Protein Information

Name apolipoprotein E
Synonyms AD2; APOE; Apo E; Apolipoprotein E; Apolipoprotein E precursor; apoprotein; Apo Es; Apolipoprotein Es…

Compound Information

Name 1-naphthol
CAS 1-naphthalenol

Reference List

PubMed Abstract RScore(About this table)
2382259 Eto M, Watanabe K, Moriyama T, Makino I: Apolipoprotein E phenotyping from plasma by isoelectric focusing and immunoblotting. Tohoku J Exp Med. 1990 Apr;160(4):301-9.

Immunostaining was performed using goat-anti-human apo E as first antibody and biotinylated anti-goat IgG as second antibody, and 4-chlorodel-1-naphthol as a substrate.
36(0,1,1,6) Details
11311212 Schaaf GJ, de Groene EM, Maas RF, Commandeur JN, Fink-Gremmels J: Characterization of biotransformation enzyme activities in primary rat proximal tubular cells. Chem Biol Interact. 2001 Apr 16;134(2):167-90.

In addition, expression of CYP450 apoprotein, including CYP1A, CYP2C, CYP2D, CYP2E and CYP4A, was detected in microsomes from freshly isolated PT cells by immunoblotting using specific antibodies.
Activity of the phase II biotransformation enzymes GST, GGT, beta-lyase and UGT was determined with 1-chloro-2,4-dinitrobenzene, L-glutamic acid gamma-(7-amido-4-methyl-coumarin), S-(1,1,2,2-tetrafluoroethyl)-L-cysteine and 1-naphthol, respectively, as marker substrates.
1(0,0,0,1) Details
8905573 Monshouwer M, Witkamp RF, Nijmeijer SM, Van Leengoed LA, Vernooy HC, Verheijden JH, Van Miert AS: A lipopolysaccharide-induced acute phase response in the pig is associated with a decrease in hepatic cytochrome P450-mediated drug metabolism. J Vet Pharmacol Ther. 1996 Oct;19(5):382-88.

The decrease in cytochrome P450 activities was accompanied by losses of cytochrome P4501A and P4503A apoproteins.
The microsomal glucuronidation rate of 1-naphthol was not affected in LPS-treated pigs.
1(0,0,0,1) Details