| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | chlorfenvinphos |
|---|---|
| CAS | 2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl phosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9292287 | Worek F, Backer M, Thiermann H, Szinicz L, Mast U, Klimmek R, Eyer P: Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum Exp Toxicol. 1997 Aug;16(8):466-72. These data may help to define more precisely the indications and limitations of oxime therapy in organophosphate (OP) poisoning. 2 Diethylphosphoryl-AChE resulting from intoxications with parathion, chlorpyrifos, chlorfenvinphos, diazinon and other OPs is characterized by slow spontaneous reactivation and low propensity for ageing. |
9(0,0,1,4) | Details |
| 9575664 | Gralewicz S, Socko R: Persisting behavioural and electroencephalographic effects of exposure to chlorphenvinphos, an organophosphorous pesticide, in laboratory animals. Int J Occup Med Environ Health. 1997;10(4):375-94. Their insecticidal properties and acute toxicity in nontarget species derive from the inhibition of acetylcholinesterase (AChE) which disturbs the cholinergically mediated neurotransmission. |
7(0,0,0,7) | Details |
| 10677267 | Dembele K, Haubruge E, Gaspar C: Concentration effects of selected insecticides on brain acetylcholinesterase in the common carp (Cyprinus carpio L.). Ecotoxicol Environ Saf. 2000 Jan;45(1):49-54. Hence, in the present study in vivo exposure period effect and in vitro concentration-response of chlorfenvinphos, chlorpyrifos diazinon, and carbofuran were investigated on Cyprinus carpio L. |
7(0,0,0,7) | Details |
| 3779165 | Hart AD, Westlake GE: Acetylcholinesterase activity and the effects of chlorfenvinphos in regions of the starling brain. Bull Environ Contam Toxicol. 1986 Nov;37(5):774-82. |
6(0,0,1,1) | Details |
| 7446144 | Kisielinski T, Gajewski D, Gidynska T, Owczarczyk H: Antiesterase activity of chlorphenvinphos and phospholine in certain rat tissues after administration by different routes. Acta Physiol Pol. 1980 May-Jun;31(3):279-88. The reported investigations were carried out on female Wistar rats receiving chlorphenvinphos and phospholine in doses equalling 3/4 LD50 onto the skin and intragastrically. the levels of acetylcholinesterase (AChE) were determined in the erythrocytes, liver and tibialis muscle and in three brain areas: pontomedullary area, hypothalamus and cerebral cortex. |
4(0,0,0,4) | Details |
| 7234437 | Gajewski D: Acetylcholinesterase activity in several rat liver cell fractions after repeated poisoning with some organophosphates. Acta Physiol Pol. 1980 Sep-Oct;31(5):575-80. During 28 days the fats were given daily organophosphates (DFP, DDVP, Chlorfenvinphos, IPO-62, IPO-63, Phospholine) in a dose of 1/10 LD50 subcutaneously. |
3(0,0,0,3) | Details |
| 9478091 | Kossmann S, Cierpka E, Szwed Z: Biochemical evaluation of the liver function in workers employed at the production of chlorfenvinphos. Przegl Lek. 1997;54(10):712-5. Serum concentration of protein components and the activity of some selected enzymes--red blood cell acetylcholinesterase (AChE), serum alkaline phosphatase (AP), gamma-glutamyltranspeptydase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and malic dehydrogenase (MDH) were determined in 41 males on the first examination. |
3(0,0,0,3) | Details |
| 10421489 | Richards P, Johnson M, Ray D, Walker C: Novel protein targets for organophosphorus compounds. Chem Biol Interact. 1999 May 14;119-120:503-11. Rates of reaction of these labelling sites with a range of OP compounds were compared to that of acetylcholinesterase. Neither labelling band reacted with chlorfenvinphos or demeton-s-methyl at significant rates. |
3(0,0,0,3) | Details |
| 2340983 | Ikeda T, Kojima T, Yoshida M, Takahashi H, Tsuda S, Shirasu Y: Pretreatment of rats with an organophosphorus insecticide, chlorfenvinphos, protects against subsequent challenge with the same compound. Fundam Appl Toxicol. 1990 Apr;14(3):560-7. Oral treatment of rats with CVP (15 mg/kg) inhibited brain acetylcholinesterase (AChE) activity. |
