| Name | IDDM |
|---|---|
| Synonyms | IDDM; IDDM 1; IDDM1; IDDM 2; IDDM2; ILPR; insulin dependent diabetes mellitus 2; insulin dependent diabetes mellitus 2s |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10657849 | Conroy SJ, Abdel-Wahab YH, Caraher EM, Byrne PM, Murphy E, Nolan J, Flatt PR, Newsholme P: Evidence for complement-dependent and -independent inhibition of insulin secretion from clonal beta-cells incubated in the presence of sera of newly diagnosed IDDM patients. J Endocrinol. 2000 Feb;164(2):139-47. |
6(0,0,0,6) | Details |
| 11729828 | Kretowski A, Mysliwiec J, Szelachowska M, Brzozowski C, Pietruczuk M, Kinalska I: In vitro secretion of interleukin 2 and expression of IL-2 receptor in peripheral blood lymphocytes in high risk of insulin-dependent diabetes mellitus subjects. Arch Immunol Ther Exp. 1999;47(1):45-9. In the previous studies increased, decreased and unchanged IL-2 levels in patients with recent onset of insulin-dependent diabetes mellitus (IDDM) were found. |
5(0,0,0,5) | Details |
| 9562346 | Savola K, Bonifacio E, Sabbah E, Kulmala P, Vahasalo P, Karjalainen J, Tuomilehto-Wolf E, Merilainen J, Akerblom HK, Knip M: IA-2 antibodies--a sensitive marker of IDDM with clinical onset in childhood and adolescence. Diabetologia. 1998 Apr;41(4):424-9. |
5(0,0,0,5) | Details |
| 10909282 | Kretowski A, Kowalska I, Peczynska J, Urban M, Kinalska I: [IA-2 and anti-GAD antibodies in patients with newly diagnosed type 1 diabetes and their first degree relatives]. Przegl Lek. 2000;57(3):143-6. Antibodies recognising different pancreatic autoantigens (Abs) are detected many years before the clinical onset of insulin-dependent diabetes mellitus (IDDM). |
4(0,0,0,4) | Details |
| 9594623 | Yokota I, Shima K: [GAD antibody in IDDM] . Rinsho Byori. 1998 Apr;46(4):331-7. |
4(0,0,0,4) | Details |
| 9844045 | Sarugeri E, Dozio N, Belloni C, Meschi F, Pastore MR, Bonifacio E: Autoimmune responses to the beta cell autoantigen, insulin, and the INS VNTR-IDDM2 locus. Clin Exp Immunol. 1998 Dec;114(3):370-6. |
4(0,0,0,4) | Details |
| 10714434 | Kretowski A, Maciej K, Ida K: The analysis of in vitro transforming growth factor-beta1 (TGF-beta1) production by peripheral blood in overt and pre-clinical type 1 diabetes mellitus. Immunol Lett. 2000 Feb 1;71(2):85-9. The alterations of TGF-beta1 production are believed to contribute to the development of insulin-dependent diabetes mellitus (IDDM) in animal models as well as in humans. |
4(0,0,0,4) | Details |
| 9649953 | Yamada H, Uchigata Y, Kawasaki E, Matsuura N, Otani T, Sato A, Mutoh K, Kasahara T, Fukushima N, Koike A, Mizota M, Miura J, Kubo H, Yamaguchi A, Nagataki S, Omori Y, Iwamoto Y: Onset age-dependent variations of three islet specific autoantibodies in Japanese IDDM patients. Diabetes Res Clin Pract. 1998 Mar;39(3):211-7. |
3(0,0,0,3) | Details |
| 9790518 | Leinonen JS, Alho H, Harmoinen A, Lehtimaki T, Knip M: Unaltered antioxidant activity of plasma in subjects at increased risk for IDDM. Free Radic Res. 1998 Aug;29(2):159-64. |
3(0,0,0,3) | Details |
| 11192752 | Cinek O, Pechova M, Kolouskova S, Horka I, Sedlakova P, Sumnik Z, Snajderova M, Vavrinec J: [Autoantibodies to GAD65, IA2 and insulin in Czech children with type 1 diabetes]. Cas Lek Cesk. 2000 Sep 27;139(19):599-603. BACKGROUND: Autoimmune insulitis leading to insulin dependent diabetes mellitus (IDDM, Type 1 Diabetes) is accompanied by autoantibodies as its invaluable markers. |
