| 17998297 |
Fujiwara R, Nakajima M, Yamanaka H, Katoh M, Yokoi T: Product inhibition of UDP-glucuronosyltransferase (UGT) enzymes by UDP obfuscates the inhibitory effects of UGT substrates. Drug Metab Dispos. 2008 Feb;36(2):361-7. Epub 2007 Nov 12.
Among them, 4 compounds (1-naphthol, 2-naphthol, 4-nitrophenol, and 4-methylumbelliferone) with high turnover rates (V (max)/K (m) value > 200 mul/min/mg) showed more potent inhibition of the activity in human liver microsomes compared with that by the recombinant UGT1A1. |
31(0,1,1,1) |
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