| Name | chloride channel (protein family or complex) |
|---|---|
| Synonyms | chloride channel |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9518703 | Doughty JM, Miller AL, Langton PD: Non-specificity of chloride channel blockers in rat cerebral arteries: block of the L-type calcium channel. J Physiol. 1998 Mar 1;507 ( Pt 2):433-9. |
5(0,0,0,5) | Details |
| 11891568 | Eskandari S, Zampighi GA, Leung DW, Wright EM, Loo DD: Inhibition of gap junction hemichannels by chloride channel blockers. J Membr Biol. 2002 Jan 15;185(2):93-102. Epub 2002 Feb 5. |
3(0,0,0,3) | Details |
| 17041730 | Wang YZ, Liu ZJ, Li L, Fan P, Si JQ, Zhao L, Ma KT, Zhu L, Gao WJ: [Effects of chloride channel blockers on excitatory junction potentials in smooth muscle cells of cochlear spiral modiolar artery in guinea pigs]. Sheng Li Xue Bao. 2006 Oct 25;58(5):456-62. |
3(0,0,0,3) | Details |
| 9150469 | Reeves WB: Effects of chloride channel blockers on hypoxic injury in rat proximal tubules. Kidney Int. 1997 May;51(5):1529-34. |
2(0,0,0,2) | Details |
| 15184393 | Berryman M, Bruno J, Price J, Edwards JC: CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo. J Biol Chem. 2004 Aug 13;279(33):34794-801. Epub 2004 Jun 7. |
2(0,0,0,2) | Details |
| 9263908 | Nelson MT, Conway MA, Knot HJ, Brayden JE: Chloride channel blockers inhibit myogenic tone in rat cerebral arteries. J Physiol. 1997 Jul 15;502 ( Pt 2):259-64. |
2(0,0,0,2) | Details |
| 10205144 | Diaz RJ, Losito VA, Mao GD, Ford MK, Backx PH, Wilson GJ: Chloride channel inhibition blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium. Circ Res. 1999 Apr 16;84(7):763-75. |
1(0,0,0,1) | Details |
| 12160963 | Batthish M, Diaz RJ, Zeng HP, Backx PH, Wilson GJ: Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition. Cardiovasc Res. 2002 Aug 15;55(3):660-71. |
1(0,0,0,1) | Details |
| 10555568 | Nabel C, Schweda F, Riegger GA, Kramer BK, Kurtz A: Chloride channel blockers attenuate the inhibition of renin secretion by angiotensin II. Pflugers Arch. 1999 Oct;438(5):694-9. |
1(0,0,0,1) | Details |
| 10495853 | Hashimoto S: [The in vivo role of vascular channels in the regulation of glomerular hemodynamics]. Hokkaido Igaku Zasshi. 1999 Sep;74(5):387-94. The (Ca2+)-dependent chloride channel (CIC) may have a crucial role in the modulation of the effects of Angiotensin II (AII) on vascular smooth muscle cell and glomerular mesangium. |
3(0,0,0,3) | Details |
| 17347778 | Edwards JC: The CLIC1 chloride channel is regulated by the cystic fibrosis transmembrane conductance regulator when expressed in Xenopus oocytes. J Membr Biol. 2006;213(1):39-46. Epub 2007 Mar 8. |
1(0,0,0,1) | Details |
| 11113003 | Heusch G, Liu GS, Rose J, Cohen MV, Downey JM: No confirmation for a causal role of volume-regulated channels in ischemic preconditioning in rabbits. J Mol Cell Cardiol. 2000 Dec;32(12):2279-85. That current could be blocked by the selective chloride channel blockers 5-nitro-2-(3-phenylpropylamino) (NPPB) or indanyloxyacetic acid 94 (IAA-94), but only at 100 microM and 1 m M respectively. |
1(0,0,0,1) | Details |
| 9746517 | Pollock NS, Kargacin ME, Kargacin GJ: Chloride channel blockers inhibit Ca2+ uptake by the smooth muscle sarcoplasmic reticulum. Biophys J. 1998 Oct;75(4):1759-66. |
1(0,0,0,1) | Details |
| 11090834 | Tabrizchi R, Duggan JA: The interrelationship between ions and endothelium on alpha (1)-adrenoceptor-mediated contractions in aortic rings from Dahl normotensive and hypertensive rats. Cardiovasc Res. 2000 Dec;48(3):393-401. OBJECTIVES: The effects of -free buffer in the absence or presence of the synthase inhibitor, N (omega)-nitro- methyl ester (L-NAME), or chloride channel antagonist, indanyloxyacetic acid 94 (IAA-94) on alpha (1)-adrenoceptor mediated contractions were investigated in aortic rings from Dahl salt-resistant normotensive (SRN) and salt-sensitive hypertensive (SSH) rats on a 4% salt diet. |