3(0,0,0,3) | Details |
| 10916559 | Krokowski M, Abel M, Teodorczyk A, Szadkowska A, Pyrzak B, Rymkiewicz-Kluczynska B, Bodalski J: Type 1 diabetes and prediabetic state in a monozygotic triplet. Acta Genet Med Gemellol. 1998;47(3-4):171-6. Type 1 diabetes mellitus (IDDM) results from a chronic process of autoimmune destruction of beta cells of the Langerhans islets. |
3(0,0,0,3) | Details |
| 10209508 | Sabbah E, Savola K, Kulmala P, Reijonen H, Veijola R, Vahasalo P, Karjalainen J, Ilonen J, Akerblom HK, Knip M: Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Clin Exp Immunol. 1999 Apr;116(1):78-83. |
3(0,0,0,3) | Details |
| 10909610 | Lazar D, Weintrob N, Abramov N, Assa S, Bloch K, Ofan R, Ben-Zaken H, Vardi P: [Islet autoantibody assays in type I diabetes: superiority of passage from use of ICA to traditional tests]. Harefuah. 1998 May 1;134(9):678-81 In the past decade biochemically-defined beta-cell antigens were described, leading to the development of sensitive and specific autoantibody assays, to predict insulin-dependent diabetes mellitus (IDDM). |
3(0,0,0,3) | Details |
| 9165225 | Schloot NC, Roep BO, Wegmann D, Yu L, Chase HP, Wang T, Eisenbarth GS: Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects. Diabetologia. 1997 May;40(5):564-72. Insulin-dependent diabetes mellitus (IDDM) is the result of a T-cell mediated autoimmune beta-cell destruction, which is accompanied by autoantibodies. |
3(0,0,0,3) | Details |
| 9137938 | Fuchtenbusch M, Karges W, Standl E, Dosch HM, Ziegler AG: Antibodies to bovine serum albumin (BSA) in type 1 diabetes and other autoimmune disorders. Exp Clin Endocrinol Diabetes. 1997;105(2):86-91. Clinical and experimental studies have delineated a link between dietary cow milk protein and the development of insulin-dependent diabetes mellitus (IDDM), and bovine serum albumin (BSA) was proposed as one candidate mediator of this effect. |
3(0,0,0,3) | Details |
| 9405028 | Hartling SG, Knip M, Roder ME, Dinesen B, Akerblom HK, Binder C: Longitudinal study of fasting proinsulin in 148 siblings of patients with insulin-dependent diabetes mellitus. Eur J Endocrinol. 1997 Nov;137(5):490-4. OBJECTIVE: To follow proinsulin immunoreactive material (PIM) in healthy siblings from the time of diagnosis of insulin-dependent diabetes mellitus (IDDM) in the proband, for at least 2 years. |
3(0,0,0,3) | Details |
| 9433472 | Rulli M, Kuusisto A, Salo J, Kojola H, Simell O: Time-resolved fluorescence imaging in islet cell autoantibody quantitation. J Immunol Methods. 1997 Oct 27;208(2):169-79. The prodromal period of insulin-dependent diabetes mellitus (IDDM) is characterized by circulating islet cell autoantibodies (ICA) and other beta cell specific autoantibodies. |
3(0,0,0,3) | Details |
| 12635478 | Kulaeva TL, Titovich EV, Zil'berman LI, Nosikov VV, Peterkova VA, Dedov II: [Genetic and immunologic aspects of type 1 diabetes mellitus] . Usp Fiziol Nauk. 2003 Jan-Mar;34(1):45-62. Prediction of type 1 diabetes mellitus (IDDM) and its identification in preclinical period is one of the central problems in modern medicine. |
3(0,0,0,3) | Details |