3(0,0,0,3) | Details |
| 17826976 | Istamboulie G, Andreescu S, Marty JL, Noguer T: Highly sensitive detection of organophosphorus insecticides using magnetic microbeads and genetically engineered acetylcholinesterase. Biosens Bioelectron. 2007 Nov 30;23(4):506-12. Epub 2007 Aug 2. The oriented and site-specific immobilisation combined with the high specificity of the B349 mutant allows a more sensitive detection of insecticides, concentrations as low as 1.31 (-11) M (IC10) being detected for both pesticides chlorpyriphos-oxon and chlorfenvinphos. |
2(0,0,0,2) | Details |
| 19559912 | Istamboulie G, Cortina-Puig M, Marty JL, Noguer T: The use of Artificial Neural Networks for the selective detection of two organophosphate insecticides: chlorpyrifos and chlorfenvinfos. Talanta. 2009 Jul 15;79(2):507-11. Epub 2009 Apr 16. Amperometric acetylcholinesterase (AChE) biosensors have been developed to resolve mixtures of chlorpyrifos oxon (CPO) and chlorfenvinfos (CFV) pesticides. |
2(0,0,0,2) | Details |
| 6732507 | Osicka-Koprowska A, Lipska M, Wysocka-Paruszewska B: Effects of chlorfenvinphos on plasma and levels in rats. Arch Toxicol. 1984 Mar;55(1):68-9. Brain and blood AChE activity was diminished to about 10-30% for up to 24 h, with maximal inhibition in brain at 2 h after treatment. |
2(0,0,0,2) | Details |
| 16201202 | Lutz P, Gralewicz S, Kur B, Wiaderna D: Amphetamine- and -induced locomotor activity following treatment with chlorphenvinphos or chlorphyriphos in rats. Int J Occup Med Environ Health. 2005;18(2):115-25. MATERIALS AND METHODS: CVP and CPF were administered intraperitoneally, both at doses resulting in about 50% inhibition of erythrocyte acetylcholinesterase (rbcAChE). |
2(0,0,0,2) | Details |
| 985225 | Stone BF, Wilson JT, Youlton NJ: Linkage and dominance characteristics of genes for resistance to organophosphorus acaricides and allelic inheritance of decreased brain cholinesterase activity in three strains of the cattle tick, Boophilus microplus. Aust J Biol Sci. 1976 Jul;29(3):251-63. No F1 larval progeny from the following crossings were appreciably more resistant than their parents to these chemicals: R x B--bromophos ethyl and fenthion; B x M--carbaryl, chlorfenvinphos, chlorpyrifos, diazinon, dimethoate, ethion, fenthion and formothion; M x R--chlorfenvinphos, diazinon, dimethoate, ethion, formothion. F1 adult progeny of B x M and R x M crossings exhibited the incompletely recessive mutant-type decreased brain acetylcholinesterase (AChE) activity common to strains B, M and R, thus satisfying the test for allelism. |
2(0,0,0,2) | Details |
| 12201035 | Gralewicz S, Lutz P, Tomas T: Behavioural responsiveness to amphetamine or following repeated exposure to chlorphenvinphos in rats. Acta Neurobiol Exp. 2002;62(2):75-83. A number of reports indicate that exposure to organophosphates (OPs), inhibitors of acetylcholinesterase (AChE), may result in long-lasting neurobehavioural alterations suggestive of an increased cholinergic tone. |
2(0,0,0,2) | Details |
| 15476966 | Foil LD, Coleman P, Eisler M, Fragoso-Sanchez H, Garcia-Vazquez Z, Guerrero FD, Jonsson NN, Langstaff IG, Li AY, Machila N, Miller RJ, Morton J, Pruett JH, Torr S: Factors that influence the prevalence of acaricide resistance and tick-borne diseases. Vet Parasitol. 2004 Oct 28;125(1-2):163-81. Farmers continued to use amitraz as the major acaricide for tick control after the diagnosis of resistance, although it was supplemented with moxidectin (dairy farms) or fluazuron, macrocyclic lactones or cypermethrin/chlorfenvinphos. Acetylcholine esterase affinity for OPs is changed in resistant tick populations. |
2(0,0,0,2) | Details |
