| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | deltamethrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12232873 | Bouvier JC, Boivin T, Beslay D, Sauphanor B: Age-dependent response to insecticides and enzymatic variation in susceptible and resistant codling moth larvae. Arch Insect Biochem Physiol. 2002 Oct;51(2):55-66. The aim of this study was to follow the age variations in larval susceptibility to deltamethrin and teflubenzuron in one susceptible (S) strain, and two resistant (Rv and Rt) ones selected for resistance to deltamethrin and diflubenzuron, respectively. The age variation of the activities of cytochrome P450-dependent monooxygenase (MFO), glutathione S-transferases (GST), and esterases in S and both resistant strains were simultaneously investigated. |
1(0,0,0,1) | Details |
| 15788727 | Vinggaard AM, Christiansen S, Laier P, Poulsen ME, Breinholt V, Jarfelt K, Jacobsen H, Dalgaard M, Nellemann C, Hass U: Perinatal exposure to the fungicide prochloraz feminizes the male rat offspring. Toxicol Sci. 2005 Jun;85(2):886-97. Epub 2005 Mar 23. In addition cytochrome P450 (CYP) 1A activities in livers were induced by prochloraz, possibly as a result of Ah receptor activation. The purpose of this study was to investigate reproductive toxic effects after exposure during gestation and lactation to prochloraz alone and a mixture of five pesticides (deltamethrin, methiocarb, prochloraz, simazine, and tribenuron-methyl). |
1(0,0,0,1) | Details |
| 8980024 | Thomas JD, Ottea JA, Boethel DJ, Ibrahim S: Factors Influencing Pyrethroid Resistance in a Permethrin-Selected Strain of the Soybean Looper, Pseudoplusia includens (Walker). Pestic Biochem Physiol. 1996 May;55(1):1-9. Cytochrome P450 monooxgenase activity toward p-nitroanisole was measured in larvae of three strains of soybean looper, Pseudoplusia includens (Walker), including a laboratory susceptible (S) strain, a resistant (R) strain selected for several generations with permethrin, and a nonselected (NS) strain from the same field collections as the R strain. Resistance to the alpha-cyano pyrethroids deltamethrin and cypermethrin was similar to or higher than that observed with permethrin (RR = 70.0, 62.4, 145.3 and 12.1, 32.3, and 27.0 for permethrin, deltamethrin, and cypermethrin in R and NS strains, respectively). |
1(0,0,0,1) | Details |
| 19728321 | Zhou X, Ma C, Li M, Sheng C, Liu H, Qiu X: CYP9A12 and CYP9A17 in the cotton bollworm, Helicoverpa armigera: sequence similarity, expression profile and xenobiotic response. Pest Manag Sci. 2010 Jan;66(1):65-73. The authors attempt to identify new cytochrome P450 genes and investigate their expression profile and xenobiotic response in order to understand the nature and roles of cytochrome P450s in this important pest.RESULTS: A novel P450 cDNA (CYP9A17), encoding a protein of 531 amino acid residues, was isolated from H. armigera. Real-time quantitative RT-PCR showed that the level of both CYP9A12 and CYP9A17 mRNA is affected in dose-dependent and tissue-specific manners by deltamethrin, gossypol and phenobarbital.CONCLUSION: CYP9A12 and CYP9A17 showed high sequence identity, but with differential expression patterns, suggesting that CYP9A12 and CYP9A17 genes in H. armigera might diverge via subfunctionalisation after the gene duplication event. |
1(0,0,0,1) | Details |
| 18179425 | Muller P, Chouaibou M, Pignatelli P, Etang J, Walker ED, Donnelly MJ, Simard F, Ranson H: Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in Anopheles arabiensis sampled from an area of cotton fields in Northern Cameroon. Mol Ecol. 2008 Feb;17(4):1145-55. Epub 2007 Dec 20. The tolerance of the malaria vector, Anopheles arabiensis to deltamethrin was determined in a field population from a cotton-growing region of Northern Cameroon both prior to and midway through the 4-month period of insecticide application to the cotton crop. Several genes with antioxidant roles, including superoxide dismutases, a glutathione S-transferase and a thioredoxin-dependent peroxidase, and a cytochrome P450 showed elevated expression in mosquito families collected during the insecticide-spraying programme. |