| 9568692 | Dittler J, Seidel D, Schenker M, Ziegler AG: GADIA2-combi determination as first-line screening for improved prediction of type 1 diabetes in relatives. Diabetes. 1998 Apr;47(4):592-7. Twenty-four relatives progressed to IDDM within a median follow-up time of 5.6 years (range 0.5-8.2). |
2(0,0,0,2) | Details |
| 9435304 | Kulmala P, Savola K, Petersen JS, Vahasalo P, Karjalainen J, Lopponen T, Dyrberg T, Akerblom HK, Knip M: Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. J Clin Invest. 1998 Jan 15;101(2):327-36. An unselected population of 755 siblings of children with insulin-dependent diabetes mellitus (IDDM) was studied to evaluate the predictive characteristics of islet cell antibodies (ICA), antibodies to the IA-2 protein (IA-2A), antibodies to the 65-kD isoform of glutamic acid decarboxylase (GADA), insulin autoantibodies (IAA), and combinations of these markers. |
2(0,0,0,2) | Details |
| 10612480 | Jaeger C, Hatziagelaki E, Stroedter A, Becker F, Scherer S, Petzoldt R, Federlin K, Bretzel RG: The Giessen-Bad Oeynhausen family study: improved prediction of type I diabetes in a low incidence population of relatives using combinations of islet autoantibodies in a dual step model. Exp Clin Endocrinol Diabetes. 1999;107(8):496-505. In accordance with the Cox model, relatives with more than one affected family member (a multiplex pedigree) and siblings and offsprings vs. parents were at increased risk of IDDM (p < 0.05). |
2(0,0,0,2) | Details |
| 10615825 | Kinalski M, Kretowski A: [The changes in the humoral immune system during pregnancy with diabetes] . Ginekol Pol. 1999 Oct;70(10):800-6. It is now possible, on the basis of the presence of antibodies directed against pancreatic autoantigens (ICA, GADA, IA-2A, IAA) to detect in the early stage of the autoimmune process leading to development of insulin-dependent diabetes (IDDM). |
2(0,0,0,2) | Details |
| 9316771 | House DV, Winter WE: Autoimmune diabetes. Clin Lab Med. 1997 Sep;17(3):499-545. At the present time, we know much more about the prediction of IDDM than its prevention. |
2(0,0,0,2) | Details |
| 9662050 | Naserke HE, Dozio N, Ziegler AG, Bonifacio E: Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay. Diabetologia. 1998 Jun;41(6):681-3. IAA were measured with both assays in samples from 94 new onset insulin-dependent diabetes mellitus (IDDM) patients, 97 control subjects. and 48 first degree relatives of IDDM patients selected for having IAA in the conventional radiobinding assay. |
2(0,0,0,2) | Details |
| 15699505 | Perez de Nanclares G, Bilbao JR, Castano L: No association of INS-VNTR genotype and IAA autoantibodies. Ann N Y Acad Sci. 2004 Dec;1037:127-30. Genetic susceptibility to type 1 diabetes is polygenic and includes the INS VNTR-IDDM2 locus, which has been shown to regulate the expression of insulin in the pancreas and thymus. |
2(0,0,0,2) | Details |
| 10424434 | Kretowski A, Mysliwiec J, Szelachowska M, Turowski D, Wysocka J, Kowalska I, Kinalska I: Gammadelta T-cells alterations in the peripheral blood of high risk diabetes type 1 subjects with subclinical pancreatic B-cells impairment. Immunol Lett. 1999 Jun 1;68(2-3):289-93. In conclusion, the study suggests that the gammadelta T-cells play an important role in the development of insulin-dependent diabetes mellitus (IDDM). |
