| Name | ACCB |
|---|---|
| Synonyms | ACACB; Biotin carboxylase; ACC beta; ACC2; ACCB; ACCbeta; Acetyl CoA carboxylase 2; Acetyl CoA carboxylase 2 variant… |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19694967 | Schreurs M, Kuipers F, van der Leij FR: Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome. Obes Rev. 2009 Aug 20. Evidence indicates that ACC2, the isoform located in close proximity to CPT1, is the major regulator of CPT1 activity. |
3(0,0,0,3) | Details |
| 18247344 | Lee CK, Cheong HK, Ryu KS, Lee JI, Lee W, Jeon YH, Cheong C: Biotinoyl domain of human carboxylase: Structural insights into the carboxyl transfer mechanism. Proteins. 2008 Aug;72(2):613-24. To explore the mechanism of ACC holoenzyme function, we determined the structure of the biotinoyl domain of human ACC2 and analyzed its characteristics and interaction with the ligase, BirA using NMR spectroscopy. |
2(0,0,0,2) | Details |
| 18452391 | Chung CC, Ohwaki K, Schneeweis JE, Stec E, Varnerin JP, Goudreau PN, Chang A, Cassaday J, Yang L, Yamakawa T, Kornienko O, Hodder P, Inglese J, Ferrer M, Strulovici B, Kusunoki J, Tota MR, Takagi T: A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of production. Assay Drug Dev Technol. 2008 Jun;6(3):361-74. Using this detection method for we measured the activity of sequential enzymes in the fatty acid synthesis pathway to develop an ACC2/FAS-coupled assay where ACC2 produces from |
2(0,0,0,2) | Details |
| 19900410 | Cho YS, Lee JI, Shin D, Kim HT, Jung HY, Lee TG, Kang LW, Ahn YJ, Cho HS, Heo YS: Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. Biochem Biophys Res Commun. 2010 Jan 1;391(1):187-92. Epub 2009 Nov 10. |
2(0,0,0,2) | Details |
| 19519866 | Schreurs M, van Dijk TH, Gerding A, Havinga R, Reijngoud DJ, Kuipers F: Soraphen, an inhibitor of the carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet. Diabetes Obes Metab. 2009 Oct;11(10):987-91. Epub 2009 Jun 10. AIM: Inhibition of the carboxylase (ACC) system, consisting of the isozymes ACC1 and ACC2, may be beneficial for treatment of insulin resistance and/or obesity by interfering with de novo lipogenesis and beta-oxidation. |
2(0,0,0,2) | Details |
| 19717488 | Fuentes T, Ara I, Guadalupe-Grau A, Larsen S, Stallknecht B, Olmedillas H, Santana A, Helge JW, Calbet JA, Guerra B: Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance. Exp Physiol. 2010 Jan;95(1):160-71. Epub 2009 Aug 28. In normal-weight subjects, SOCS3 protein expression, and STAT3, AMPKalpha and ACCbeta phosphorylation, were similar in the deltoid and vastus lateralis muscles. |
2(0,0,0,2) | Details |
| 20074529 | Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, Cooney GJ: Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metab. 2010 Jan;11(1):70-6. Activation of AMP-activated protein kinase (AMPK) is thought to convey many of the beneficial effects of exercise via its inhibitory effect on acetyl-CoA carboxylase 2 (ACC2) and promotion of fatty acid oxidation. |
2(0,0,0,2) | Details |
| 19557180 | Phuchareon J, Ohta Y, Woo JM, Eisele DW, Tetsu O: Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2. PLoS One. 2009 Jun 25;4(6):e6040. |
2(0,0,0,2) | Details |
| 18255222 | Janovska A, Hatzinikolas G, Staikopoulos V, McInerney J, Mano M, Wittert GA: AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity. Mol Cell Endocrinol. 2008 Mar 12;284(1-2):1-10. Epub 2008 Jan 3. We determined the action of leptin on AMPKalpha and ACCbeta phosphorylation and lipid metabolism in soleus (SOL) and extensor digitorum longus (EDL) muscles from lean and obese Wistar rats after 1 and 100 nM leptin. |