1(0,0,0,1) | Details |
| 11233122 | Kranthi KR, Jadhav D, Wanjari R, Kranthi S, Russell D: Pyrethroid resistance and mechanisms of resistance in field strains of Helicoverpa armigera (Lepidoptera: Noctuidae). J Econ Entomol. 2001 Feb;94(1):253-63. Studies carried out through estimation of detoxification enzyme activity and synergists indicated that enhanced cytochrome p450 and esterase activities were probably important mechanisms for pyrethroid resistance in field strains. Resistance to deltamethrin was exceptionally high with resistance ratios of 13,570 and 27,160 in two strains collected during February 1998 in central India. |
1(0,0,0,1) | Details |
| 15825765 | Rodpradit P, Boonsuepsakul S, Chareonviriyaphap T, Bangs MJ, Rongnoparut P: Cytochrome P450 genes: molecular cloning and overexpression in a pyrethroid-resistant strain of Anopheles minimus mosquito. J Am Mosq Control Assoc. 2005 Mar;21(1):71-9. Using semiquantitative reverse transcription-polymerase chain reaction analysis, the mRNA expression level of CYP6P7 presented approximately 2- and 4-fold increases in F19 and F25 deltamethrin-resistant populations, respectively, compared with the parent susceptible strain. |
1(0,0,0,1) | Details |
| 15912569 | Espinosa PJ, Contreras J, Quinto V, Gravalos C, Fernandez E, Bielza P: Metabolic mechanisms of insecticide resistance in the western flower thrips, Frankliniella occidentalis (Pergande). Pest Manag Sci. 2005 Oct;61(10):1009-15. The interactions between six insecticides (methiocarb, formetanate, acrinathrin, deltamethrin, methamidophos and endosulfan) and three potential synergists (piperonyl butoxide (PBO), S,S,S-tributyl phosphorotrithioate (DEF) and diethyl (DEM)) were studied by topical exposure in strains selected for resistance to each insecticide, and in a susceptible strain of Frankliniella occidentalis (Pergande). These studies indicate that an enhanced detoxification, mediated by cytochrome P-450 monooxygenases, is the major mechanism imparting resistance to different insecticides in F occidentalis. |
1(0,0,0,1) | Details |
| 19326768 | Das PC, Streit TM, Cao Y, Rose RL, Cherrington N, Ross MK, Wallace AD, Hodgson E: Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36. Deltamethrin [(S)-alpha-cyano-3-phenoxybenzyl-cis-(1 R,3R)-3 (2,2-dibromovinyl)(2,2-dimethyl-cyclopropane-carboxylate] and permethrin [3-phenoxybenzyl (1RS)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopr opanecarboxylate] are pyrethroid insecticides used in agriculture, public health and military deployments. Pyrethroids are known to be capable of inducing cytochrome P450 (CYP) 2B1/2B2, CYP1A1 and overall CYP content in rat liver. |
1(0,0,0,1) | Details |
| 2632242 | Catinot R, Hoellinger H, Pfister A, Sonnier M, Simon MT: Effects on rats of subacute intoxication with deltamethrin via an osmotic pump. Drug Chem Toxicol. 1989 Sep-Dec;12(3-4):173-96. Cytochrome P-450, cytochrome b5, -cytochrome c reductase, esterases and the activities of six mixed function oxidases were assayed. |
1(0,0,0,1) | Details |
| 16831841 | Mirfazaelian A, Kim KB, Anand SS, Kim HJ, Tornero-Velez R, Bruckner JV, Fisher JW: Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male Sprague-Dawley rat. Toxicol Sci. 2006 Oct;93(2):432-42. Epub 2006 Jul 10. Cytochrome P450-mediated metabolism was accounted for in the liver and carboxylesterase (CaE)-mediated metabolism in plasma and liver. |
1(0,0,0,1) | Details |
