| Name | AMPK |
|---|---|
| Synonyms | 5' AMP activated protein kinase subunit beta 1; AMPK; 5' AMP activated protein kinase beta 1 subunit; AMP activated protein kinase beta subunit; AMP activated protein kinase beta 1 non catalytic subunit; AMPK beta 1 chain; AMPK beta1; AMPKb… |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19723093 | Lee YK, Hwang JT, Lee MS, Kim YM, Park OJ: Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway. Ann N Y Acad Sci. 2009 Aug;1171:484-8. These antitumor potentials were accompanied by the increase in p-AMPK and p-Acc as well as antitumor proteins p53 and p21. |
10(0,0,1,5) | Details |
| 17687000 | Shen QW, Zhu MJ, Tong J, Ren J, Du M: Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by in C2C12 myotubes. Am J Physiol Cell Physiol. 2007 Oct;293(4):C1395-403. Epub 2007 Aug 8. ALA stimulates uptake and increases insulin sensitivity by the activation of AMP-activated protein kinase (AMPK) in skeletal muscle, but the underlying mechanism for AMPK activation is unknown. |
10(0,0,0,10) | Details |
| 19756961 | Ramnanan CJ, McMullen DC, Groom AG, Storey KB: The regulation of AMPK signaling in a natural state of profound metabolic rate depression. Mol Cell Biochem. 2010 Feb;335(1-2):91-105. Epub 2009 Sep 15. |
9(0,0,0,9) | Details |
| 19828836 | Benziane B, Bjornholm M, Lantier L, Viollet B, Zierath JR, Chibalin AV: AMP-activated protein kinase activator A-769662 is an inhibitor of the Na (+)-K (+)-ATPase. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1554-66. Epub 2009 Oct 14. Muscle contraction and metabolic stress are potent activators of AMP-activated protein kinase (AMPK). |
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| 20132432 | Shi T, Fan GQ, Xiao SD: SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells. J Dig Dis. 2010 Feb;11(1):55-62. |
8(0,0,0,8) | Details |
| 18482975 | Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M: SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008 Jul 18;283(29):20015-26. Epub 2008 May 14. Because we have recently defined AMPK activation as a key mechanism for the beneficial effects of polyphenols on hepatic lipid accumulation, hyperlipidemia, and atherosclerosis in type 1 diabetic mice, we hypothesize that polyphenol-activated SIRT1 acts upstream of AMPK signaling and hepatocellular lipid metabolism. |
8(0,0,0,8) | Details |
| 18048025 | Chen J, Downs SM: AMP-activated protein kinase is involved in hormone-induced mouse oocyte meiotic maturation in vitro. Dev Biol. 2008 Jan 1;313(1):47-57. Epub 2007 Sep 29. We have previously shown that AMP-activated protein kinase (AMPK) can induce the resumption of meiosis in mouse oocytes maintained in meiotic arrest in vitro. |
8(0,0,0,8) | Details |
| 17404062 | Kim YM, Hwang JT, Kwak DW, Lee YK, Park OJ: Involvement of AMPK signaling cascade in -induced apoptosis of HT-29 colon cancer cells. Ann N Y Acad Sci. 2007 Jan;1095:496-503. |
8(0,0,0,8) | Details |
| 17488641 | Tanaka T, Masuzaki H, Yasue S, Ebihara K, Shiuchi T, Ishii T, Arai N, Hirata M, Yamamoto H, Hayashi T, Hosoda K, Minokoshi Y, Nakao K: Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet. Cell Metab. 2007 May;5(5):395-402. Skeletal muscle AMP-activated protein kinase (AMPK) is activated by leptin and serves as a master regulator of fatty acid beta-oxidation. |
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| 20139613 | Yuan HD, Yuan HY, Chung SH, Jin GZ, Piao GC: An active part of Artemisia sacrorum Ledeb. attenuates hepatic lipid accumulation through activating AMP-activated protein kinase in human HepG2 cells. Biosci Biotechnol Biochem. 2010 Feb 23;74(2):322-8. Epub 2010 Feb 7. Therefore, we investigated whether 95% eluate (EE), an active part of ASL, would attenuate hepatic lipid accumulation in human HepG2 cells by activating AMP-activated protein kinase (AMPK). |
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| 18379076 | Park MW, Ha J, Chung SH: 20 (S)-ginsenoside Rg3 enhances -stimulated insulin secretion and activates AMPK. Biol Pharm Bull. 2008 Apr;31(4):748-51. |
3(0,0,0,3) | Details |
| 20074529 | Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, Cooney GJ: Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metab. 2010 Jan;11(1):70-6. Activation of AMP-activated protein kinase (AMPK) is thought to convey many of the beneficial effects of exercise via its inhibitory effect on acetyl-CoA carboxylase 2 (ACC2) and promotion of fatty acid oxidation. |
3(0,0,0,3) | Details |
| 19483304 | Zhou Y, Wang D, Zhu Q, Gao X, Yang S, Xu A, Wu D: Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis. Biol Pharm Bull. 2009 Jun;32(6):993-8. AMP-activated protein kinase (AMPK) is a central player in and lipid metabolism while its role in adipocyte differentiation remains obscure. |
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| 17855357 | Goransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K: Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem. 2007 Nov 9;282(45):32549-60. Epub 2007 Sep 12. We have studied the mechanism of A-769662, a new activator of AMP-activated protein kinase (AMPK). |
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| 17884446 | Guo Z, Xia Z, Yuen VG, McNeill JH: Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats. Metabolism. 2007 Oct;56(10):1363-71. Adiponectin can improve both metabolism and insulin resistance via the -activated protein kinase (AMPK) signaling pathway. |
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| 18845612 | Dzamko N, Schertzer JD, Ryall JG, Steel R, Macaulay SL, Wee S, Chen ZP, Michell BJ, Oakhill JS, Watt MJ, Jorgensen SB, Lynch GS, Kemp BE, Steinberg GR: AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. . J Physiol. 2008 Dec 1;586(Pt 23):5819-31. Epub 2008 Oct 9. |
