| Name | Tyrosinase |
|---|---|
| Synonyms | LB24 AB; Monophenol monooxygenase; OCA1A; OCAIA; SK29 AB; TYR; TYR protein; Tumor rejection antigen AB… |
| Name | 1-naphthol |
|---|---|
| CAS | 1-naphthalenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3929786 | Doherty M D, Cohen GM, Gant TW, Naish S, Riley PA: Metabolism of 1-naphthol by tyrosinase. . Biochem Pharmacol. 1985 Sep 1;34(17):3167-72. 1-Naphthol was metabolized by the polyphenol oxidase, tyrosinase, primarily to 1,2-naphthoquinone and to small amounts of 1,4-naphthoquinone as well as to covalently bound products. |
336(3,6,6,6) | Details |
| 17224140 | Saeed M, Higginbotham S, Rogan E, Cavalieri E: Formation of depurinating N3adenine and N7guanine adducts after reaction of 1,2-naphthoquinone or enzyme-activated 1,2-dihydroxynaphthalene with DNA. Chem Biol Interact. 2007 Feb 20;165(3):175-88. Epub 2006 Dec 16. Similarly, when 1,2-DHN was activated by tyrosinase in the presence of DNA, higher amounts of the N3Ade and N7Gua adducts were detected. This unstable intermediate can lead to formation of 1-naphthol and naphthalene-1,2-dihydrodiol. |
1(0,0,0,1) | Details |