Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
15033010 Chen L, Shi N, Dong J, Li T, Chen D: [Effects of estradiol on deltamethrin-induced neurotoxicity in rat cerebro-cortical synaptosomes]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):22-5.

The activities of 4 kinds of ATPase were inhibited by 2 x 10 (-4) mol/L deltamethrin, and these effects could be blocked by 10 (-5) mol/L estradiol, while the activity of Ca (2+)-ATPase was increased by 10 (-8), 10 (-11) mol/L of estradiol.
174(2,2,4,4) Details
2957417 Sahib IK, Prasada Rao KS, Desaiah D: Pyrethroid inhibition of basal and calmodulin stimulated Ca2+ ATPase and adenylate cyclase in rat brain. J Appl Toxicol. 1987 Apr;7(2):75-80.

None of the pyrethroids inhibited synaptosomal basal Ca2+ ATPase, but permethrin and deltamethrin inhibited basal adenylate cyclase in the nuclear fraction of a brain homogenate.
40(0,1,2,5) Details
2973491 Shaker N, Hassan GA, el-Nouty FD, Abo-Elezz Z, Abd-Allah GA: In vivo chronic effect of dimethoate and deltamethrin on rabbits. J Environ Sci Health B. 1988 Aug;23(4):387-99.

The in vivo effect of dimethoate and deltamethrin on body and organ weights, serum proteins and on plasma acetylcholinesterase (AChE), aromatic esterase and ATPase were examined in growing male rabbits throughout five months period.
13(0,0,2,3) Details
8751838 Husain R, Husain R, Adhami VM, Seth PK: Behavioral, neurochemical, and neuromorphological effects of deltamethrin in adult rats. J Toxicol Environ Health. 1996 Aug 9;48(5):515-26.

The activity of Na+,K (+)-ATPase showed marked decrease in frontal cortex, hippocampus, and cerebellum following deltamethrin exposure.
6(0,0,1,1) Details
6239040 Rao KS, Chetty CS, Desaiah D: In vitro effects of pyrethroids on rat brain and liver ATPase activities. J Toxicol Environ Health. 1984;14(2-3):257-65.

Oligomycin-insensitive Mg2+-ATPase was not affected by any of the compounds tested except deltamethrin, which showed significant effect on liver enzyme.
3(0,0,0,3) Details
8258384 Kodavanti PR, Mundy WR, Tilson HA, Harry GJ: Effects of selected neuroactive chemicals on calcium transporting systems in rat cerebellum and on survival of cerebellar granule cells. Fundam Appl Toxicol. 1993 Oct;21(3):308-16.

Ca2+ extrusion, measured as Ca (2+)-ATPase activity, was determined in synaptosomes prepared by sucrose density gradient.
However, chlorpromazine (CPZ), aluminum (Al), permethrin (PER), and deltamethrin (DEL) inhibited Ca2+ sequestration by mitochondria and microsomes.
3(0,0,0,3) Details
8090688 Husain R, Malaviya M, Seth PK, Husain R: Effect of deltamethrin on regional brain polyamines and behaviour in young rats. Pharmacol Toxicol. 1994 Apr-May;74(4-5):211-5.

A significant increase in the activities of mitochondrial monoamine oxidase and microsomal acetylcholinesterase without any effect on microsomal Na+, K (+)-ATPase activity was observed in the brain of experimental animals.
1(0,0,0,1) Details
10993707 Calore EE, Cavaliere MJ, Puga FR, Calore NM, Rosa AR, Weg R, Dias SS, Santos RP: Histologic peripheral nerve changes in rats induced by deltamethrin. . Ecotoxicol Environ Saf. 2000 Sep;47(1):82-6.

Since these histologic changes are transitory and scarce, the question arises: Are they related to the changes in NA (+), K (+)-ATPase activity or Na (+) channels caused by pyrethroid compounds?
1(0,0,0,1) Details
3359951 Wang SJ, Zheng QL, Yu L, Xu BH, Li YR: Health survey among farmers exposed to deltamethrin in the cotton fields. Ecotoxicol Environ Saf. 1988 Feb;15(1):1-6.

0(0,0,0,0) Details