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| 19154959 | Koshinaka K, Kawasaki E, Hokari F, Kawanaka K: Effect of acute high-intensity intermittent swimming on post-exercise insulin responsiveness in epitrochlearis muscle of fed rats. Metabolism. 2009 Feb;58(2):246-53. HIS increased (P < .05) the phosphorylation of -activated protein kinase (AMPK) (172) and that of its downstream target carboxylase (ACC) Ser (79) 12.6- and 3.1-fold, respectively, whereas LIS increased them 3.8- and 1.9-fold, respectively, immediately after exercise compared with rested muscle. |
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| 18842111 | Ouadda AB, Levy E, Ziv E, Lalonde G, Sane AT, Delvin E, Elchebly M: Increased hepatic lipogenesis in insulin resistance and Type 2 diabetes is associated with AMPK signalling pathway up-regulation in Psammomys obesus. Biosci Rep. 2009 Jun 15;29(5):283-92. |
3(0,0,0,3) | Details |
| 18255222 | Janovska A, Hatzinikolas G, Staikopoulos V, McInerney J, Mano M, Wittert GA: AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity. Mol Cell Endocrinol. 2008 Mar 12;284(1-2):1-10. Epub 2008 Jan 3. |
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| 19890358 | Guo HX, Liu DH, Ma Y, Liu JF, Wang Y, Du ZY, Wang X, Shen JK, Peng HL: Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol Sin. 2009 Nov;30(11):1505-12. In the liver, the phosphorylation of AMP activated protein kinase (AMPK) and carboxylase (ACC) and the gene expression of some enzymes involved in lipogenesis were examined. |
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| 20082303 | Jung JH, Lee JO, Kim JH, Lee SK, You GY, Park SH, Park JM, Kim EK, Suh PG, An JK, Kim HS: suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation. J Cell Physiol. 2010 May;223(2):408-14. |
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| 19418221 | Saito M, Chakraborty G, Mao RF, Vadasz C, Saito M: Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brain. Neurochem Res. 2009 Nov;34(11):1945-54. Epub 2009 May 6. Presently, we examined developmental changes in the levels and cellular localization of FAS and ACC, and their putative regulators, sterol-regulatory element-binding protein (SREBP)-1 and AMP-activated protein kinase (AMPK) in the mouse brain. |
3(0,0,0,3) | Details |
| 18614968 | Yatscoff MA, Jaswal JS, Grant MR, Greenwood R, Lukat T, Beker DL, Rebeyka IM, Lopaschuk GD: Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart. Pediatr Res. 2008 Dec;64(6):643-7. Decreased ACC activity corresponds to an increase in the activity of 5'-AMP activated protein kinase (AMPK), which phosphorylates and inhibits ACC. |
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| 19176702 | Cook N, Fraser SA, Katerelos M, Katsis F, Gleich K, Mount PF, Steinberg GR, Levidiotis V, Kemp BE, Power DA: Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells. Am J Physiol Renal Physiol. 2009 Apr;296(4):F801-9. Epub 2009 Jan 28. The energy-sensing kinase AMP-activated protein kinase (AMPK) is associated with the -potassium-chloride cotransporter NKCC2 in the kidney and phosphorylates it on a regulatory site in vitro. |
8(0,0,0,8) | Details |
| 19273578 | Thomson DM, Brown JD, Fillmore N, Ellsworth SK, Jacobs DL, Winder WW, Fick CA, Gordon SE: AMP-activated protein kinase response to contractions and treatment with the AMPK activator in young adult and old skeletal muscle. J Physiol. 2009 May 1;587(Pt 9):2077-86. Epub 2009 Mar 9. |
7(0,0,0,7) | Details |
| 19071085 | Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB: Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun. 2009 Jan 23;378(4):836-41. Epub 2008 Dec 9. We examined in HepG2 cells whether -induced changes in AMP-activated protein kinase (AMPK) activity could be mediated by SIRT1, an NAD (+)-dependent histone/protein deacetylase that has been linked to the increase in longevity caused by caloric restriction. |
5(0,0,0,5) | Details |
| 20221273 | Hao J, Kim HS, Choi W, Ha TS, Ahn HY, Kim CH: Mechanical Stretch-Induced Protection against Myocardial Ischemia-Reperfusion Injury Involves AMP-Activated Protein Kinase. Korean J Physiol Pharmacol. 2010 Feb;14(1):1-9. Epub 2010 Feb 28. AMP-activated protein kinase (AMPK) protects various tissues and cells from ischemic insults and is activated by many stimuli including mechanical stretch. |
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| 17960559 | Fediuc S, Pimenta AS, Gaidhu MP, Ceddia RB: Activation of AMP-activated protein kinase, inhibition of pyruvate dehydrogenase activity, and redistribution of substrate partitioning mediate the acute insulin-sensitizing effects of troglitazone in skeletal muscle cells. J Cell Physiol. 2008 May;215(2):392-400. Exposure of L6 myotubes to troglitazone for 1 h significantly increased phosphorylation of AMPK and ACC, which was followed by approximately 30% and approximately 60% increases in oxidation and palmitoyl transferase-1 (CPT-1) activity, respectively. |
3(0,0,0,3) | Details |
| 18614941 | Lee-Young RS, Koufogiannis G, Canny BJ, McConell GK: Acute exercise does not cause sustained elevations in AMPK signaling or expression. Med Sci Sports Exerc. 2008 Aug;40(8):1490-4. The purpose of this study was to assess AMPK signaling in human skeletal muscle immediately after a single bout of moderate-intensity endurance exercise and 3 and 24 h after the exercise bout. |
3(0,0,0,3) | Details |
| 19052642 | Ropelle ER, Fernandes MF, Flores MB, Ueno M, Rocco S, Marin R, Cintra DE, Velloso LA, Franchini KG, Saad MJ, Carvalheira JB: Central exercise action increases the AMPK and mTOR response to leptin. . PLoS One. 2008;3(12):e3856. Epub 2008 Dec 4. |
7(0,0,0,7) | Details |
| 17684106 | Ratchford AM, Chang AS, Chi MM, Sheridan R, Moley KH: Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1198-206. Epub 2007 Aug 7. Protein levels of phosphorylated AMP-activated protein kinase (AMPK) and carboxylase (ACC) were also measured. |
7(0,0,0,7) | Details |
