| Name | glyceraldehyde 3 phosphate dehydrogenase |
|---|---|
| Synonyms | CDABP0047; G3PD; GAPD; GAPD protein; GAPDH; Glyceraldehyde 3 phosphate dehydrogenase; GAPD proteins; Glyceraldehyde 3 phosphate dehydrogenases |
| Name | α-chlorohydrin |
|---|---|
| CAS | 3-chloro-1,2-propanediol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16322075 | Nemeti B, Csanaky I, Gregus Z: Effect of an inactivator of glyceraldehyde-3-phosphate dehydrogenase, a fortuitous arsenate reductase, on disposition of arsenate in rats. Toxicol Sci. 2006 Mar;90(1):49-60. Epub 2005 Dec 1. |
7(0,0,0,7) | Details |
| 6887131 | Ford WC, Harrison A: The activity of glyceraldehyde 3-phosphate dehydrogenase in spermatozoa from different regions of the epididymis in laboratory rodents treated with alpha-chlorohydrin or 6-chloro-deoxyglucose. J Reprod Fertil. 1983 Sep;69(1):147-56. |
6(0,0,0,6) | Details |
| 19542219 | Frayne J, Taylor A, Cameron G, Hadfield AT: Structure of insoluble rat sperm glyceraldehyde-3-phosphate dehydrogenase (GAPDH) via heterotetramer formation with Escherichia coli GAPDH reveals target for contraceptive design. J Biol Chem. 2009 Aug 21;284(34):22703-12. Epub 2009 Jun 19. |
5(0,0,0,5) | Details |
| 4020765 | Stevenson D, Jones AR: Production of (S)-3-chlorolactaldehyde from (S)-alpha-chlorohydrin by boar spermatozoa and the inhibition of glyceraldehyde 3-phosphate dehydrogenase in vitro. J Reprod Fertil. 1985 May;74(1):157-65. |
3(0,0,0,3) | Details |
| 9702787 | Sheline CT, Choi DW: Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomerase. Neurobiol Dis. 1998 Jul;5(1):47-54. |
3(0,0,0,3) | Details |
| 6673906 | Ford SA, Jones AR: The effect of alpha-chlorohydrin on the oxidation of by rabbit spermatozoa in vitro. Contraception. 1983 Dec;28(6):565-73. At a concentration of 50 mM, (R,S)-alpha-chlorohydrin causes the specific inhibition of the enzyme glyceraldehyde 3-phosphate dehydrogenase and is metabolised by the spermatozoa to 3-chlorolactaldehyde of unknown configuration. |
2(0,0,0,2) | Details |
| 6776277 | Ford WC, Harrison A: Effect of alpha-chlorohydrin on metabolism by spermatozoa from the cauda epididymidis of the rhesus monkey (Macaca mulatta). J Reprod Fertil. 1980 Sep;60(1):59-64. It was concluded that the activity of glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) limited flux through the glycolytic pathway. |
2(0,0,0,2) | Details |
| 11012786 | Bone W, Cooper TG: In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, alpha-chlorohydrin and 1-chloro-3-hydroxypropanone. Int J Androl. 2000 Oct;23(5):284-93. The dose-dependent inhibition in vitro of the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and triosephosphate isomerase (TPI) of distal cauda epididymal rat spermatozoa by (R)-, (S)- and (R,S)-ornidazole (ORN), (R,S)-alpha-chlorohydrin (ACH) and 1-chloro-3-hydroxypropanone (CHOP) was compared. |
2(0,0,0,2) | Details |
| 11399799 | Jelks KB, Miller MG: alpha-Chlorohydrin inhibits glyceraldehyde-3-phosphate dehydrogenase in multiple organs as well as in sperm. Toxicol Sci. 2001 Jul;62(1):115-23. |
2(0,0,0,2) | Details |
| 729374 | Fitzpatrick RW, Jackson H, Dickinson NA: Effect of racemic and S (+) alpha-chlorohydrin-1- on glyceraldehyde-3-phosphate dehydrogenase in relation to its contraceptive action. Contraception. 1978 Nov;18(5):477-83. |
2(0,0,0,2) | Details |
| 629780 | Brown-Woodman PD, Mohri H, Mohri T, Suter D, White IG: Mode of action of alpha-chlorohydrin as a male anti-fertility agent. Biochem J. 1978 Jan 15;170(1):23-37. After incubation with 3mm-alpha-chlorohydrin, glyceraldehyde 3-phosphate dehydrogenase and triose phosphate isomerase activities were decreased by approx. 90% and 80% respectively, and in some experiments aldolase was also inhibited. |
2(0,0,0,2) | Details |
| 6861971 | Jones AR, Stevenson D: Formation of the active antifertility metabolite of (S)-alpha-chlorohydrin in boar sperm. Experientia. 1983 Jul 15;39(7):784-5. The presence of decreases the activity of this enzyme towards (S)-alpha-chlorohydrin in vitro thereby preventing the formation of (S)-3-chlorolactaldehyde, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase in boar sperm. |
1(0,0,0,1) | Details |
| 16407453 | Ford WC: Glycolysis and sperm motility: does a spoonful of sugar help the flagellum go round?. Hum Reprod Update. 2006 May-Jun;12(3):269-74. Epub 2006 Jan 11. An obligatory role for glycolysis is supported by the lack of progressive motility in sperm from mice where the gene for sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHs) had been 'knocked out'. |
1(0,0,0,1) | Details |
| 8848575 | Jones AR, Porter LM: Inhibition of glycolysis in boar spermatozoa by alpha-chlorohydrin appears to be mediated by phosphatase activity. Reprod Fertil Dev. 1995;7(5):1089-94. The high phosphatase activity hydrolyses the ester to alpha-chlorohydrin which undergoes oxidation to (S)-3-chlorolactaldehyde, a specific inhibitor of sperm glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase, thereby exhibiting an anti-glycolytic action. |