2(0,0,0,2) | Details |
| 19236960 | Kaushik VK, Kavana M, Volz JM, Weldon SC, Hanrahan S, Xu J, Caplan SL, Hubbard BK: Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics. Biochim Biophys Acta. 2009 Jun;1794(6):961-7. Epub 2009 Feb 21. |
2(0,0,0,2) | Details |
| 17671740 | Kohjima M, Enjoji M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, Fujino T, Yada M, Yada R, Harada N, Takayanagi R, Nakamuta M: Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med. 2007 Sep;20(3):351-8. The target genes for real-time PCR analysis were as follows: acetyl-CoA carboxylase (ACC) 1, ACC2, fatty acid synthase (FAS), sterol regulatory element-binding protein 1c (SREBP-1c), and adipose differentiation-related protein (ADRP) for evaluation of de novo synthesis and uptake of fatty acids; carnitine palmitoyltransferase 1a; (CPT1a), long-chain acyl-CoA dehydrogenase (LCAD), long-chain L-3-hydroxyacylcoenzyme A dehydrogenase alpha (HADHalpha), uncoupling protein 2 (UCP2), straight-chain acyl-CoA oxidase (ACOX), branched-chain acyl-CoA oxidase (BOX), cytochrome P450 2E1 (CYP2E1), CYP4A11, and peroxisome proliferator-activated receptor (PPAR) alpha for oxidation in the mitochondria, peroxisomes and microsomes; superoxide dismutase (SOD), catalase, and glutathione synthetase (GSS) for antioxidant pathways; and diacylglycerol O-acyltransferase 1 (DGAT1), PPARgamma, and hormone-sensitive lipase (HSL) for triglyceride synthesis and catalysis. |
1(0,0,0,1) | Details |
| 19273578 | Thomson DM, Brown JD, Fillmore N, Ellsworth SK, Jacobs DL, Winder WW, Fick CA, Gordon SE: AMP-activated protein kinase response to contractions and treatment with the AMPK activator in young adult and old skeletal muscle. J Physiol. 2009 May 1;587(Pt 9):2077-86. Epub 2009 Mar 9. The phosphorylations of AMPKalpha and carboxylase (ACC2; a downstream AMPK target) were both greatly increased (P |
1(0,0,0,1) | Details |
| 18485240 | Germani D, Puglianiello A, Cianfarani S: Uteroplacental insufficiency down regulates insulin receptor and affects expression of key enzymes of long-chain fatty acid (LCFA) metabolism in skeletal muscle at birth. Cardiovasc Diabetol. 2008 May 18;7:14. Muscle of the posterior limb was dissected at birth and processed by real-time RT-PCR to analyze the expression of insulin receptor, ACCalpha, ACCbeta (acetyl-CoA carboxylase alpha and beta subunits), ACS (acyl-CoA synthase), AMPK (AMP-activated protein kinase, alpha2 catalytic subunit), CPT1B palmitoyltransferase-1 beta subunit), MCD (malonyl-CoA decarboxylase) in 14 sham and 8 IUGR pups. |
1(0,0,0,1) | Details |
| 17984485 | Jakus PB, Sandor A, Janaky T, Farkas V: Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of accumulation in BAT during reacclimation. J Lipid Res. 2008 Feb;49(2):332-9. Epub 2007 Nov 5. Importantly, in BAT, only the phosphorylation of the ACC1 isoenzyme was enhanced, whereas that of ACC2 remained unchanged. |
1(0,0,0,1) | Details |
| 20036965 | Wang C, Rajput S, Watabe K, Liao DF, Cao D: carboxylase-a as a novel target for cancer therapy. Front Biosci (Schol Ed). 2010 Jan 1;2:515-26. ACC-alpha (ACCA, also termed ACC1) and ACC-beta (ACCB, also designated ACC2). |
1(0,0,0,1) | Details |