| 18535107 | Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y: Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via -activated protein kinase signaling in the arcuate nucleus of rats. Endocrinology. 2008 Sep;149(9):4544-53. Epub 2008 Jun 5. Recent studies suggest that the AMP-activated protein kinase (AMPK) signaling in the hypothalamus is the master regulator of energy balance. |
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| 17934342 | Qiang W, Weiqiang K, Qing Z, Pengju Z, Yi L: Aging impairs insulin-stimulated uptake in rat skeletal muscle via suppressing AMPKalpha. Exp Mol Med. 2007 Aug 31;39(4):535-43. AMP-activated protein kinase (AMPK) is an important regulator of intracellular fat oxidation and was evidenced to play a key role in high- and high-fat induced glucose intolerance. |
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| 19182950 | Kim do Y, Yuan HD, Chung IK, Chung SH: Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells. J Agric Food Chem. 2009 Feb 25;57(4):1532-7. |
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| 18434188 | Zhang F, Sun C, Wu J, He C, Ge X, Huang W, Zou Y, Chen X, Qi W, Zhai Q: Combretastatin A-4 activates AMP-activated protein kinase and improves metabolism in db/db mice. Pharmacol Res. 2008 Apr;57(4):318-23. Epub 2008 Mar 15. was reported to increase insulin sensitivity accompanied with the activation of AMP-activated protein kinase (AMPK), which is a key regulator of energy balance and an important drug target for type 2 diabetes. |
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| 17925454 | Thomson DM, Brown JD, Fillmore N, Condon BM, Kim HJ, Barrow JR, Winder WW: LKB1 and the regulation of and fatty acid oxidation in muscle. . Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1572-9. Epub 2007 Oct 9. 5'-AMP-activated protein kinase (AMPK), by way of its inhibition of carboxylase (ACC), plays an important role in regulating levels and the rate of fatty acid oxidation in skeletal and cardiac muscle. |
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| 19158325 | Berggreen C, Gormand A, Omar B, Degerman E, Goransson O: Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E635-46. Epub 2009 Jan 21. The regulation of the rate-limiting lipogenic enzyme carboxylase (ACC) by insulin through dephosphorylation of S79, which is a target for AMP-activated protein kinase (AMPK), was dependent on the presence of active PKB. |
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| 19190259 | Babraj JA, Mustard K, Sutherland C, Towler MC, Chen S, Smith K, Green K, Leese G, Hardie DG, Rennie MJ, Cuthbertson DJ: Blunting of -induced human skeletal muscle uptake in type 2 diabetes is dependent on age rather than diabetic status. Am J Physiol Endocrinol Metab. 2009 May;296(5):E1042-8. Epub 2009 Feb 3. We demonstrated previously that, in healthy young men, 1- stimulates human muscle 2-deoxyglucose (2DG) uptake without detectable activation of muscle AMP-activated protein kinase (AMPK) but with extracellular-regulated kinase 1/2 (ERK1/2) activation. |
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| 17635921 | An Z, Wang H, Song P, Zhang M, Geng X, Zou MH: -induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress. J Biol Chem. 2007 Sep 14;282(37):26793-801. Epub 2007 Jul 16. Recent studies suggest that the AMP-activated protein kinase (AMPK) acts as a major energy sensor and regulator in adipose tissues. |
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| 18715874 | Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Chu WM, Guan KL, Wan Y: AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J Biol Chem. 2008 Oct 24;283(43):28897-908. Epub 2008 Aug 20. AMP-activated protein kinase or AMPK is an evolutionarily conserved sensor of cellular energy status, activated by a variety of cellular stresses that deplete ATP. |
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| 18435912 | Hwang SL, Yang BK, Lee JY, Kim JH, Kim BD, Suh KH, Kim DY, Kim MS, Song H, Park BS, Huh TL: Isodihydrocapsiate stimulates plasma uptake by activation of AMP-activated protein kinase. Biochem Biophys Res Commun. 2008 Jun 27;371(2):289-93. Epub 2008 Apr 22. AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that is implicated as a key factor in controlling whole body homeostasis, including fatty acid oxidation and uptake. |
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| 19826102 | Deshmukh AS, Glund S, Tom RZ, Zierath JR: Role of the AMPKgamma3 isoform in hypoxia-stimulated transport in glycolytic skeletal muscle. Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1388-94. Epub 2009 Oct 13. Skeletal muscle transport is regulated via the canonical insulin-signaling cascade as well as by energy-sensing signals. 5'-AMP-activated protein kinase (AMPK) has been implicated in the energy status regulation of transport. |
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| 19427916 | Proszkowiec-Weglarz M, Richards MP, Humphrey BD, Rosebrough RW, McMurtry JP: AMP-activated protein kinase and carbohydrate response element binding protein: a study of two potential regulatory factors in the hepatic lipogenic program of broiler chickens. Comp Biochem Physiol B Biochem Mol Biol. 2009 Sep;154(1):68-79. Epub 2009 May 8. This study investigated the effects of fasting and refeeding on AMP-activated protein kinase (AMPK) and carbohydrate response element binding protein (ChREBP) mRNA, protein and activity levels; as well as the expression of lipogenic genes involved in regulating lipid synthesis in broiler chicken (Gallus gallus) liver. |
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| 19100718 | Rivera L, Moron R, Zarzuelo A, Galisteo M: Long-term administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol. 2009 Mar 15;77(6):1053-63. Epub 2008 Dec 3. Furthermore, the elevated hepatic lipid content was significantly lower in obese rats treated with an effect which was related to the increased phosphorylation of 5'-AMP-activated protein kinase (AMPK) and carboxylase (ACC) in the liver of these animals. |
