| Name | protein tyrosine phosphatase |
|---|---|
| Synonyms | DUSP16; DUSP16 protein; Dual specificity phosphatase 16; Dual specificity protein phosphatase 16; MAP kinase phosphatase 7; MAPK phosphatase 7; MKP 7; MKP7… |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18176860 | Taplin CE, Barker JM: Autoantibodies in type 1 diabetes. Autoimmunity. 2008 Feb;41(1):11-8. Subsequently, antibodies to insulin (IAA), glutamic acid decarboxylase (GAA or GAD) and protein tyrosine phosphatase (IA2 or ICA512) have all been defined. |
1(0,0,0,1) | Details |
| 10209508 | Sabbah E, Savola K, Kulmala P, Reijonen H, Veijola R, Vahasalo P, Karjalainen J, Ilonen J, Akerblom HK, Knip M: Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Clin Exp Immunol. 1999 Apr;116(1):78-83. The possible relation between HLA-DQ genotypes and both frequencies and levels of autoantibodies associated with IDDM was assessed by examining HLA-DQB1 alleles and antibodies to islet cells (ICA), insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tyrosine phosphatase-related IA-2 molecule (IA-2A) in 631 newly diagnosed diabetic children under the age of 15 years. |
1(0,0,0,1) | Details |
| 16514546 | Bingley PJ, Gale EA: Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk. Diabetologia. 2006 May;49(5):881-90. Epub 2006 Mar 3. OGTTs and IVGTTs were performed at baseline, antibodies to decarboxylase (GADA), protein tyrosine phosphatase (IA-2A) and insulin (IAA) were determined by RIA, and HLA class II genotyping was performed by PCR of sequence-specific oligonucleotides. |
1(0,0,0,1) | Details |
| 16061004 | Zhang C, Zhou ZG, Zhang DM, Yang XL, Zhou M, Lin J, Huang G, Wang JP: [Clinical and immunological characteristics in rapid-onset type 1 diabetes with hyperamylasemia]. Zhonghua Yi Xue Za Zhi. 2005 Apr 13;85(14):967-71. Islet autoantibodies, including glutamic acid decarboxylase antibody (GAD-Ab), protein tyrosine phosphatase antibody (IA-2Ab) and insulin autoantibody (IAA),, were detected by radioligand assays. |
1(0,0,0,1) | Details |
| 15386804 | Larsson K, Elding-Larsson H, Cederwall E, Kockum K, Neiderud J, Sjoblad S, Lindberg B, Lernmark B, Cilio C, Ivarsson SA, Lernmark A: Genetic and perinatal factors as risk for childhood type 1 diabetes. Diabetes Metab Res Rev. 2004 Nov-Dec;20(6):429-37. Cord blood is analysed for HLA high-risk alleles and for autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GADA), the protein tyrosine phosphatase-related IA-2 antigen (IA-2A) and insulin (IAA) as a measure of prenatal autoimmune exposure. |
1(0,0,0,1) | Details |
| 14679044 | Schlosser M, Wassmuth R, Strebelow M, Rjasanowski I, Ziegler M: Multiple and high-titer single autoantibodies in schoolchildren reflecting the genetic predisposition for type 1 diabetes. Ann N Y Acad Sci. 2003 Nov;1005:98-108. AAbs against glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA-2A), and insulin (IAA) were determined by (125) I-antigen binding, and islet cell cytoplasmic antibodies (ICAs) immunohistochemically. |
1(0,0,0,1) | Details |
| 9754810 | Schmidli RS, Colman PG, Cui L, Yu WP, Kewming K, Jankulovski C, Harrison LC, Pallen CJ, DeAizpurua HJ: Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM. Autoimmunity. 1998;28(1):15-23. |
2(0,0,0,2) | Details |
| 15588983 | Meng TC, Hsu SF, Tonks NK: Development of a modified in-gel assay to identify protein tyrosine phosphatases that are oxidized and inactivated in vivo. Methods. 2005 Jan;35(1):28-36. |
2(0,0,0,2) | Details |
| 10909282 | Kretowski A, Kowalska I, Peczynska J, Urban M, Kinalska I: [IA-2 and anti-GAD antibodies in patients with newly diagnosed type 1 diabetes and their first degree relatives]. Przegl Lek. 2000;57(3):143-6. The aim of the study was the estimation of the prevalence and titre of the antibodies directed against protein tyrosine phosphatase-2 (IA-2) and glutamic acid decarboxylase (GAD) in patients with newly diagnosed diabetes type 1 and their first degree relatives. |
1(0,0,0,1) | Details |
| 15508807 | Szepietowska B, Szelachowska M, Gorska M, Jakubczyk D, Kinalska I: [Chronic complications in adult patients with newly diagnosed diabetes mellitus in relation to the presence of humoral autoimmune markers against pancreatic islet cells]. Pol Arch Med Wewn. 2004 May;111(5):563-9. decarboxylase antibodies (anti-GAD), protein tyrosine phosphatase antibodies (anti-IA-2) and anti-insulin antibodies (IAA) titers were measured by RIA. |
1(0,0,0,1) | Details |