| 14642741 | Atsriku C, Watson DG, Grant MH, Skellern GG: The effect of inducing agents on the metabolism of trypanocidal diamidines by isolated rat hepatocytes. Chem Biol Interact. 2003 Dec 15;146(3):297-305. This study has investigated the effect of phenobarbitone (PB), 3-methylcholanthrene (3-MC), and deltamethrin (DM) on the metabolism of two trypanocidal diamidines; pentamidine isethionate and diminazene in freshly isolated Sprague-Dawley rat hepatocytes. |
0(0,0,0,0) | Details |
| 11455663 | Juliet S, Chakraborty AK, Koley KM, Mandal TK, Bhattacharyya A: Toxico-kinetics, recovery efficiency and microsomal changes following administration of deltamethrin to black Bengal goats. Pest Manag Sci. 2001 Mar;57(3):311-9. A study of the toxico-kinetics, recovery percentage from different substrates, cytotoxicity and role of cytochrome P450 and b5 of liver microsome in the metabolism of deltamethrin were carried out in female black Bengal goat. |
162(2,2,2,2) | Details |
| 20235118 | Sarapusit S, Pethuan S, Rongnoparut P: Mosquito -cytochrome P450 oxidoreductase: kinetics and role of amino acid substitutions at leu86 and leu219 in CYP6AA3-mediated deltamethrin metabolism. Arch Insect Biochem Physiol. 2010 Apr;73(4):232-44. The single mutant (L86F or L219F) and double mutant (L86F/L219F) flAnCYPOR enzymes, upon reconstitution with the An. minimus cytochrome P450 CYP6AA3 and a -regenerating system, increased CYP6AA3-mediated deltamethrin degradation compared to the wild-type flAnCYPOR enzyme. |
85(1,1,1,5) | Details |
| 16169030 | Anand SS, Bruckner JV, Haines WT, Muralidhara S, Fisher JW, Padilla S: Characterization of deltamethrin metabolism by rat plasma and liver microsomes. Toxicol Appl Pharmacol. 2006 Apr 15;212(2):156-66. Epub 2005 Sep 16. Liver microsomal CYP450-mediated biotransformation of deltamethrin was a higher capacity (Vmax=2611.3+/-134.1 nmol/h/g liver) and higher affinity (Km=74.9+/-5.9 microM) process than carboxylesterase (plasma or liver) detoxification. |
83(1,1,1,3) | Details |
| 9887680 | Stuart JJ, Ray S, Harrington BJ, Neal JJ, Beeman RW: Genetic mapping of a major locus controlling pyrethroid resistance in Tribolium castaneum (Coleoptera: Tenebrionidae). J Econ Entomol. 1998 Dec;91(6):1232-8. Piperonyl butoxide, an inhibitor of cytochrome P450-mediated oxidative metabolism, significantly increased the toxicity of deltamethrin to a strain derived from QTC279 that carries PyR-1, strain pR. |
82(1,1,1,2) | Details |
| 12371615 | Varanka Z, Deer KA, Rojik I, Varanka I, Laszlo K, Bartok T, Nemcsok J, Abraham M: Influence of the polyphenolic tannic acid on the toxicity of the insecticide deltametihrin to fish. Acta Biol Hung. 2002;53(3):351-65. Deltamethrin, applied in a very low dose, induced oxyradical production in fish via activation of cytochrome P450 isozymes. |
81(1,1,1,1) | Details |
| 16494911 | Johri A, Dhawan A, Lakhan Singh R, Parmar D: Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cytochrome P450s in the brain and liver of offsprings. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):279-89. Epub 2006 Feb 21. Prenatal exposure to low doses (0.25 or 0.5 or 1.0 mg/kg, p.o.) of deltamethrin, a type II pyrethroid insecticide, to pregnant dams from gestation days 5 to 21 (GD5-21) produced dose-dependent alterations in the ontogeny of xenobiotic metabolizing cytochrome P450 (CYP) isoforms in brain and liver of the offsprings. |
81(1,1,1,1) | Details |
| 11948970 | Kumar S, Thomas A, Sahgal A, Verma A, Samuel T, Pillai MK: Effect of the synergist, piperonyl butoxide, on the development of deltamethrin resistance in yellow fever mosquito, Aedes aegypti L. (Diptera: Culicidae). Arch Insect Biochem Physiol. 2002 May;50(1):1-8. The data indicate the involvement of cytochrome P450-dependent detoxification as the primary mechanism of development of resistance to deltamethrin in the larvae. |
81(1,1,1,1) | Details |