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| 18474592 | Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, Zou MH: Reactive species is required for the activation of the AMP-activated protein kinase by in vivo. J Biol Chem. 2008 Jul 18;283(29):20186-97. Epub 2008 May 12. The AMP-activated protein kinase (AMPK) is reported to mediate the beneficial effects of on the vascular functions, but the biochemical mechanisms are incompletely understood. |
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| 18187610 | Thomson DM, Fick CA, Gordon SE: AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions. J Appl Physiol. 2008 Mar;104(3):625-32. Epub 2008 Jan 10. |
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| 20106991 | Little JP, Safdar A, Cermak N, Tarnopolsky MA, Gibala MJ: Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R912-7. Epub 2010 Jan 27. Recent evidence has linked p38 MAPK and AMPK with activation of PGC-1alpha. |
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| 19662644 | Huang CH, Tsai SJ, Wang YJ, Pan MH, Kao JY, Way TD: inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells. Mol Nutr Food Res. 2009 Sep;53(9):1156-65. One key enzyme thought to be activated during CR is AMP-activated kinase (AMPK), a sensor of cellular energy levels. |
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| 19720090 | Zhang HS, Wu MR: SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase. Virus Res. 2009 Dec;146(1-2):51-7. Epub 2009 Aug 29. Western blot analysis showed a significant reduction in AMPK activation and downstream carboxylase (ACC) activation in response to Tat treatment. |
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| 20057367 | Anavi S, Ilan E, Tirosh O, Madar Z: Infusion of a Lipid Emulsion Modulates AMPK and Related Proteins in Rat Liver, Muscle, and Adipose Tissues. Obesity (Silver Spring). 2010 Jan 7. |
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| 20023137 | Zhao JX, Yan X, Tong JF, Means WJ, McCormick RJ, Zhu MJ, Du M: Mouse AMP-activated protein kinase gamma3 subunit R225Q mutation affecting mouse growth performance when fed a high-energy diet. J Anim Sci. 2010 Apr;88(4):1332-40. Epub 2009 Dec 18. The AMPK content and its downstream target, carboxylase (ACC), content were greater in RN mice (P < 0.05). |
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| 19459711 | Way TD, Lin HY, Kuo DH, Tsai SJ, Shieh JC, Wu JC, Lee MR, Lin JK: Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells. J Agric Food Chem. 2009 Jun 24;57(12):5257-64. |
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| 18586010 | Ahn J, Lee H, Kim S, Park J, Ha T: The anti-obesity effect of is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun. 2008 Sep 5;373(4):545-9. Epub 2008 Jun 27. |
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| 17956983 | Gao S, Kinzig KP, Aja S, Scott KA, Keung W, Kelly S, Strynadka K, Chohnan S, Smith WW, Tamashiro KL, Ladenheim EE, Ronnett GV, Tu Y, Birnbaum MJ, Lopaschuk GD, Moran TH: Leptin activates hypothalamic carboxylase to inhibit food intake. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17358-63. Epub 2007 Oct 23. We report that intracerebroventricular (ICV) injection of leptin, concomitant with inhibiting AMP-activated kinase (AMPK), activates carboxylase (ACC), the key regulatory enzyme in fatty acid biosynthesis, in the arcuate nucleus (Arc) and paraventricular nucleus (PVN) in the hypothalamus. |
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| 18358090 | Sun Y, Ren M, Gao GQ, Gong B, Xin W, Guo H, Zhang XJ, Gao L, Zhao JJ: Chronic exposure inhibits AMPKalpha and decreases -stimulated insulin secretion from beta-cells: modulation by fenofibrate. Acta Pharmacol Sin. 2008 Apr;29(4):443-50. AIM: -activated protein kinase (AMPK), a vital regulator of metabolism, may affect insulin secretion in beta-cells. |
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| 19214174 | Anthony NM, Gaidhu MP, Ceddia RB: Regulation of visceral and subcutaneous adipocyte lipolysis by acute -induced AMPK activation. Obesity (Silver Spring). 2009 Jul;17(7):1312-7. Epub 2009 Feb 12. |
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| 19900410 | Cho YS, Lee JI, Shin D, Kim HT, Jung HY, Lee TG, Kang LW, Ahn YJ, Cho HS, Heo YS: Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. Biochem Biophys Res Commun. 2010 Jan 1;391(1):187-92. Epub 2009 Nov 10. |
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| 19498441 | Izumi Y, Shiota M, Kusakabe H, Hikita Y, Nakao T, Nakamura Y, Muro T, Miura K, Yoshiyama M, Iwao H: accelerates ischemia-induced angiogenesis through AMP-activated protein kinase. Hypertens Res. 2009 Aug;32(8):675-9. Epub 2009 Jun 5. An in vitro study on human umbilical vein endothelial cells (HUVECs) revealed that increased the phosphorylation of AMPK. |
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| 18369362 | Suzuki K, Uchida K, Nakanishi N, Hattori Y: Cilostazol activates AMP-activated protein kinase and restores endothelial function in diabetes. Am J Hypertens. 2008 Apr;21(4):451-7. Epub 2008 Feb 7. We investigated whether AMP-activated protein kinase (AMPK) activity is a downstream mediator of the beneficial effects of cilostazol on vascular endothelial cells and whether cilostazol might reverse endothelial dysfunction in diabetic rats. |
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| 17709221 | To K, Yamaza H, Komatsu T, Hayashida T, Hayashi H, Toyama H, Chiba T, Higami Y, Shimokawa I: Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver. Exp Gerontol. 2007 Nov;42(11):1063-71. Epub 2007 Jul 18. AMP-activated protein kinase (AMPK) may act as a key enzyme for metabolic adaptation to calorie restriction (CR) or reduced growth hormone (GH)-insulin-like growth factor (IGF)-1 signaling, an experimental intervention for lifespan extension in animals. |
