Protein Information

Name p38
Synonyms AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
20106991 Little JP, Safdar A, Cermak N, Tarnopolsky MA, Gibala MJ: Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R912-7. Epub 2010 Jan 27.


Recent evidence has linked p38 MAPK and AMPK with activation of PGC-1alpha.
4(0,0,0,4) Details
19914257 Ceylan-Isik AF, Zhao P, Zhang B, Xiao X, Su G, Ren J: Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis. J Mol Cell Cardiol. 2010 Feb;48(2):367-78. Epub 2009 Nov 13.


Oxidative stress, activation of mitogen-activated protein kinase pathways (ERK, JNK and p38), ER stress, autophagy and inflammatory markers iNOS and TNFalpha were evaluated.
2(0,0,0,2) Details
18715874 Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Chu WM, Guan KL, Wan Y: AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J Biol Chem. 2008 Oct 24;283(43):28897-908. Epub 2008 Aug 20.


Using compound C, a specific inhibitor of AMPK and AMPK-specific small interfering RNA knockdown as well as AMPK activator, we found that AMPK serves as a positive regulator for p38 and p53 (Ser (15)) phosphorylation induced by UV radiation and H (2) O (2) treatment.
2(0,0,0,2) Details
18053155 Toyoda H, Zhao MG, Xu H, Wu LJ, Ren M, Zhuo M: Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex. Mol Pain. 2007 Dec 1;3:36.


Inhibitors of c-Jun N-terminal kinase (JNK) and p38, other members of MAPK family, SP600125 and SB203850, suppressed the induction of cingulate LTP generated by the pairing protocol.
1(0,0,0,1) Details