1(0,0,0,1) | Details |
| 17565566 | Hansen PB, Friis UG, Uhrenholt TR, Briggs J, Schnermann J: Intracellular signalling pathways in the vasoconstrictor response of mouse afferent arterioles to Acta Physiol. 2007 Oct;191(2):89-97. Epub 2007 Jun 12. The -activated chloride channel inhibitor IAA-94 (30 microM) inhibited the -mediated constriction. |
1(0,0,0,1) | Details |
| 14506073 | Steendahl J, Holstein-Rathlou NH, Sorensen CM, Salomonsson M: Effects of chloride channel blockers on rat renal vascular responses to angiotensin II and Am J Physiol Renal Physiol. 2004 Feb;286(2):F323-30. Epub 2003 Sep 23. |
1(0,0,0,1) | Details |
| 18278453 | Li J, Wu X, Cui T: Functional characteristics and molecular identification of swelling-activated conductance in adult rabbit heart ventricles. J Huazhong Univ Sci Technolog Med Sci. 2008 Feb;28(1):37-41. Candidate chloride channel clones (e.g. |
1(0,0,0,1) | Details |
| 18164246 | d'Anglemont de Tassigny A, Berdeaux A, Souktani R, Henry P, Ghaleh B: The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2. Eur J Heart Fail. 2008 Jan;10(1):39-46. |
1(0,0,0,1) | Details |
| 14679313 | Hashimoto S, Kawata T, Schnermann J, Koike T: Chloride channel blockade attenuates the effect of angiotensin II on tubuloglomerular feedback in WKY but not spontaneously hypertensive rats. Kidney Blood Press Res. 2004;27(1):35-42. Epub 2003 Dec 16. We investigated the effect of the -dependent chloride channel blocker IAA-94 on renal hemodynamics and TGF responses. |
1(0,0,0,1) | Details |
| 9037434 | Hubschle T, Madeja M, Musshoff U, Speckmann EJ: Membrane currents elicited by the organic calcium channel blocker in native and rat brain RNA-injected oocytes of Xenopus laevis. Arzneimittelforschung. 1997 Jan;47(1):1-5. Under the influence of potassium channel blockers (tetraethylammonium and cesium or chloride channel blockers (anthracene-9- and the indanyloxy- derivative IAA-94) the induced currents were reduced. |
1(0,0,0,1) | Details |
| 19446535 | Kjaer K, Strobaek D, Christophersen P, Ronn LC: Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 2009 Jul 24;1281:15-24. Epub 2009 May 13. Here we investigate the effects of established chloride channel blockers with different chemical structures on interferon-gamma (IFNgamma)-induced activation of the murine microglial cell line, BV2. |
1(0,0,0,1) | Details |
| 14718479 | Matchkov VV, Aalkjaer C, Nilsson H: A cyclic GMP-dependent -activated current in smooth-muscle cells from rat mesenteric resistance arteries. J Gen Physiol. 2004 Feb;123(2):121-34. Epub 2004 Jan 12. It was inhibited by and zinc ions in the micromolar range, but was unaffected by and had a low sensitivity to inhibition by the chloride channel blockers niflumic acid, DIDS, and IAA-94. |
1(0,0,0,1) | Details |
| 10523296 | Szabo I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M: Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. EMBO J. 1999 Oct 15;18(20):5517-27. VacA-dependent increase of current conduction both in artificial planar lipid bilayers and in the cellular system was effectively inhibited by the chloride channel blocker 5-nitro-2-(3-phenylpropylamino) (NPPB), while2-[(2-cyclopentenyl-6,7dichloro-2, 3-dihydro-2-methyl-1-oxo-1H-inden-5-yl) oxy] (IAA-94) was less effective. |
1(0,0,0,1) | Details |