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| 20102710 | Lee W, Kim MJ, Park EJ, Choi YJ, Park SY: C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase. FEBS Lett. 2010 Mar 5;584(5):968-72. Epub 2010 Jan 26. Here we demonstrate that the globular domain of CTRP6 mediates the phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) in skeletal muscle cells. |
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| 19073152 | Zhao P, Wang J, Ma H, Xiao Y, He L, Tong C, Wang Z, Zheng Q, Dolence EK, Nair S, Ren J, Li J: A newly synthetic complex- (D- 3 activates AMP-activated protein kinase and stimulates transport. Biochem Pharmacol. 2009 Mar 15;77(6):1002-10. Epub 2008 Nov 25. AMP-activated protein kinase (AMPK) is a key mediator for uptake and insulin sensitivity. |
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| 17935292 | Underwood KR, Tong J, Zhu MJ, Shen QW, Means WJ, Ford SP, Paisley SI, Hess BW, Du M: Relationship between kinase phosphorylation, muscle fiber typing, and accumulation in longissimus muscle of beef cattle with high and low intramuscular fat. J Agric Food Chem. 2007 Nov 14;55(23):9698-703. Epub 2007 Oct 13. The objective of this study was to examine the association of (AMP)-activated protein kinase (AMPK) with content in bovine muscle and their links with intramuscular fat (IMF) and muscle fiber type composition. |
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| 19609084 | Yamazaki T, Tanimoto M, Gohda T, Ohara I, Hagiwara S, Murakoshi M, Matsumoto M, Kaneko S, Aoki T, Toyoda H, Ishikawa Y, Funabiki K, Horikoshi S, Tomino Y: Combination effects of enalapril and losartan on lipid peroxidation in the kidneys of KK-Ay/Ta mice. Nephron Exp Nephrol. 2009;113(2):e66-76. Epub 2009 Jul 16. BACKGROUND: activated protein kinase (AMPK) has a protective effect on lipid peroxidation. |
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| 17409402 | Zhou W, Han WF, Landree LE, Thupari JN, Pinn ML, Bililign T, Kim EK, Vadlamudi A, Medghalchi SM, El Meskini R, Ronnett GV, Townsend CA, Kuhajda FP: Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Res. 2007 Apr 1;67(7):2964-71. Inhibition of FAS and activation of AMP-activated protein kinase (AMPK) have been shown to be cytotoxic to human cancer cells in vitro and in vivo. |
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| 18561258 | Pimenta AS, Gaidhu MP, Habib S, So M, Fediuc S, Mirpourian M, Musheev M, Curi R, Ceddia RB: Prolonged exposure to impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells. J Cell Physiol. 2008 Nov;217(2):478-85. The aim of this study was to investigate the chronic effects of on fatty acid (FA) oxidation, AMPK/ACC phosphorylation/activation, intracellular lipid accumulation, and the molecular mechanisms involved in these processes in skeletal muscle cells. |
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| 18950855 | Egawa M, Kamata H, Kushiyama A, Sakoda H, Fujishiro M, Horike N, Yoneda M, Nakatsu Y, Ying G, Jun Z, Tsuchiya Y, Takata K, Kurihara H, Asano T: Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells. Placenta. 2008 Dec;29(12):1003-8. Epub 2008 Oct 23. |
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| 19169664 | Coletta DK, Sriwijitkamol A, Wajcberg E, Tantiwong P, Li M, Prentki M, Madiraju M, Jenkinson CP, Cersosimo E, Musi N, Defronzo RA: stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial. Diabetologia. 2009 Apr;52(4):723-32. Epub 2009 Jan 24. Following insulin-stimulated disposal increased by 30% (p < 0.01), and muscle AMPK and carboxylase (ACC) phosphorylation increased by 38% and 53%, respectively (p < 0.05). |
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| 18469022 | Stoppa GR, Cesquini M, Roman EA, Prada PO, Torsoni AS, Romanatto T, Saad MJ, Velloso LA, Torsoni MA: Intracerebroventricular injection of inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling. J Endocrinol. 2008 Jul;198(1):157-68. Epub 2008 May 9. |
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| 18339363 | Gybina AA, Prohaska JR: Copper deficiency results in AMP-activated protein kinase activation and acetylCoA carboxylase phosphorylation in rat cerebellum. Brain Res. 2008 Apr 14;1204:69-76. Epub 2008 Feb 13. AMP-activated protein kinase (AMPK) is a cellular energy sensor that is activated during mitochondrial inhibition and shuts down biosynthetic processes to help conserve cellular ATP levels. |
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| 18669938 | Branvold DJ, Allred DR, Beckstead DJ, Kim HJ, Fillmore N, Condon BM, Brown JD, Sudweeks SN, Thomson DM, Winder WW: Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle. J Appl Physiol. 2008 Oct;105(4):1218-27. Epub 2008 Jul 31. |
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| 18687367 | Thors B, Halldorsson H, Jonsdottir G, Thorgeirsson G: Mechanism of thrombin mediated eNOS phosphorylation in endothelial cells is dependent on ATP levels after stimulation. Biochim Biophys Acta. 2008 Oct;1783(10):1893-902. Epub 2008 Jul 18. We examined the involvement of two upstream kinases in AMPK activation in cultured human umbilical endothelial cells, LKB1 stimulated by a rise in intracellular AMP/ATP ratio, and Ca (+2)/CaM kinase kinase (CaMKK) responding to elevation of intracellular Ca (+2). |
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| 19716700 | Ha do T, Tuan DT, Thu NB, Nhiem NX, Ngoc TM, Yim N, Bae K: Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate uptake and synthesis via activation of AMPK in insulin-resistant human HepG2 Cells. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5556-9. Epub 2009 Aug 15. |