| 16859670 | Johri A, Yadav S, Singh RL, Dhawan A, Ali M, Parmar D: Long lasting effects of prenatal exposure to deltamethrin on cerebral and hepatic cytochrome P450s and behavioral activity in rat offspring. Eur J Pharmacol. 2006 Aug 21;544(1-3):58-68. Epub 2006 Jun 27. Dose-dependent alterations in the parameters of spontaneous locomotor activity in the offspring postnatally at 3 weeks have indicated that increase in cytochrome P450 activity may lead to the accumulation of deltamethrin and its metabolites to the levels that may be sufficient to alter the behavioral activity of the offspring. |
37(0,1,2,2) | Details |
| 17576809 | Godin SJ, Crow JA, Scollon EJ, Hughes MF, DeVito MJ, Ross MK: Identification of rat and human cytochrome p450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerate. Drug Metab Dispos. 2007 Sep;35(9):1664-71. Epub 2007 Jun 18. |
31(0,1,1,1) | Details |
| 12567630 | Zhu CL, Li JM, Tian HS, Ma L, Li XL, Wu GL: [Cloning and identification of cytochrome P450 resistance related genes in the mosquito, Culex pipiens pallens]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000;18(5):263-8. OBJECTIVE: To inquire into the relationship between cytochrome P450 and deltamethrin resistance. |
21(0,0,3,6) | Details |
| 14714662 | Rongnoparut P, Boonsuepsakul S, Chareonviriyaphap T, Thanomsing N: Cloning of cytochrome P450, CYP6P5, and CYP6AA2 from Anopheles minimus resistant to deltamethrin. J Vector Ecol. 2003 Dec;28(2):150-8. |
12(0,0,2,2) | Details |
| 12504175 | Dayal M, Parmar D, Dhawan A, Ali M, Dwivedi UN, Seth PK: Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin. Food Chem Toxicol. 2003 Mar;41(3):431-7. |
12(0,0,2,2) | Details |
| 15880260 | Gong MQ, Gu Y, Hu XB, Sun Y, Ma L, Li XL, Sun LX, Sun J, Qian J, Zhu CL: Cloning and overexpression of CYP6F1, a cytochrome P450 gene, from deltamethrin-resistant Culex pipiens pallens. Acta Biochim Biophys Sin. 2005 May;37(5):317-26. |
12(0,0,2,2) | Details |
| 15273811 | Gonzalez Audino P, Vassena C, Barrios S, Zerba E, Picollo MI: Role of enhanced detoxication in a deltamethrin-resistant population of Triatoma infestans (Hemiptera, Reduviidae) from Argentina. Mem Inst Oswaldo Cruz. 2004 May;99(3):335-9. Epub 2004 Jul 19. These results suggest that degradative esterases (no-cholinesterase) and mono-oxygenases cytochrome p450, play an important role in the resistance to deltamethrin in Salta colony from Argentina. |
7(0,0,1,2) | Details |
| 16952383 | Yadav S, Johri A, Dhawan A, Seth PK, Parmar D: Regional specificity in deltamethrin induced cytochrome P450 expression in rat brain. Toxicol Appl Pharmacol. 2006 Nov 15;217(1):15-24. Epub 2006 Jul 29. |
6(0,0,1,1) | Details |
| 18508027 | Daaboub J, Ben Cheikh R, Lamari A, Ben Jha I, Feriani M, Boubaker C, Ben Cheikh H: Resistance to pyrethroid insecticides in Culex pipiens pipiens (Diptera: Culicidae) from Tunisia. Acta Trop. 2008 Jul;107(1):30-6. Epub 2008 Apr 22. The use of synergists showed that the cytochrome P450-dependent monooxygenases had a major contribution to the permethrin and deltamethrin resistance and that the esterases (and/or glutathione-S-transferases) had only a minor contribution. |
6(0,0,1,1) | Details |
| 18615616 | Boonsuepsakul S, Luepromchai E, Rongnoparut P: Characterization of Anopheles minimus CYP6AA3 expressed in a recombinant baculovirus system. Arch Insect Biochem Physiol. 2008 Sep;69(1):13-21. We previously isolated the cytochrome P450 CYP6AA3 from deltamethrin-selected resistant strain of Anopheles minimus mosquito, a major malaria vector in Thailand. |
6(0,0,1,1) | Details |
| 9269084 | Banka L, Deer KA, Nemcsok J, Abraham M: In vivo and in vitro effects of deltamethrin on cytochrome P450 monooxygenase activity in carp (Cyprinus carpio L) liver. J Environ Sci Health B. 1997 Sep;32(5):789-802. The in vivo and in vitro effects of the insecticide deltamethrin (DM) on hepatic cytochrome P450 (Cyt P450) monooxygenase were examined in adult carp. |
