| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | α-chlorohydrin |
|---|---|
| CAS | 3-chloro-1,2-propanediol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11709044 | Bull S, Langezaal I, Clothier R, Coecke S: A Genetically engineered cell-based system for detecting metabolism-mediated toxicity. Altern Lab Anim. 2001 Nov-Dec;29(6):703-16. Xenobiotics undergoing bioactivation by CYP450 enzymes form reactive metabolites that may exert direct metabolism-mediated toxicity. |
5(0,0,0,5) | Details |
| 11317702 | Bloemen LJ, Monster AC, Kezic S, Commandeur JN, Veulemans H, Vermeulen NP, Wilmer JW: Study on the cytochrome P-450- and -dependent biotransformation of trichloroethylene in humans. Int Arch Occup Environ Health. 2001 Mar;74(2):102-8. |
2(0,0,0,2) | Details |
| 8825194 | Ni YC, Wong TY, Lloyd RV, Heinze TM, Shelton S, Casciano D, Kadlubar FF, Fu PP: Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism. Drug Metab Dispos. 1996 Jan;24(1):81-90. In addition, CH-induced lipid peroxidation catalyzed by control-microsomes and pyrazole-microsomes was reduced significantly by 2,4-dichloro-6-phenylphenoxyethylamine, a general cytochrome P450 inhibitor. |
2(0,0,0,2) | Details |
| 8104122 | Loizou GD, Anders MW: Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluoroethane (HCFC-141b). Drug Metab Dispos. 1993 Jul-Aug;21(4):634-9. Diallyl sulfide, a selective, mechanism-based inhibitor of cytochrome P-450 2E1, inhibited the metabolism of HCFC-141b, as indicated by a decreased uptake of HCFC-141b and by a lowered urinary excretion of 2,2-dichloro-2-fluoroethanol in diallyl-sulfide-treated rats. |
2(0,0,0,2) | Details |
| 11730869 | Shang TQ, Doty SL, Wilson AM, Howald WN, Gordon MP: Trichloroethylene oxidative metabolism in plants: the trichloroethanol pathway. Phytochemistry. 2001 Dec;58(7):1055-65. It was previously shown that TCE metabolites in plants are similar to ones that result from cytochrome P450-mediated oxidation in mammals: trichloroethanol, trichloroacetate and dichloroacetate. |
1(0,0,0,1) | Details |
| 8825189 | Birner G, Rutkowska A, Dekant W: N-acetyl-S-(1,2,2-trichlorovinyl)- and 2,2,2-trichloroethanol: two novel metabolites of tetrachloroethene in humans after occupational exposure. Drug Metab Dispos. 1996 Jan;24(1):41-8. The excretion of tetrachloroethene metabolites in urine was studied in occupationally exposed workers to identify and quantify metabolites formed by conjugation and by cytochrome P450 oxidation of tetrachloroethene in humans. |
1(0,0,0,1) | Details |
| 17697698 | Marco-Urrea E, Parella T, Gabarrell X, Caminal G, Vicent T, Adinarayana Reddy C: Mechanistics of trichloroethylene mineralization by the white-rot fungus Trametes versicolor. Chemosphere. 2008 Jan;70(3):404-10. Epub 2007 Aug 13. Cytochrome P-450 appears to be involved in TCE degradation, as evidenced by marked inhibition of degradation of TCE in the presence of 1-aminobenzotriazole, a known inhibitor of cytochrome P-450. |
1(0,0,0,1) | Details |
| 2593173 | Larson JL, Bull RJ: Effect of on the metabolism of trichloroethylene. J Toxicol Environ Health. 1989;28(4):395-406. Trichloroethylene (TCE) is metabolized to chloral hydrate (CH) by the cytochrome P-450 monooxygenase system. |
1(0,0,0,1) | Details |
| 9192205 | Stott I, Murthy A, Robinson A, Thomas NW, Fry JR: Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1,3-dichloro- and selectively inhibits CYP2E1 activity in the rat. Hum Exp Toxicol. 1997 May;16(5):262-6. The effect of low doses of diethyldithiocarbamate (DEDC) on hepatic cytochrome P450-dependent enzyme activity and 1,3-dichloro- (DCP) hepatotoxicity in the rat have been investigated. |
1(0,0,0,1) | Details |
| 21718811 | Xiao P, Mori T, Kondo R: Biotransformation of the organochlorine pesticide trans-chlordane by wood-rot fungi. N Biotechnol. 2011 Jun 28. Additionally, transformation of trans-chlordane and production of hydroxylated metabolites were efficiently inhibited by the addition of cytochrome P450 inhibitors, piperonyl butoxide and 1-aminobenzotriazole, demonstrating that fungal cytochrome P450 enzymes are involved in some steps of trans-chlordane metabolism, particularly in the hydroxylation process. |
1(0,0,0,1) | Details |
| 9434844 | Frei H, Wurgler FE: The vicinal chloroalcohols 1,3-dichloro- (DC2P), 3-chloro- (3CPD) and 2-chloro-1,3- (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster. Mutat Res. 1997 Nov 27;394(1-3):59-68. The test was applied here in its standard version with normal bioactivation and in a variant with increased cytochrome P450-dependent bioactivation capacity. |
1(0,0,0,1) | Details |
| 11201665 | De Smet K, Bruning T, Blaszkewicz M, Bolt HM, Vercruysse A, Rogiers V: Biotransformation of trichloroethylene in collagen gel sandwich cultures of rat hepatocytes. Arch Toxicol. 2000 Dec;74(10):587-92. Endpoints studied were albumin secretion and the cytochrome P450 (CYP)-dependent enzymatic activities ethoxyresorufin O-deethylase (EROD), pentoxyresorufin O-depentylase (PROD) and N-nitrosodimethylamine demethylase (NDMA). |
1(0,0,0,1) | Details |