Protein Information

Name beta catenin
Synonyms Beta catenin; CTNNB; CTNNB 1; CTNNB1; Catenin beta; Catenin beta 1; OK/SW cl.35; PRO2286…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19659475 Ferrazzo KL, Neto MM, dos Santos E, dos Santos Pinto D, de Sousa SO: Differential expression of galectin-3, beta-catenin, and cyclin D1 in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. J Oral Pathol Med. 2009 Oct;38(9):701-7. Epub 2009 Jul 31.

4(0,0,0,4) Details
19879857 Hong B, Lui VW, Hui EP, Lu Y, Leung HS, Wong EY, Cheng SH, Ng MH, Mills GB, Chan AT: Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1. Biochem Pharmacol. 2010 Mar 15;79(6):842-52. Epub 2009 Oct 30.


Our study revealed for the first time that multiple invasion-related signaling proteins (beta-catenin, caveolin, Src and EGFR), as well as several growth-related proteins (AMPKalpha, phospho-acetyl-CoA carboxylase (p-ACC), HER-2 and mTOR), which were previously un-described signaling proteins altered by YC-1, were found to be down-modulated by YC-1 in NPC cells.
1(0,0,0,1) Details
17395972 Libe R, Fratticci A, Bertherat J: Adrenocortical cancer: pathophysiology and clinical management. Endocr Relat Cancer. 2007 Mar;14(1):13-28.


These advances underline the importance of genetic alterations in ACC development and point-out to various chromosomal regions (2, 11p15, 11q, 17p13) and genes (IGF-II, p53, beta-catenin, ACTH receptor).
1(0,0,0,1) Details
19500768 Bertherat J, Bertagna X: Pathogenesis of adrenocortical cancer. . Best Pract Res Clin Endocrinol Metab. 2009 Apr;23(2):261-71.


About a third of ACCs harbours somatic activating mutations of the beta-catenin gene.
1(0,0,0,1) Details
18419788 Tadjine M, Lampron A, Ouadi L, Horvath A, Stratakis CA, Bourdeau I: Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). Clin Endocrinol. 2008 Sep;69(3):367-73. Epub 2008 Apr 14.

9(0,0,0,9) Details
18647815 Gaujoux S, Tissier F, Groussin L, Libe R, Ragazzon B, Launay P, Audebourg A, Dousset B, Bertagna X, Bertherat J: Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors. J Clin Endocrinol Metab. 2008 Oct;93(10):4135-40. Epub 2008 Jul 22.

9(0,0,0,9) Details
17721184 Amary MF, Pauwels P, Meulemans E, Roemen GM, Islam L, Idowu B, Bousdras K, Diss TC, O'Donnell P, Flanagan AM: Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool. Am J Surg Pathol. 2007 Sep;31(9):1299-309.

6(0,0,0,6) Details
19194274 Comper F, Antonello D, Beghelli S, Gobbo S, Montagna L, Pederzoli P, Chilosi M, Scarpa A: Expression pattern of claudins 5 and 7 distinguishes solid-pseudopapillary from pancreatoblastoma, acinar cell and endocrine tumors of the pancreas. Am J Surg Pathol. 2009 May;33(5):768-74.


This has been linked to the displacement of E-cadherin and beta-catenin from their normal membrane location, which prevents adherens junctions to form.
5(0,0,0,5) Details
19863445 Pusantisampan T, Sangkhathat S, Kanngurn S, Kayasut K, Jaruratanasirikul S, Chotsampancharoan T, Kritsaneepaiboon S: Cushing's syndrome in an infant secondary to malignant adrenocortical tumors with somatic mutation of beta-catenin. Pediatr Dev Pathol. 2009 Oct 19.

5(0,0,0,5) Details