6(0,0,1,1) | Details |
| 12495187 | Rodriguez MM, Bisset J, Ruiz M, Soca A: Cross-resistance to pyrethroid and organophosphorus insecticides induced by selection with temephos in Aedes aegypti (Diptera: Culicidae) from Cuba. J Med Entomol. 2002 Nov;39(6):882-8. Synergism tests implicated detoxifying esterases in temephos and fenthion resistance and deltamethrin resistance was associated with a cytochrome P450 monooxygenasa. |
6(0,0,1,1) | Details |
| 14715465 | Dayal M, Parmar D, Ali M, Dhawan A, Dwivedi UN, Seth PK: Induction of rat brain cytochrome P450s (P450s) by deltamethrin: regional specificity and correlation with neurobehavioral toxicity. Neurotox Res. 2001 Aug;3(4):351-7. Oral administration of 5 mg/kg body weight of deltamethrin, an alpha-cyano type II pyrethroid insecticide once a day for 1, 7, 15 and 21 consecutive days to young Druckerey rats (6- 8 weeks old) produced a time dependent increase in the activity of cytochrome P450 (P450) dependent 7-ethoxyresorufin-O-deethylase (EROD) and 7-pentoxyresorufin-O-dealkylase (PROD) in rat brain microsomes. |
6(0,0,1,1) | Details |
| 2764708 | Catinot R, Hoellinger H, Sonnier M, Do-Cao-Thang, Pichon J, Nguyen-Hoang-Nam: In vitro covalent binding of the pyrethroids cismethrin, cypermethrin and deltamethrin to rat liver homogenate and microsomes. Arch Toxicol. 1989;63(3):214-20. With microsomes, inhibition of cytochrome P-450 and mixed function oxidases by and piperonyl butoxide reduced the covalent binding so far as to be nearly absent. |
2(0,0,0,2) | Details |
| 9461846 | Bride JM, Cuany A, Amichot M, Brun A, Babault M, Mouel TL, De Sousa G, Rahmani R, Berge JB: Cytochrome P-450 field insecticide tolerance and development of laboratory resistance in grape vine populations of Drosophila melanogaster (Diptera: Drosophilidae). J Econ Entomol. 1997 Dec;90(6):1514-20. Few significant variations of ECOD activity were detected among the natural populations despite many insecticide treatments, but activities were significantly correlated with toxicological tolerance to 5 of the 15 insecticides (deltamethrin, fipronil, chlorpyriphos ethyl, DDT, and diazinon). |
2(0,0,0,2) | Details |
| 17710279 | Dzul FA, Patricia Penilla R, Rodriguez AD: [Susceptibility and insecticide resistance mechanisms in Anopheles albimanus from the southern Yucatan Peninsula, Mexico]. Salud Publica Mex. 2007 Jul-Aug;49(4):302-11. Blanco municipality in Quintana Roo and the Calakmul municipality in Campeche, were exposed to deltamethrin, DDT, pirimiphos-methyl and bendiocarb in susceptibility tests, as well as to biochemical assays in order to calculate the enzyme levels related to insecticide resistance. Biochemical assays showed high levels of glutathione S-transferase (GST), cytochrome P450 and esterases (with pNPA substrate) in all villages. |
2(0,0,0,2) | Details |
| 20183062 | Abass K, Turpeinen M, Pelkonen O: An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. J Environ Sci Health B. 2009 Aug;44(6):553-63. Deltamethrin and fenvalerate were potent inhibitors of CYP2D6 (IC (50) values of approximately 3 micro M) while lambda-cyhalothrin potently inhibited both CYP2D6 and CYP3A4-mediated activities (IC (50)'s about 3-4 micro M). |
1(0,0,0,1) | Details |
| 19298862 | He J, Sun H, Zhang D, Sun Y, Ma L, Chen L, Liu Z, Xiong C, Yan G, Zhu C: Cloning and characterization of 60S ribosomal protein L22 (RPL22) from Culex pipiens pallens. Comp Biochem Physiol B Biochem Mol Biol. 2009 Jun;153(2):216-22. Epub 2009 Mar 17. Real-time quantitative PCR analysis demonstrated that the transcription level of RPL22 in deltamethrin-resistant strain was 2.57 folds higher than in deltamethrin-susceptible strain of Cx. pipiens pallens. The mRNA level of cytochrome P450 6A1 (CYP6A1, GenBank accession no. |
1(0,0,0,1) | Details |