2(0,0,0,2) | Details |
| 9628241 | Breidert M, Temelkova-Kurktschiev T, Hanefeld M, Leonhardt W, Schmoeckel A, Seissler J: Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus. Exp Clin Endocrinol Diabetes. 1998;106(2):113-6. To evaluate the potential of autoimmune markers in identifying patients with slowly progressive IDDM in the prediabetic state, we screened a population of 151 patients aged 37-70 years with impaired glucose tolerance (IGT) for the presence of islet cell antibodies (ICA), insulin autoantibodies (IAA), antibodies to glutamic acid decarboxylase (GADA), and antibodies to phosphatase IA-2 (IA-2A). |
1(0,0,0,1) | Details |
| 9376075 | Williams AJ, Bingley PJ, Bonifacio E, Palmer JP, Gale EA: A novel micro-assay for insulin autoantibodies. J Autoimmun. 1997 Oct;10(5):473-8. Using this assay 126 out of 241 (52%) newly diagnosed IDDM patients (median age 10.2, range 1.3-20.7 years) had IAA levels above the 99th centile of 2860 schoolchildren (median age 11.3, range 9.0-13.8 years), including 81 out of 117 (69%) patients below the age of 10 years. |
1(0,0,0,1) | Details |
| 9137905 | Ongagna JC, Levy-Marchal C: Sensitivity at diagnosis of combined beta-cell autoantibodies in insulin-dependent diabetic children. Diabetes Metab. 1997 Apr;23(2):155-60. French Registry of IDDM in Children Study Group.. |
1(0,0,0,1) | Details |
| 17461431 | Rajasalu T, Haller K, Salur L, Kisand K, Tillmann V, Schlosser M, Uibo R: Insulin VNTR I/III genotype is associated with autoantibodies against glutamic acid decarboxylase in newly diagnosed type 1 diabetes. Diabetes Metab Res Rev. 2007 Oct;23(7):567-71. BACKGROUND: In type 1 diabetes (T1D), the influence of age at diagnosis and of the IDDM1 and IDDM2 genetic susceptibility loci on the profile of beta-cell autoantibodies has been demonstrated. |
1(0,0,0,1) | Details |
| 9179462 | Ludvigsson J, Hellstrom S: Autoantibodies in relation to residual insulin secretion in children with IDDM. Diabetes Res Clin Pract. 1997 Mar;35(2-3):81-9. |
1(0,0,0,1) | Details |
| 9614927 | Kopchaliiska D, Stamenova M, Manolova V, Kehayov I, Dakovska L, Kyurkchiev S: Cross-reacting idiotypes on anti-insulin autoantibodies in autoimmune diseases, identified by monoclonal antibodies. Clin Immunol Immunopathol. 1998 May;87(2):130-8. These idiotypes are detected in sera from patients with insulin-dependent diabetes mellitus (IDDM), which are IAA-negative, also. |
1(0,0,0,1) | Details |
| 9754810 | Schmidli RS, Colman PG, Cui L, Yu WP, Kewming K, Jankulovski C, Harrison LC, Pallen CJ, DeAizpurua HJ: Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM. Autoimmunity. 1998;28(1):15-23. |
10(0,0,0,10) | Details |
| 9353155 | Van der Auwera BJ, Vandewalle CL, Schuit FC, Winnock F, De Leeuw IH, Van Imschoot S, Lamberigts G, Gorus FK: CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. Clin Exp Immunol. 1997 Oct;110(1):98-103. |
6(0,0,0,6) | Details |
| 9167107 | Christie MR, Roll U, Payton MA, Hatfield EC, Ziegler AG: Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care. 1997 Jun;20(6):965-70. OBJECTIVE: To determine whether screening for the presence of multiple antibody markers for IDDM is effective at identifying individuals with high risk for disease development. |
6(0,0,0,6) | Details |