| 6514001 | Puzynska L: Relationship between dietary protein level and enzymatic changes in acute poisoning of rats with chlorfenvinphos. Nahrung. 1984;28(8):779-87. Protein deficient diet increased the Chl-produced inhibition of acetylcholinesterase (AChE) activity in the brain; the augmented activity of aspartate aminotransferase (AspAT) and alanine aminotransferase (AlaAT) and glucosephosphate isomerase (PHI) appeared only in the serum of low-protein rats--these changes were more marked in females. |
1(0,0,0,1) | Details |
| 10909176 | Gralewicz S, Lutz P, Szymczak W: Hyposensitivity to amphetamine following exposure to chlorphenvinphos--protection by amphetamine preexposure. Acta Neurobiol Exp. 2000;60(2):203-8. All animals were challenged with 1.0 mg/kg amphetamine (AMPH) three weeks after the CVP exposure, i.e. after a time sufficient for acetylcholinesterase recovery. |
1(0,0,0,1) | Details |
| 6933967 | Brzezinski J, Wysocka-Paruszewska B: Neurochemical alterations in rat brain as a test for studying the neurotoxicity of organophosphorus insecticides. Arch Toxicol Suppl. 1980;4:475-8. Male Wistar rats were acutely and chronically intoxicated with organophosphorus insecticides (OPI)-chlorfenvinphos, dichlorvos and fenitrothion. The effects on brain acetylcholine esterase activity (AChE) and (NE) level were determined. |
1(0,0,0,1) | Details |
| 2453047 | Pawlowska D, Kocmierska-Grodzka D, Moniuszko-Jakoniuk J: The effect of methylbromophenvinfos (Polfos) on some enzymes in vivo and in vitro. Pol J Pharmacol Pharm. 1987 Jul-Aug;39(4):361-70. The activities of cholinesterase (ChE), beta-glucuronidase (beta- lipase and amylase were assayed in the blood serum, the activity of acetylcholinesterase (AChE)-in brain homogenates, and the activities of lipase and amylase-in homogenates of the pancreas. |
1(0,0,0,1) | Details |
| 17128811 | Lutz P, Wiaderna D, Gralewicz S, Kur B: Exposure to chlorphenvinphos, an organophosphate insecticide, prevents from behavioral sensitization to amphetamine. Int J Occup Med Environ Health. 2006;19(2):132-41. OBJECTIVES: Exposure to organophosphorus (OP) pesticides, irreversible inhibitors of acetylcholinesterase (AChE), may result in long-lasting alterations in the functional state of the central nervous system. |
1(0,0,0,1) | Details |
| 11218047 | Dekundy A, Blaszczak P, Kaminski R, Turski WA: On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice. Arch Toxicol. 2001 Jan;74(11):702-8. Both organophosphate (OP) and pesticides may produce seizures and death commonly attributed to the inhibition of acetylcholinesterase (AChE) and subsequent excess of Adult Swiss mice were systemically injected with the OP pesticide, chlorfenvinphos (CVP), or the pesticide, methomyl (MET). |
1(0,0,0,1) | Details |
| 11957784 | Kossmann S, Konieczny B: [Serum immunoglobulin E concentration in workers producing chlorfenvinphos]. Przegl Lek. 2001;58 Suppl 7:49-50. |
0(0,0,0,0) | Details |
| 10353999 | Dembele K, Haubruge E, Gaspar C: Recovery of acetylcholinesterase activity in the common carp (Cyprinus carpio L.) after inhibition by organophosphate and compounds. Bull Environ Contam Toxicol. 1999 Jun;62(6):731-42. |
1(0,0,0,1) | Details |
| 8614665 | Konieczny B: [Evaluation of respiratory tract function in workers employed in the production of Enolophos]. Pneumonol Pol. 1990 Jul-Aug;58(7-8):386-91. In patients with decreased erythrocyte acetylcholinesterase activity only increased airway resistance was seen. |
1(0,0,0,1) | Details |
| 19371264 | Raszewski G, Filip R: Correlation of therapeutic effect of obidoxime and dosing time in the acute intoxication by chlorfenvinphos in rats. Basic Clin Pharmacol Toxicol. 2009 Jul;105(1):37-45. Epub 2009 Apr 3. The ability of obidoxime with atropine and diazepam mixture to reactivate acetylcholinesterase inhibited by the organophosphorus compound chlorfenvinphos was compared in the central nervous system and peripheral tissues of rats. |
163(2,2,2,3) | Details |