| 19251398 | Milanski M, Souza KL, Reis SR, Feres NH, de Souza LM, Arantes VC, Carneiro EM, Boschero AC, Reis MA, Latorraca MQ: Soybean diet modulates carboxylase expression in livers of rats recovering from early-life malnutrition. Nutrition. 2009 Jul-Aug;25(7-8):774-81. Epub 2009 Feb 28. CONCLUSION: Thus, the soybean diet reduced the liver lipid concentration through downregulation of the ACC gene and protein expressions rather than by phosphorylation status, which possibly resulted in decreased lipogenesis and increased beta-oxidation. Hepatic acetyl-coenzyme A carboxylase (ACC)-alpha and ACCbeta mRNA expression was markedly lower in the LS and CS rats than in the LC and CC rats. |
1(0,0,0,1) | Details |
| 19842072 | Peng Y, Lei T, Yuan J, Chen X, Long Q, Zhan J, Lei P, Feng B, Yang Z: induces acetyl-CoA carboxylase 1 expression via activation of CREB1. Endocrine. 2009 Oct 20. In animals, there are two major isoforms of ACCs, ACC1 and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution. |
1(0,0,0,1) | Details |
| 19609084 | Yamazaki T, Tanimoto M, Gohda T, Ohara I, Hagiwara S, Murakoshi M, Matsumoto M, Kaneko S, Aoki T, Toyoda H, Ishikawa Y, Funabiki K, Horikoshi S, Tomino Y: Combination effects of enalapril and losartan on lipid peroxidation in the kidneys of KK-Ay/Ta mice. Nephron Exp Nephrol. 2009;113(2):e66-76. Epub 2009 Jul 16. Expressions of adiponectin, phospho-AMPKalpha (p-AMPKalpha) and phospho-acetyl CoA carboxylase (beta) (p-ACC (beta)) in the kidneys were evaluated by Western blot analyses. |
1(0,0,0,1) | Details |
| 18829285 | Perez-Echarri N, Perez-Matute P, Marcos-Gomez B, Marti A, Martinez JA, Moreno-Aliaga MJ: Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats. J Nutr Biochem. 2009 Sep;20(9):705-14. Epub 2008 Sep 30. EPA administration induced a significant down-regulation in some lipogenic genes such as muscle acetyl CoA carboxylase beta (ACC beta) (P <.05) and liver fatty acid synthase (FAS) (P <.05). |
1(0,0,0,1) | Details |
| 17449569 | Shin ES, Lee HH, Cho SY, Park HW, Lee SJ, Lee TR: downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells. J Nutr. 2007 May;137(5):1127-31. SREBP-1 is also a transcription factor for lipogenic genes, such as desaturase1 (SCD1), acyltransferase (GPAT), and acetyl-CoA carboxylase (ACC) 1, and ACC2. |
1(0,0,0,1) | Details |
| 18221116 | Corbett JW, Harwood JH Jr: Inhibitors of mammalian carboxylase. Recent Pat Cardiovasc Drug Discov. 2007 Nov;2(3):162-80. Studies in ACC2 knockout mice and in experimental animals treated with isozyme-specific antisense oligonucleotides or with isozyme-nonselective ACC inhibitors have demonstrated the potential for treating metabolic syndrome through this modality. |
1(0,0,0,1) | Details |
| 18842111 | Ouadda AB, Levy E, Ziv E, Lalonde G, Sane AT, Delvin E, Elchebly M: Increased hepatic lipogenesis in insulin resistance and Type 2 diabetes is associated with AMPK signalling pathway up-regulation in Psammomys obesus. Biosci Rep. 2009 Jun 15;29(5):283-92. Our investigation provided evidence that the development of insulin resistance/diabetic state in P. obesus is accompanied by (i) body weight gain and hyperlipidaemia; (ii) elevations of hepatic ACC-Ser79 phosphorylation and ACC protein levels; (iii) a rise in the gene expression of cytosolic ACC1 concomitant with invariable mitochondrial ACC2; (iv) an increase in hepatic AMPKalpha-Thr172 phosphorylation and protein expression without any modification in the calculated ratio of phospho-AMPKalpha to total AMPKalpha; (v) a stimulation in ACC activity despite increased AMPKalpha phosphorylation and protein expression; and (vi) a trend of increase in mRNA levels of key lipogenic enzymes [SCD-1 (stearoyl- desaturase-1), mGPAT (mitochondrial isoform of acyltransferase) and FAS (FA synthase)] and transcription factors [SREBP-1 (sterol-regulatory-element-binding protein-1) and ChREBP (carbohydrate responsive element-binding protein)]. |