1(0,0,0,1) | Details |
| 21325689 | Terrell KA, Wildt DE, Anthony NM, Bavister BD, Leibo SP, Penfold LM, Marker LL, Crosier AE: Glycolytic enzyme activity is essential for domestic cat (Felis catus) and cheetah (Acinonyx jubatus) sperm motility and viability in a sugar-free medium. Biol Reprod. 2011 Jun;84(6):1198-206. Epub 2011 Feb 16. A second set of ejaculates was exposed to a chemical inhibitor of either lactate dehydrogenase oxamate) or glyceraldehyde-3-phosphate dehydrogenase (alpha-chlorohydrin). |
1(0,0,0,1) | Details |
| 11330647 | Bone W, Jones AR, Morin C, Nieschlag E, Cooper TG: Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro. J Androl. 2001 May-Jun;22(3):464-70. A dose-dependent inhibition of the glycolytic enzyme, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), of rat and mouse distal cauda epididymidal and human ejaculated sperm by ACH, CHOP, and DCDF was demonstrated. |
1(0,0,0,1) | Details |
| 20409345 | Xie S, Zhu Y, Ma L, Lu Y, Zhou J, Gui Y, Cao L: Genome-wide profiling of gene expression in the epididymis of alpha-chlorohydrin-induced infertile rats using an oligonucleotide microarray. Reprod Biol Endocrinol. 2010 Apr 22;8:37. BACKGROUND: As one of the chlorinated antifertility compounds, alpha-chlorohydrin (ACH) can inhibit glyceraldehyde-3-phosphate dehydrogenase (G3PDH) activity in epididymal sperm and affect sperm energy metabolism, maturation and fertilization, eventually leading to male infertility. |
1(0,0,0,1) | Details |
| 17321661 | Skamarauskas J, Carter W, Fowler M, Madjd A, Lister T, Mavroudis G, Ray DE: The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation. Toxicology. 2007 Apr 11;232(3):268-76. Epub 2007 Jan 21. The biochemical mechanism of toxicity of the experimental astrocyte neurotoxicant and food contaminant S-3-chloro- (3-CPD) has been proposed to be via inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). |
1(0,0,0,1) | Details |
| 6715067 | Stevenson D, Jones AR: The action of (R)- and (S)-alpha-chlorohydrin and their metabolites on the metabolism of boar sperm. Int J Androl. 1984 Feb;7(1):79-86. Its effect on the concentrations of glycolytic intermediates suggests that the pathway is inhibited at the glyceraldehyde 3-phosphate dehydrogenase reaction. alpha-Chlorohydrin is oxidized by boar liver homogenates via 3-chlorolactaldehyde to 3-chlorolactate. |
1(0,0,0,1) | Details |
| 483861 | Jones AR, Mashford PM, Murcott C: The metabolism of 3-amino-1-chloropropan-2-ol in relation to its antifertility activity in male rats. Xenobiotica. 1979 Apr;9(4):253-61. A difference in metabolic rate or route of the isomers may account for their differing physiological activities. 4. (+)- and (-)-aminochloropropanol exhibited identical in vitro inhibitory activities on the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase, and were substrates for monoamine oxidase to equivalent extents. |
1(0,0,0,1) | Details |
| 7277334 | Ford WC, Harrison A, Waites GM: Effects of 6-chloro-6-deoxysugars on oxidation in rat spermatozoa. . J Reprod Fertil. 1981 Sep;63(1):67-73. oxidation appeared to be inhibited at the triose phosphate isomerase or glyceraldehyde 3-phosphate dehydrogenase reaction. |
1(0,0,0,1) | Details |
| 3593119 | Jones AR, Bubb WA, Murdoch SR, Stevenson DA: Inhibition of fructolytic enzymes in boar spermatozoa by (S)-alpha-chlorohydrin and 1-chloro-3-hydroxypropanone. Aust J Biol Sci. 1986;39(4):395-406. When boar spermatozoa were incubated with the (S)-isomer of the male antifertility agent alpha-chlorohydrin the activity of glyceraldehyde-3-phosphate dehydrogenase was inhibited. |
1(0,0,0,1) | Details |
| 7471740 | Hutton P, Dawson AG, Jones AR: Inhibition of glycolysis in boar sperm by alpha-chlorohydrin. Contraception. 1980 Nov;22(5):505-12. Low levels of alpha-chlorohydrin increased the cellular concentrations of and the triosephosphates, an effect consistent with the inhibition of glyceraldehyde-3-phosphate dehydrogenase. |
1(0,0,0,1) | Details |
| 563260 | Dickinson NA, Fitzpatrick RW, Jackson H: Antifertility mode of action of alpha-chlorohydrin--interaction with glyceraldehyde-3-phosphate-dehydrogenase [proceedings]. Br J Pharmacol. 1977 Nov;61(3):456P. |
1(0,0,0,1) | Details |
| 3339589 | Cooney SJ, Jones AR: Inhibitory effects of (S)-3-chlorolactaldehyde on the metabolic activity of boar spermatozoa in vitro. J Reprod Fertil. 1988 Jan;82(1):309-17. (S)-alpha-Chlorohydrin and 3-chloro-1-hydroxyacetone inhibited the oxidative metabolism of by boar spermatozoa only after a period of incubation in which they presumably underwent conversion to (S)-3-chlorolactaldehyde, an inhibitor of sperm glyceraldehyde 3-phosphate dehydrogenase. |
1(0,0,0,1) | Details |