| 19159775 | Istamboulie G, Fournier D, Marty JL, Noguer T: Phosphotriesterase: a complementary tool for the selective detection of two organophosphate insecticides: chlorpyrifos and chlorfenvinfos. Talanta. 2009 Mar 15;77(5):1627-31. Epub 2008 Oct 14. This work shows the possibility of combining the high sensitivity of genetically-modified Drosophila melanogaster acetylcholinesterase (B394) with the ability of phosphotriesterase (PTE) to hydrolyse organophosphate compounds, in the aim of developing a biosensor selective to two insecticides of interest: chlorpyrifos and chlorfenvinfos. |
1(0,0,0,1) | Details |
| 17706853 | Lukaszewicz-Hussain A: Subchronic intoxication with chlorfenvinphos, an organophosphate insecticide, affects rat brain antioxidative enzymes and level. Food Chem Toxicol. 2008 Jan;46(1):82-6. Epub 2007 Jul 14. Toxicity of these compounds is mainly due to inhibition of acetylcholinesterase (AChE), but many authors postulate that OP in acute as well as in chronic intoxication disturb the redox processes, changing the activities of antioxidative enzymes and causing enhancement of lipid peroxidation in many organs. |
1(0,0,0,1) | Details |
| 20169407 | Mdegela RH, Mosha RD, Sandvik M, Skaare JU: Assessment of acetylcholinesterase activity in Clarias gariepinus as a biomarker of organophosphate and exposure. Ecotoxicology. 2010 Feb 19. Following exposure of fish to chlorfenvinphos at concentrations above 0.03 muM, a significant inhibition of AChE activities in plasma (84%) and eye homogenate (50%) was observed. |
155(1,3,4,10) | Details |
| 17366566 | Sismeiro-Vivas J, Abrantes N, Pereira JL, Castro BB, Goncalves F: Short-term effects of Quirlan (chlorfenvinphos) on the behavior and acetylcholinesterase activity of Gambusia holbrooki. Environ Toxicol. 2007 Apr;22(2):194-202. A strong inhibition of AChE was observed in fish exposed to chlorfenvinphos (IC50 = 3.55 microg L (-1)). |
90(1,1,2,5) | Details |
| 8783813 | Worek F, Kirchner T, Backer M, Szinicz L: Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Arch Toxicol. 1996;70(8):497-503. For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. |
84(1,1,1,4) | Details |
| 17615116 | Carter WG, Tarhoni M, Rathbone AJ, Ray DE: Differential protein adduction by seven organophosphorus pesticides in both brain and thymus. Hum Exp Toxicol. 2007 Apr;26(4):347-53. We found significant adduction of partially characterized protein targets in both rat brain and thymus by azamethiphos, chlorfenvinphos, chlorpyrifos-oxon, diazinon-oxon, dichlorvos and malaoxon, in vitro and pirimiphos-methyl in vivo. |
0(0,0,0,0) | Details |
| 10384211 | Konieczny B, Kossmann S, Makuch M: Impaired respiratory muscle function in chemical plant workers producing chlorfenvinphos. Ann Agric Environ Med. 1999;6(1):21-5. |
0(0,0,0,0) | Details |
| 18484351 | Tarhoni MH, Lister T, Ray DE, Carter WG: Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers. 2008 Jun;13(4):343-63. At pesticide exposures producing approximately 30% inhibition of AChE, rat plasma albumin binding in vitro by azamethiphos (oxon), chlorfenvinphos (oxon), chlorpyrifos-oxon, diazinon-oxon and malaoxon was reduced from controls by 9+/-1%, 67+/-2%, 56+/-2%, 54+/-2% and 8+/-1%, respectively. |
82(1,1,1,2) | Details |
| 6482945 | Puzynska L: Alterations in some biochemical processes in the organism of rats being under the influence of chlorfenvinphos administered in diets with variable protein content. Nahrung. 1984;28(5):473-82. The decrease of the PHI activity in the brain and the inhibition of acetylcholinesterase activity in the serum and brain depended mainly on the amount of chlorfenvinphos in the diets and to a lower degree on the amount of protein. |
31(0,1,1,1) | Details |
| 15019250 | Rickwood CJ, Galloway TS: Acetylcholinesterase inhibition as a biomarker of adverse effect. Aquat Toxicol. 2004 Mar 30;67(1):45-56. Here, haemolymph AChE activity was combined with biomarkers of cellular integrity, immunotoxicity and physiological status in order to measure exposure to and the effects of the priority pollutant chlorfenvinphos. |
10(0,0,1,5) | Details |