Protein Information

Name NMDA receptor (protein family or complex)
Synonyms Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors

Compound Information

Name α-chlorohydrin
CAS 3-chloro-1,2-propanediol

Reference List

PubMed Abstract RScore(About this table)
19788495 Salous AK, Ren H, Lamb KA, Hu XQ, Lipsky RH, Peoples RW: Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit. Br J Pharmacol. 2009 Nov;158(5):1395-404. Epub 2009 Sep 25.

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10082216 Scheibler P, Kronfeld A, Illes P, Allgaier C: Trichloroethanol impairs NMDA receptor function in rat mesencephalic and cortical neurones. Eur J Pharmacol. 1999 Feb 5;366(2-3):R1-2.

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15223373 Criswell HE, Ming Z, Pleasant N, Griffith BL, Mueller RA, Breese GR: Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethers. Brain Res. 2004 Jul 23;1015(1-2):107-13.


Volatile hydrocarbon based CNS depressants including short chain alcohols and anesthetics act, in part, by inhibition of the excitatory effect of glutamate at the NMDA receptor.
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