Protein Information

Name cyclin D1
Synonyms B cell CLL/lymphoma 1; B cell leukemia 1; BCL 1; BCL 1 oncogene; BCL1; CCND 1; CCND1; Cyclin D1…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19360297 Sequeiros-Santiago G, Garcia-Carracedo D, Fresno MF, Suarez C, Rodrigo JP, Gonzalez MV: Oncogene amplification pattern in adenoid cystic carcinoma of the salivary glands. Oncol Rep. 2009 May;21(5):1215-22.


Oncogenic amplification status of six targets previously described to be involved in human carcinogenesis (ERBB1, KIT, PIK3CA, CCND1, MYC and MDM2) were studied by a PCR-based semiquantitative approach.
7(0,0,0,7) Details
19659475 Ferrazzo KL, Neto MM, dos Santos E, dos Santos Pinto D, de Sousa SO: Differential expression of galectin-3, beta-catenin, and cyclin D1 in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. J Oral Pathol Med. 2009 Oct;38(9):701-7. Epub 2009 Jul 31.

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18481005 Ding L, Zhu S, Xie S, Wu X: Effect of exogenous bFGF on the proliferation of human adenoid cystic carcinoma ACC-2 cells. J Huazhong Univ Sci Technolog Med Sci. 2008 Apr;28(2):227-9. Epub 2008 May 15.


To observe the effects of basic fibroblast growth factor (bFGF) on human adenoid cystic carcinoma ACC-2 cell line proliferation and ERK, cyclin D1/p21 (waf/cip1) signaling pathways, human adenoid cystic carcinoma cells (ACC-2) were cultured and the influence of bFGF of different concentrations on cell proliferation was determined by MTT.
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18605443 Ding L, Zhu SR, Xie SX, Wu XB: [Effects of basic fibroblast growth factor on the proliferation of human salivary adenoid cystic carcinoma cell line ACC-2 and extracellular signal-regulated kinase, Cyclin D1, p2waf/cip1 signaling pathway]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2008 Apr;26(2):118-20.

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18332873 Bernheim A, Toujani S, Saulnier P, Robert T, Casiraghi O, Validire P, Temam S, Menard P, Dessen P, Fouret P: High-resolution array comparative genomic hybridization analysis of human bronchial and salivary adenoid cystic carcinoma. Lab Invest. 2008 May;88(5):464-73. Epub 2008 Mar 10.


Among unique CNAs, gains harbored CCND1, KIT/PDGFRA/KDR, MDM2, and JAK2.
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19874425 Rattan R, Giri S, Hartmann L, Shridhar V: Metformin attenuates ovarian cancer cell growth in an AMP- kinase dispensable manner. J Cell Mol Med. 2009 Oct 29.


Our studies show that metformin treatment (1) significantly inhibited proliferation of diverse chemo-responsive and -resistant ovarian cancer cell lines (A2780, CP70, C200, OV202, OVCAR3, SKVO3ip, PE01 and PE04), (2) caused cell cycle arrest accompanied by decreased cyclin D1 and increased p21 protein expression, (3) activated AMPK in various ovarian cancer cell lines as evident from increased phosphorylation of AMPKalpha and its downstream substrate; ACC (Acetyl Co-carboxylase) and enhanced beta- oxidation of fatty acid, (4) attenuated mTOR-S6RP phosphorylation, inhibited protein translational and lipid biosynthetic pathways, thus implicating metformin as a growth inhibitor of ovarian cancer cells.
1(0,0,0,1) Details
18059225 Seethala RR, Hunt JL, Baloch ZW, Livolsi VA, Leon Barnes E: Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol. 2007 Nov;31(11):1683-94.


Ki-67 and p53 labeling indices were elevated in the high-grade components, though c-kit and cyclin-D1 were not.
1(0,0,0,1) Details
18326020 Vekony H, Raaphorst FM, Otte AP, van Lohuizen M, Leemans CR, van der Waal I, Bloemena E: High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma. J Clin Pathol. 2008 Jun;61(6):744-9. Epub 2008 Mar 6.


METHODS: Expression of the cell cycle proteins p53, cyclin D1, p16 (INK4a), E2F1 and Ki-67, together with the Polycomb group (PcG) proteins BMI-1, MEL-18, EZH2 and EED was investigated immunohistochemically 21 formalin-fixed, paraffin-embedded primary ACCs in relation to tumour characteristics.
1(0,0,0,1) Details