1(0,0,0,1) | Details |
| 20057367 | Anavi S, Ilan E, Tirosh O, Madar Z: Infusion of a Lipid Emulsion Modulates AMPK and Related Proteins in Rat Liver, Muscle, and Adipose Tissues. Obesity (Silver Spring). 2010 Jan 7. Muscle ACCbeta, and adiponectin receptor 1 (AdipoR1) mRNA levels and PPARgamma-co-activator 1alpha (PGC1alpha) protein levels were also increased in LE-treated rats. |
1(0,0,0,1) | Details |
| 19552511 | Corbett JW: Review of recent carboxylase inhibitor patents: mid-2007-2008. Expert Opin Ther Pat. 2009 Jul;19(7):943-56. Furthermore, published patents claim the discovery of ACC2 isoform selective and ACC1/2 non-selective inhibitors. |
1(0,0,0,1) | Details |
| 19190759 | Castle JC, Hara Y, Raymond CK, Garrett-Engele P, Ohwaki K, Kan Z, Kusunoki J, Johnson JM: ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected]. PLoS One. 2009;4(2):e4369. Epub 2009 Feb 3. |
7(0,0,0,7) | Details |
| 20139635 | Zhao LF, Iwasaki Y, Zhe W, Nishiyama M, Taguchi T, Tsugita M, Kambayashi M, Hashimoto K, Terada Y: Hormonal Regulation of Carboxylase Isoenzyme Gene Transcription. Endocr J. 2010 Feb 7. carboxylase (ACC), consisting of two isoenzymes ACC1 and ACC2, mediates the conversion from to and thus plays a key role for the regulation of lipogenesis. |
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| 18025247 | Waring JF, Yang Y, Healan-Greenberg CH, Adler AL, Dickinson R, McNally T, Wang X, Weitzberg M, Xu X, Lisowski A, Warder SE, Gu YG, Zinker BA, Blomme EA, Camp HS: Gene expression analysis in rats treated with experimental carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J Pharmacol Exp Ther. 2008 Feb;324(2):507-16. Epub 2007 Nov 19. Acetyl CoA carboxylase (ACC) 2, which catalyzes the carboxylation of to form has been identified as a potential target for type 2 diabetes and obesity. |
5(0,0,0,5) | Details |
| 18845612 | Dzamko N, Schertzer JD, Ryall JG, Steel R, Macaulay SL, Wee S, Chen ZP, Michell BJ, Oakhill JS, Watt MJ, Jorgensen SB, Lynch GS, Kemp BE, Steinberg GR: AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. . J Physiol. 2008 Dec 1;586(Pt 23):5819-31. Epub 2008 Oct 9. The activation of AMP-activated protein kinase (AMPK) and phosphorylation/inhibition of acetyl-CoA carboxylase 2 (ACC2) is believed to be the principal pathway regulating fatty acid oxidation. |
4(0,0,0,4) | Details |
| 19390150 | Madauss KP, Burkhart WA, Consler TG, Cowan DJ, Gottschalk WK, Miller AB, Short SA, Tran TB, Williams SP: The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):449-61. Epub 2009 Apr 18. |
4(0,0,0,4) | Details |
| 19618481 | Kreuz S, Schoelch C, Thomas L, Rist W, Rippmann JF, Neubauer H: carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes. Diabetes Metab Res Rev. 2009 Sep;25(6):577-86. METHODS: ACC1 and ACC2 transcript levels were measured by quantitative real-time polymerase chain reaction in metabolically relevant tissues of Zucker fatty, Zucker diabetic fatty and Zucker lean control animals. |
4(0,0,0,4) | Details |
| 17477831 | Liu Y, Zalameda L, Kim KW, Wang M, McCarter JD: Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based assay and a fluorescence polarization-based ADP Assay for high-throughput screening. Assay Drug Dev Technol. 2007 Apr;5(2):225-35. |
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| 17923673 | Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI: Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. Epub 2007 Oct 8. |
3(0,0,0,3) | Details |