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| 20054491 | Seo E, Park EJ, Joe Y, Kang S, Kim MS, Hong SH, Park MK, Kim DK, Koh H, Lee HJ: Overexpression of AMPKalpha1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats. Korean J Physiol Pharmacol. 2009 Dec;13(6):449-54. Epub 2009 Dec 31. 5'-AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic (alpha) and two regulatory (beta and gamma) subunits. |
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| 19520133 | Kong CS, Kim JA, Kim SK: Anti-obesity effect of sulfated by AMPK signal pathway in 3T3-L1 adipocytes. Food Chem Toxicol. 2009 Oct;47(10):2401-6. Epub 2009 Jun 9. |
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| 18761357 | Rodriguez A, Catalan V, Becerril S, Gil MJ, Mugueta C, Gomez-Ambrosi J, Fruhbeck G: Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats. Life Sci. 2008 Oct 10;83(15-16):540-9. Epub 2008 Aug 14. |
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| 20041784 | Cho K, Kim SJ, Park SH, Kim S, Park T: Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. J Med Food. 2009 Dec;12(6):1293-301. Moreover, -induced decreases in the ratio of phospho-5'-AMP-activated protein kinase (AMPK) alpha/AMPKalpha and phospho-ACC/ACC protein levels in the liver were significantly restored (135% and 35% increases, respectively, P < .05) by supplementing them with C. lanceolata root water extract. |
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| 19828681 | Jiang S, Wang Z, Riethoven JJ, Xia Y, Miner J, Fromm M: activates AMP-activated protein kinase and reduces adiposity more effectively when used with in mice. J Nutr. 2009 Dec;139(12):2244-51. Epub 2009 Oct 14. The hypotheses of this study were that t10c12 CLA treatment activated AMP-activated protein kinase (AMPK) and that the effectiveness of a low dose of t10c12 CLA would be increased when combined with an AMPK activator. |
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| 17706943 | Favero CB, Mandell JW: A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. Brain Res. 2007 Sep 7;1168:1-10. Epub 2007 Jul 27. |
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| 19698760 | Roman EA, Reis D, Romanatto T, Maimoni D, Ferreira EA, Santos GA, Torsoni AS, Velloso LA, Torsoni MA: Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Mol Cell Endocrinol. 2010 Jan 15;314(1):62-9. Epub 2009 Aug 19. |
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| 19429014 | Jeon BT, Lee DH, Kim KH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS: Ketogenic diet attenuates kainic acid-induced hippocampal cell death by decreasing AMPK/ACC pathway activity and HSP70. Neurosci Lett. 2009 Mar 27;453(1):49-53. Epub 2009 Jan 31. There are reports that AMP-activated protein kinase (AMPK) activation regulates the intracellular signaling pathways involved in cellular survival or apoptotic cell death. |
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| 19914257 | Ceylan-Isik AF, Zhao P, Zhang B, Xiao X, Su G, Ren J: Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis. J Mol Cell Cardiol. 2010 Feb;48(2):367-78. Epub 2009 Nov 13. LPS activated AMPK and its downstream signaling ACC in conjunction with an elevated AMP/ATP ratio, which was unaffected by MT. |
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| 18485240 | Germani D, Puglianiello A, Cianfarani S: Uteroplacental insufficiency down regulates insulin receptor and affects expression of key enzymes of long-chain fatty acid (LCFA) metabolism in skeletal muscle at birth. Cardiovasc Diabetol. 2008 May 18;7:14. Muscle of the posterior limb was dissected at birth and processed by real-time RT-PCR to analyze the expression of insulin receptor, ACCalpha, ACCbeta (acetyl-CoA carboxylase alpha and beta subunits), ACS (acyl-CoA synthase), AMPK (AMP-activated protein kinase, alpha2 catalytic subunit), CPT1B palmitoyltransferase-1 beta subunit), MCD (malonyl-CoA decarboxylase) in 14 sham and 8 IUGR pups. |
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| 17577393 | Esfandiari F, You M, Villanueva JA, Wong DH, French SW, Halsted CH: attenuates hepatic lipid synthesis in micropigs fed with a -deficient diet. Alcohol Clin Exp Res. 2007 Jul;31(7):1231-9. CONCLUSIONS: feeding with a -deficient diet stimulates hepatic lipid synthesis by down-regulating adiponectin-mediated pathways of p-AMPK to increase the expression of nSREBP-1c and its targeted lipogenic enzymes. |
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| 18790741 | Stuck BJ, Lenski M, Bohm M, Laufs U: Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase. J Biol Chem. 2008 Nov 21;283(47):32562-9. Epub 2008 Sep 12. Here we investigate the effect of angiotensin II on and fatty acid utilization and the modifying role of AMP-activated protein kinase (AMPK), a key regulator of metabolism and proliferation. |
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| 18599796 | Li X, Han Y, Pang W, Li C, Xie X, Shyy JY, Zhu Y: AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1789-95. Epub 2008 Jul 3. We investigated the role of AMP-activated protein kinase (AMPK) in EPC differentiation and functions. |
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| 19926919 | Okazaki Y, Eto K, Yamashita T, Okamoto M, Ohsugi M, Noda M, Terauchi Y, Ueki K, Kadowaki T: Decreased insulin secretion and accumulation of triglyceride in beta cells overexpressing a dominant-negative form of AMP-activated protein kinase. Endocr J. 2010;57(2):141-52. Epub 2009 Nov 19. 5' -monophosphate-activated protein kinase (AMPK) has been implicated in the regulation of energy metabolism, although its role in the pancreatic beta cells remains unclear. |
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| 19447226 | Murase T, Misawa K, Haramizu S, Hase T: -induced activation of the LKB1/AMP-activated protein kinase pathway. Biochem Pharmacol. 2009 Jul 1;78(1):78-84. Epub 2009 Mar 31. To clarify the underlying molecular mechanisms of these actions, we examined the effect of catechins on AMP-activated protein kinase (AMPK) in cultured cells and in mice. |
