Protein Information

Name Ghrelin
Synonyms Appetite regulating hormone; Appetite regulating hormone precursor; GHRL; Ghrelin; Growth hormone releasing peptide; Growth hormone secretagogue; M46 protein; MTLRP…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
18068666 Kohno D, Sone H, Minokoshi Y, Yada T: Ghrelin raises [Ca2+] i via AMPK in hypothalamic arcuate nucleus NPY neurons. Biochem Biophys Res Commun. 2008 Feb 8;366(2):388-92. Epub 2007 Dec 7.

8(0,0,0,8) Details
17505835 Aprahamian CJ, Tekant G, Chen M, Yagmurlu A, Yang YK, Loux T, Harmon CM: A rat model of childhood diet-induced obesity: Roux-en-Y gastric bypass induced changes in metabolic parameters and gastric peptide ghrelin. Pediatr Surg Int. 2007 Jul;23(7):653-7. Epub 2007 May 16.

5(0,0,0,5) Details
18460326 Sleeman MW, Latres E: The CAMplexities of central ghrelin. . Cell Metab. 2008 May;7(5):361-2.

In this issue of Cell Metabolism, Anderson et al. (2008) show that CaMKK2 mediates this effect by forming a unique complex of AMPKalpha/beta with acetyl-CoA carboxylase (ACC) in a pathway distinct from the more established AMP/LKB1 pathway.
2(0,0,0,2) Details
18706411 Li LF, Lu YY, Xiong W, Liu JY, Chen Q: Effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal transit in mice. Eur J Pharmacol. 2008 Oct 24;595(1-3):90-4. Epub 2008 Jul 31.


Administration (i.c.v.) of 5-(tetradecyloxy)-2-furoic acid (TOFA, an acetyl-CoA carboxylase (ACC) inhibitor) or ghrelin attenuated the delayed gastrointestinal mobility effect induced by 10 microg C75.
2(0,0,0,2) Details