539 | Di Marco A, D'Antoni M, Attaccalite S, Carotenuto P, Laufer R: Determination of drug glucuronidation and UDP-glucuronosyltransferase selectivity using a 96-well radiometric assay. Drug Metab Dispos. 2005 Jun;33(6):812-9. Epub 2005 Mar 23. The major UGT isoforms identified were UGT1A6, UGT1A7, and UGT1A9 for 4-methylumbelliferone; UGT1A6 and UGT1A8 for 1-naphthol; UGT2B7 for naloxone; UGT1A3 and UGT2B7 for ketoprofen; and UGT1A4 for trifluoperazine. |
6(0,0,1,1) | Details |
| 10901286 | Sabolovic N, Magdalou J, Netter P, Abid A: Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7. Life Sci. 2000;67(2):185-96. Glucuronidation of phenols (1-naphthol, 4-methylumbelliferone) and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ketoprofen, and carprofen was investigated in human colon carcinoma Caco-2 cell clones. RT-PCR experiments indicated that the PD-7 and TC-7 clones expressed the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A3 and UGT2B7, which could account for the glucuronidation of phenols and carboxylic acids observed. |
2(0,0,0,2) | Details |
| 18004206 | Udomuksorn W, Elliot DJ, Lewis BC, Mackenzie PI, Yoovathaworn K, Miners JO: Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of and other UDP-glucuronosyltransferase 1A substrates. Pharmacogenet Genomics. 2007 Dec;17(12):1017-29. This work compared the effects of (a) the individual UGT1A1 mutations on the glucuronidation kinetics 4-methylumbelliferone (4MU) and 1-naphthol (1NP), and (b) the Y486 mutation, which occurs in the conserved carboxyl terminal domain of UGT1A enzymes, on 4MU, 1NP and glucuronidation by UGT1A3, UGT1A6 and UGT1A10. |
2(0,0,0,2) | Details |