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| 19646421 | Brown RE, Wilkinson PM, Imran SA, Wilkinson M: Resistin differentially modulates neuropeptide gene expression and AMP-activated protein kinase activity in N-1 hypothalamic neurons. Brain Res. 2009 Oct 19;1294:52-60. Epub 2009 Jul 29. NPY, POMC) and influence the activity of novel metabolic enzymes (e.g. 5'AMP-activated protein kinase; AMPK) in the rodent brain. |
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| 18719599 | Lane MD, Wolfgang M, Cha SH, Dai Y: Regulation of food intake and energy expenditure by hypothalamic Int J Obes. 2008 Sep;32 Suppl 4:S49-54. Recent evidence suggests that the changes of hypothalamic during feeding and fasting cycles are caused by changes in the phosphorylation state and activity of ACC mediated via 5'-AMP-activated protein kinase (AMPK). |
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| 18460326 | Sleeman MW, Latres E: The CAMplexities of central ghrelin. . Cell Metab. 2008 May;7(5):361-2. The gut hormone ghrelin is known to activate hypothalamic AMPK, a crucial metabolic sensor controlling energy balance. In this issue of Cell Metabolism, Anderson et al. (2008) show that CaMKK2 mediates this effect by forming a unique complex of AMPKalpha/beta with carboxylase (ACC) in a pathway distinct from the more established /LKB1 pathway. |
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| 17639303 | Han R, Lai R, Ding Q, Wang Z, Luo X, Zhang Y, Cui G, He J, Liu W, Chen Y: Apolipoprotein A-I stimulates AMP-activated protein kinase and improves metabolism. Diabetologia. 2007 Sep;50(9):1960-8. Epub 2007 Jul 18. METHODS: The effects of APOA-I on phosphorylation of AMP-activated protein kinase (AMPK) and carboxylase (ACC), uptake and endocytosis were analysed in C2C12 myocytes. |
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| 19268361 | Zhu MJ, Du M, Nijland MJ, Nathanielsz PW, Hess BW, Moss GE, Ford SP: Down-regulation of growth signaling pathways linked to a reduced cotyledonary vascularity in placentomes of over-nourished, obese pregnant ewes. Placenta. 2009 May;30(5):405-10. Epub 2009 Mar 6. AMP-activated protein kinase (AMPK) is known to sensitize cells to insulin/IGF-1 signaling. |
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| 19444233 | Hattori A, Mawatari K, Tsuzuki S, Yoshioka E, Toda S, Yoshida M, Yasui S, Furukawa H, Morishima M, Ono K, Ohnishi T, Nakano M, Harada N, Takahashi A, Nakaya Y: Beta-adrenergic-AMPK pathway phosphorylates carboxylase in a high- rat model, SPORTS. Obesity (Silver Spring). 2010 Jan;18(1):48-54. Epub 2009 May 14. Recent reports show that Epi activates (AMP)-activated protein kinase (AMPK) in adipocytes. |
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| 18502256 | Koshinaka K, Sano A, Howlett KF, Yamazaki T, Sasaki M, Sakamoto K, Kawanaka K: Effect of high-intensity intermittent swimming on postexercise insulin sensitivity in rat epitrochlearis muscle. Metabolism. 2008 Jun;57(6):749-56. A bout of prolonged aerobic exercise can enhance the sensitivity of muscle uptake to insulin, and this may be mediated by activation of 5'--activated protein kinase (AMPK). |
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| 18501890 | Li HB, Ge YK, Zheng XX, Zhang L: Salidroside stimulated uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol. 2008 Jul 7;588(2-3):165-9. Epub 2008 Apr 20. In summary, AMPK activation was involved in the effects of salidroside on transport activation and insulin sensitivity. |
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| 19913068 | Kang C, Jin YB, Lee H, Cha M, Sohn ET, Moon J, Park C, Chun S, Jung ES, Hong JS, Kim SB, Kim JS, Kim E: Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways. Food Chem Toxicol. 2010 Feb;48(2):509-16. Epub 2009 Nov 11. |
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| 17909224 | Perrone CE, Mattocks DA, Hristopoulos G, Plummer JD, Krajcik RA, Orentreich N: restriction effects on 11 -HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue. J Lipid Res. 2008 Jan;49(1):12-23. Epub 2007 Oct 1. ACC-phosphorylated sites were specific for AMP-activated protein kinase (AMPK); therefore, AMPK activation was evaluated. |
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| 19717488 | Fuentes T, Ara I, Guadalupe-Grau A, Larsen S, Stallknecht B, Olmedillas H, Santana A, Helge JW, Calbet JA, Guerra B: Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance. Exp Physiol. 2010 Jan;95(1):160-71. Epub 2009 Aug 28. To examine whether obesity-associated leptin resistance could be due to down-regulation of leptin receptors (OB-Rs) and/or up-regulation of suppressor of cytokine signalling 3 (SOCS3) and protein tyrosine phosphatase 1B (PTP1B) in skeletal muscle, which blunt janus kinase 2-dependent leptin signalling and signal transducer and activator of transcription 3 (STAT3) phosphorylation and reduce AMP-activated protein kinase (AMPK) and carboxylase (ACC) phosphorylation. |
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| 18534630 | Cesquini M, Stoppa GR, Prada PO, Torsoni AS, Romanatto T, Souza A, Saad MJ, Velloso LA, Torsoni MA: diminishes hypothalamic carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in homeostasis in rats. Life Sci. 2008 Jun 20;82(25-26):1262-71. Epub 2008 May 6. The hypothalamic AMP-activated protein kinase (AMPK)/ carboxylase (ACC) pathway is known to play an important role in the control of food intake and energy expenditure. |
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| 19030775 | Lee JY, Jeon BT, Shin HJ, Lee DH, Han JY, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS: Temporal expression of AMP-activated protein kinase activation during the kainic acid-induced hippocampal cell death. J Neural Transm. 2009 Jan;116(1):33-40. Epub 2008 Nov 22. There are reports that AMP-activated protein kinase (AMPK), which is an important regulator of energy homeostasis of cells, has been proposed as apoptotic molecule. |