| 9353155 | Van der Auwera BJ, Vandewalle CL, Schuit FC, Winnock F, De Leeuw IH, Van Imschoot S, Lamberigts G, Gorus FK: CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. Clin Exp Immunol. 1997 Oct;110(1):98-103. In a registry-based group of 525 recent-onset IDDM patients <40 years old we investigated the possible interactions of a CTLA-4 gene A-to-G transition polymorphism with age at clinical disease onset and with the presence or absence of established genetic (HLA-DQ, INS VNTR) and immune disease markers (autoantibodies against islet cell cytoplasm (ICA); insulin (IAA); decarboxylase (GAD65-Ab); IA-2 protein tyrosine phosphatase (IA-2-Ab)) determined within the first week of insulin treatment. |
1(0,0,0,1) | Details |
| 10479394 | Sera Y, Kawasaki E, Abiru N, Ozaki M, Abe T, Takino H, Kondo H, Yamasaki H, Yamaguchi Y, Akazawa S, Nagataki S, Uchigata Y, Matsuura N, Eguchi K: Autoantibodies to multiple islet autoantigens in patients with abrupt onset type 1 diabetes and diabetes diagnosed with urinary screening. J Autoimmun. 1999 Sep;13(2):257-65. To elucidate the associations of expression of autoantibodies to multiple islet antigens with age of onset and mode of diagnosis of diabetes in Japanese patients with type 1 diabetes, autoantibodies against the protein tyrosine phosphatase-like molecules ICA512 (IA-2) and phogrin (IA-2beta) (ICA512/phogrin-A), GAD (GADA), insulin (IAA), and islet cell cytoplasm (ICA) were determined in sera from 73 Japanese patients with type 1 diabetes obtained within 14 days of diagnosis. |
1(0,0,0,1) | Details |
| 16442659 | Holmberg H, Vaarala O, Sadauskaite-Kuehne V, Ilonen J, Padaiga Z, Ludvigsson J: Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes. Diabetes Res Clin Pract. 2006 Jun;72(3):308-14. Epub 2006 Jan 26. We analyzed autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tyrosine phosphatase like IA-2 (IA-2A) as well as risk-associated polymorphisms of HLA, insulin and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) genes. |
1(0,0,0,1) | Details |
| 15016155 | Borg H, Marcus C, Sjoblad S, Fernlund P, Sundkvist G: Insulin autoantibodies are of less value compared with islet antibodies in the clinical diagnosis of autoimmune type 1 diabetes in children older than 3 yr of age. Pediatr Diabetes. 2002 Sep;3(3):149-54. OBJECTIVE: To relate IAA to islet antibodies (i.e., islet cell antibodies [ICA], and antibodies against two ICA-related islet antigens, glutamic acid decarboxylase 65 [GADA] and protein tyrosine phosphatase IA-2 [IA-2 A]) at diagnosis, and to endogenous beta-cell function at follow-up after diagnosis in diabetic children. |
1(0,0,0,1) | Details |
| 15826926 | Falorni A, Brozzetti A: Diabetes-related antibodies in adult diabetic patients. Best Pract Res Clin Endocrinol Metab. 2005 Mar;19(1):119-33. Islet autoimmunity is made evident by the appearance of islet-cell antibodies directed against insulin (IAA), glutamic acid decarboxylase (GADA), protein tyrosine phosphatase IA-2 (IA-2Ab) and other autoantigens. |
1(0,0,0,1) | Details |
| 15699502 | Schlosser M, Strebelow M, Rjasanowski I, Kerner W, Wassmuth R, Ziegler M: Prevalence of diabetes-associated autoantibodies in schoolchildren: the Karlsburg Type 1 Diabetes Risk Study. Ann N Y Acad Sci. 2004 Dec;1037:114-7. This study attempts to assess the prevalence of diabetes-associated autoantibodies in a general population in the northeastern part of Germany, with emphasis on autoantibodies against glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA-2A), and insulin (IAA) by radioassays >/= 98th percentile, and AAbs binding on pancreatic sections (ICA) by immunofluorescence >/= 10 Juvenile Diabetes Foundation units. |
1(0,0,0,1) | Details |
| 11600541 | Kimpimaki T, Kupila A, Hamalainen AM, Kukko M, Kulmala P, Savola K, Simell T, Keskinen P, Ilonen J, Simell O, Knip M: The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab. 2001 Oct;86(10):4782-8. If an infant seroconverted to ICA positivity, all his/her samples were also analyzed for insulin autoantibodies (IAA), antibodies to the 65-kDa isoform of glutamic acid decarboxylase, and antibodies to the protein tyrosine phosphatase-related IA-2 molecule. |
1(0,0,0,1) | Details |
| 16614815 | Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J: Lymphoid phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes. Diabetologia. 2006 Jun;49(6):1198-208. Epub 2006 Apr 14. AIMS/HYPOTHESIS: We analysed the contribution of the lymphoid protein tyrosine phosphatase (LYP) Arg620Trp variant (which corresponds to the PTPN22 C1858T polymorphism) to the emergence of beta-cell-specific humoral autoimmunity and progression to type 1 diabetes in man. |
