Protein Information

Name choline acetyltransferase
Synonyms CHAT; CHOACTase; CLAT; CMS1A; CMS1A2; ChAT; Choline O acetyltransferase; Choline acetylase…

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
10894124 Csillik B, Fazakas J, Nemcsok J, Knyihar-Csillik E: Effect of the pesticide Deltamethrin on the Mauthner cells of Lake Balaton fish. Neurotoxicology. 2000 Jun;21(3):343-52.

Even more importantly, however, Deltamethrin in a concentration of 10 micrograms per liter, induces blockade of the expression of choline acetyltransferase in the bulbous axon terminals synapsing with the lateral dendrites of the Mauthner cells.
81(1,1,1,1) Details
15936353 Hossain MM, Suzuki T, Sato I, Takewaki T, Suzuki K, Kobayashi H: Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain. Life Sci. 2005 Jul 1;77(7):795-807.

To better understand the mechanisms of their modulatory effects and also other effects on the cholinergic system in the brain, the activities of ACh hydrolyzing enzyme acetylcholinesterase (AChE), ACh synthesizing enzyme choline acetyltransferase (ChAT) and ACh synthesizing rate-limiting step, high-affinity choline uptake (HACU) were examined in the present study.
1(0,0,0,1) Details
19748499 Tayebati SK, Di Tullio MA, Ricci A, Amenta F: Influence of dermal exposure to the pyrethroid insecticide deltamethrin on rat brain microanatomy and cholinergic/dopaminergic neurochemistry. Brain Res. 2009 Dec 8;1301:180-8. Epub 2009 Sep 11.

Cholinergic neurotransmission markers investigated in frontal cortex, hippocampus and striatum were acetylcholine (ACh), the synthesizing and catabolic enzymes choline acetyltransferase and acetylcholinesterase and the high affinity ACh uptake system labeled with [(3) H] hemicholinium-3.
1(0,0,0,1) Details