Protein Information

Name lipase
Synonyms HGL; HPL; HGL; Human giant larvae homolog; LGL 2; LGL2; LLGL 2; LLGL2…

Compound Information

Name α-chlorohydrin
CAS 3-chloro-1,2-propanediol

Reference List

PubMed Abstract RScore(About this table)
15291482 Robert MC, Oberson JM, Stadler RH: Model studies on the formation of monochloropropanediols in the presence of lipase. J Agric Food Chem. 2004 Aug 11;52(16):5102-8.

4(0,0,0,4) Details
15357996 Kamal A, Sandbhor M, Ali Shaik A: Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4581-3.

3(0,0,0,3) Details
18817401 Traff A, Bogar K, Warner M, Backvall JE: Highly efficient route for enantioselective preparation of chlorohydrins via dynamic kinetic resolution. Org Lett. 2008 Nov 6;10(21):4807-10. Epub 2008 Sep 26.


Dynamic kinetic resolution (DKR) of various aromatic chlorohydrins with the use of Pseudomonas cepacia lipase (PS-C "Amano" II) and ruthenium catalyst 1 afforded chlorohydrin acetates in high yields and high enantiomeric excesses.
1(0,0,0,1) Details
6134687 Gill SK, Guraya SS: Effects of low doses of alpha chlorohydrin on the lipid metabolism of the rat testis and epididymis--a correlative histochemical and biochemical study. Int J Fertil. 1983;28(1):43-8.


The altered levels of lipid fractions were due to the increased activity of glycerol phosphate dehydrogenase and to the decreased activities of nonspecific esterase and lipase after treatment with the drug.
1(0,0,0,1) Details