1(0,0,0,1) | Details |
| 10382585 | Strebelow M, Schlosser M, Ziegler B, Rjasanowski I, Ziegler M: Karlsburg Type I diabetes risk study of a general population: frequencies and interactions of the four major Type I diabetes-associated autoantibodies studied in 9419 schoolchildren. Diabetologia. 1999 Jun;42(6):661-70. METHODS: We took capillary serum from 9419 schoolchildren, aged 6-17 years, for testing of autoantibodies (AAbs) to glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA2A) and insulin (IAA) by 125I-antigen binding. |
1(0,0,0,1) | Details |
| 11921419 | Hamalainen AM, Ilonen J, Simell O, Savola K, Kulmala P, Kupila A, Simell T, Erkkola R, Koskela P, Knip M: Prevalence and fate of type 1 diabetes-associated autoantibodies in cord blood samples from newborn infants of non-diabetic mothers. Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):57-63. METHODS: The samples were analysed for cytoplasmic islet cell antibodies (ICA), autoantibodies to the 65 kD isoform of glutamic acid decarboxylase (GADA), autoantibodies to the protein tyrosine phosphatase related IA-2 antigen (IA-2A), insulin autoantibodies (IAA) and HLA DQB1 genotypes. |
1(0,0,0,1) | Details |
| 18588707 | Murgia C, Orru M, Portoghese E, Garau N, Zedda P, Berria R, Motzo C, Sulis S, Murenu M, Paoletti AM, Melis GB: Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report. Reprod Biol Endocrinol. 2008 Jun 29;6:24. METHODS: We determined glutamic decarboxylase antibodies (anti-GAD65), protein tyrosine phosphatase ICA 512 (IA2) antibodies (anti-IA2), and IAA in 62 GDM patients, and in 56 controls with matching age, gestational age and parity. |
1(0,0,0,1) | Details |
| 15895384 | Franke B, Galloway TS, Wilkin TJ: Developments in the prediction of type 1 diabetes mellitus, with special reference to insulin autoantibodies. Diabetes Metab Res Rev. 2005 Sep-Oct;21(5):395-415. The major target antigens are islet-cell antigen, glutamic acid decarboxylase (GAD), protein-tyrosine phosphatase-2 (IA-2) and insulin. |
1(0,0,0,1) | Details |
| 18036312 | Wang JP, Zhang C, Lin J, Yuan Y, Zhou HF, Huang G, Zhou M, Zhou ZG: [Relationship between autoantibodies and HLA-DQ genotypes in patients with type 1 diabetes mellitus]. Zhonghua Yi Xue Za Zhi. 2007 Sep 11;87(34):2380-4. OBJECTIVE: To explore the relationship between the 3 islet autoantibodies, i.e., glutamic acid decarboxylase antibody (GADA), protein-tyrosine-phosphatase-2 autoantibody (IA-2A), and insulin autoantibody (IAA), and human leukocyte HLA-DQ genotypes in the patients with type 1 diabetes mellitus (T1DM). |
1(0,0,0,1) | Details |
| 18416318 | Primo ME, Niepomniszcze H, Poskus E, Sala MS, Guaita SS, Sica MP, Villalba A, Cardoso A, Bruno OD: Frequency of pancreatic beta-cell autoimmunity markers in patients with autoimmune thyroid disease. Medicina (B Aires). 2008;68(1):37-42. Screening for markers of pancreatic beta-cell autoimmunity was performed by radioligand binding assays (RBA) as follows: autoantibodies to glutamic acid decarboxylase (GADA) and proinsulin (PAA) were determined in all sera, whereas autoantibodies to protein tyrosine phosphatase (IA-2A) and insulin (IAA) were additionally measured in 200 sera randomly selected from the total collection. |
1(0,0,0,1) | Details |
| 11683397 | Valdez SN, Sica MP, Labovsky V, Iacono RF, Cardoso AL, Krochik AG, Mazza CS, Ermacora MR, Cedola N, Poskus E: Combined measurement of diabetes mellitus immunological markers: an assessment of its benefits in adult-onset patients. Autoimmunity. 2001;33(4):227-36. The convenience of combining the measurement of antibodies to glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA-2A), and autoantibodies to insulin (IAA) in diabetic patients was assessed. |
1(0,0,0,1) | Details |
| 9433472 | Rulli M, Kuusisto A, Salo J, Kojola H, Simell O: Time-resolved fluorescence imaging in islet cell autoantibody quantitation. J Immunol Methods. 1997 Oct 27;208(2):169-79. Despite biochemical characterization of the major beta cell autoantigens insulin, glutamic acid decarboxylase and protein tyrosine phosphatase and development of the respective antibody assays, ICA has remained the standard in IDDM prediction. |
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