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| 18992226 | Hwang SL, Kim HN, Jung HH, Kim JE, Choi DK, Hur JM, Lee JY, Song H, Song KS, Huh TL: Beneficial effects of on and lipid metabolism in L6 myotube cells are mediated by AMP-activated protein kinase. Biochem Biophys Res Commun. 2008 Dec 26;377(4):1253-8. Epub 2008 Nov 4. AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that has been implicated as a key factor for controlling intracellular lipids and metabolism. |
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| 19265677 | Lane MD, Cha SH: Effect of and on food intake via signaling in the brain. Biochem Biophys Res Commun. 2009 Apr 24;382(1):1-5. Epub 2009 Mar 3. AMPK and to the orexigenic/anorexigenic neuropeptide system that determines hunger and energy expenditure. |
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| 18681908 | Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Wang WJ, Song X, Chu WM, Kouttab N, Xu A, Wan Y: SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. J Cell Mol Med. 2009 Sep;13(9B):3632-43. Epub 2008 Aug 4. We also found that SIRT1 is involved in UV-induced AMP-activated protein kinase (AMPK) and downstream carboxylase (ACC), phosphofructose kinase-2 (PFK-2) phosphorylation. |
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| 19116374 | Lombardi A, de Lange P, Silvestri E, Busiello RA, Lanni A, Goglia F, Moreno M: rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement. Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E497-502. Epub 2008 Dec 30. T (2) was able to 1) activate the AMPK-ACC- metabolic signaling pathway known to direct lipid partitioning toward oxidation and 2) increase the importing of fatty acids into the mitochondrion. |
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| 19394382 | Masuzaki H, Tanaka T, Ebihara K, Hosoda K, Nakao K: Hypothalamic melanocortin signaling and leptin resistance--perspective of therapeutic application for obesity-diabetes syndrome. Peptides. 2009 Jul;30(7):1383-6. Epub 2009 Apr 23. We found that the activity of skeletal muscle AMP-activated protein kinase (AMPK) parallels hypothalamic leptin sensitivity and metabolic phenotype in transgenic mice overexpressing leptin. |
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| 18068666 | Kohno D, Sone H, Minokoshi Y, Yada T: Ghrelin raises [Ca2+] i via AMPK in hypothalamic arcuate nucleus NPY neurons. Biochem Biophys Res Commun. 2008 Feb 8;366(2):388-92. Epub 2007 Dec 7. |
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| 19960007 | Zou F, Mao XQ, Wang N, Liu J, Ou-Yang JP: Astragalus polysaccharides alleviates toxicity and restores homeostasis in diabetic states via activation of AMPK. Acta Pharmacol Sin. 2009 Dec;30(12):1607-15. |
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| 18059585 | Han B, Zhu MJ, Ma C, Du M: Rat hindlimb unloading down-regulates insulin like growth factor-1 signaling and AMP-activated protein kinase, and leads to severe atrophy of the soleus muscle. Appl Physiol Nutr Metab. 2007 Dec;32(6):1115-23. The objective of this study was to show the effect of hindlimb unloading on IGF-1 signaling and AMP-activated protein kinase (AMPK) activity in rat soleus and extensor digitorum longus (EDL) muscles. |
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| 19548584 | Qin H, Li Y, Shi L, Sun C: [Effect of t10, c12- on fatty acid metabolism in C2C12 myotubes]. Wei Sheng Yan Jiu. 2009 May;38(3):355-8. A series of enzymes related to fatty acid metabolism, together with AMP-activated protein kinase (AMPK), were determined by western blot. |
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| 18314006 | Pang J, Choi Y, Park T: Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: potential role of AMPK in the visceral adipose tissue. Arch Biochem Biophys. 2008 Aug 15;476(2):178-85. Epub 2008 Feb 26. |
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| 19874425 | Rattan R, Giri S, Hartmann L, Shridhar V: attenuates ovarian cancer cell growth in an AMP- kinase dispensable manner. J Cell Mol Med. 2009 Oct 29. ABSTRACT the most widely used drug for type 2 diabetes activates AMP-activated protein kinase (AMPK), which regulates cellular energy metabolism. |
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| 19001513 | Richardson MC, Ingamells S, Simonis CD, Cameron IT, Sreekumar R, Vijendren A, Sellahewa L, Coakley S, Byrne CD: Stimulation of lactate production in human granulosa cells by and potential involvement of 5' monophosphate-activated protein kinase. J Clin Endocrinol Metab. 2009 Feb;94(2):670-7. Epub 2008 Nov 11. OBJECTIVE: The aim of the study was to examine the action of on GC lactate production and potential mediation via AMP-activated protein kinase (AMPK). |
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| 18070748 | Moon HS, Chung CS, Lee HG, Kim TG, Choi YJ, Cho CS: Inhibitory effect of (-)- on lipid accumulation of 3T3-L1 cells. Obesity (Silver Spring). 2007 Nov;15(11):2571-82. Western blot analysis was used to detect -activated protein kinase (AMPK) activation and phosphorylation of its substrate, carboxylase (ACC), and expression of insulin (INS) receptor, INS receptor substrate-1 (IRS-1), and adipocyte marker proteins. |
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| 19665995 | Kim T, Davis J, Zhang AJ, He X, Mathews ST: activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. Biochem Biophys Res Commun. 2009 Oct 16;388(2):377-82. Epub 2009 Aug 8. |
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| 20110356 | Hao W, Chang CP, Tsao CC, Xu J: Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization. J Biol Chem. 2010 Jan 28. Under the OXPHOS suppression, AMPK regulates global metabolism adjustments but its activation has been found to be transient. |
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