| Name | manganese superoxide dismutases |
|---|---|
| Synonyms | IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD… |
| Name | sodium cyanide |
|---|---|
| CAS | sodium cyanide (Na(CN)) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18069076 | Bavis RW, Wenninger JM, Miller BM, Dmitrieff EF, Olson EB Jr, Mitchell GS, Bisgard GE: Respiratory plasticity after perinatal hyperoxia is not prevented by antioxidant supplementation. Respir Physiol Neurobiol. 2008 Feb 29;160(3):301-12. Epub 2007 Oct 30. Rats were born and raised in 60% O (2) for the first two postnatal weeks while treated with one of two antioxidants: (via milk from mothers whose diet was enriched with 1000 IU kg (-1)) or a superoxide dismutase mimetic, (III) tetrakis (1-methyl-4-pyridyl) pentachloride (MnTMPyP; via daily intraperitoneal injection of 5-10 mg kg (-1)); rats were subsequently raised in room air until studied as adults. |
1(0,0,0,1) | Details |
| 17307400 | Indo HP, Davidson M, Yen HC, Suenaga S, Tomita K, Nishii T, Higuchi M, Koga Y, Ozawa T, Majima HJ: Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion. 2007 Feb-Apr;7(1-2):106-18. Epub 2006 Dec 13. Furthermore, manganese superoxide dismutase (MnSOD) cDNA-transfected cells had decreased ROS. ETC inhibitors (rotenone, 3-nitropropionic acid, thenoyltrifluoroacetone, antimycin A and sodium cyanide) were also tested to determine whether inhibitor treatment increased intracellular reactive species (ROS) generation. |
1(0,0,0,1) | Details |
| 2822303 | Geffner JR, Giordano M, Palermo MS, Prat A, Serebrinsky GP, Isturiz MA: Neutrophil-mediated cytotoxicity triggered by immune complexes: the role of reactive metabolites. Clin Exp Immunol. 1987 Sep;69(3):668-75. Superoxide dismutase (SOD) and certain HO. and 1O2 scavengers were unable to exert significant effects. Three haem-enzyme inhibitors, azide, sodium cyanide and 3-amino-1,2,4-triazole did not decrease neutrophil NSC, but markedly enhanced it. |
1(0,0,0,1) | Details |
| 16630587 | Zemlyak I, Nimon V, Brooke S, Moore T, McLaughlin J, Sapolsky R: Gene therapy in the nervous system with superoxide dismutase. . Brain Res. 2006 May 9;1088(1):12-8. Epub 2006 Apr 21. We investigated the effects of antioxidant gene therapy on ROS accumulation after exposure to either sodium cyanide, kainic acid or oxygen glucose deprivation (OGD). |
1(0,0,0,1) | Details |
| 9748253 | Xia Y, Tsai AL, Berka V, Zweier JL: generation from endothelial nitric-oxide synthase. J Biol Chem. 1998 Oct 2;273(40):25804-8. With the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), prominent signals of O-2 adduct, DMPO-OOH, were detected from eNOS in the absence of added (BH4), and these were quenched by superoxide dismutase. |
1(0,0,0,1) | Details |
| 11717389 | Helmerhorst EJ, Troxler RF, Oppenheim FG: The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive species. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14637-42. Epub 2001 Nov 20. In contrast to histatin 5, the conventional inhibitors of the respiratory chain, sodium cyanide or azide, neither induced ROS nor killed yeast cells. In addition, the membrane-permeant superoxide dismutase mimetic 2,2,6,6-tetramethylpiperidine-N-oxyl, abolished histatin-induced ROS formation in isolated mitochondria. |
1(0,0,0,1) | Details |
| 18419797 | Sasaki T, Unno K, Tahara S, Shimada A, Chiba Y, Hoshino M, Kaneko T: Age-related increase of generation in the brains of mammals and birds. Aging Cell. 2008 Aug;7(4):459-69. Epub 2008 Apr 14. The activity of superoxide dismutase was unchanged during the aging process in the brain. |
1(0,0,0,1) | Details |
| 11934248 | Wang HT, Yang XL, Zhang ZH, Lu JL, Xu HB: Reactive species from mitochondria mediate SW480 cells apoptosis induced by Na2SeO3. Biol Trace Elem Res. 2002 Mar;85(3):241-54. The intracellular ROS increase and apoptosis induced by Na2SeO3 were significantly decreased by superoxide dismutase (SOD), catalase. |
1(0,0,0,1) | Details |
| 2162328 | Geffner JR, Minnucci F, Isturiz MA: Neutrophil-mediated cytotoxicity induced by secretory IgA. Immunol Lett. 1990 May;24(2):113-6. Catalase completely impaired this non-specific cytotoxicity (NSC), while superoxide dismutase (SOD) significantly enhanced it, suggesting a key role for peroxide (H2O2) in the lysis of target cells. Three heme-enzyme inhibitors, azide, sodium cyanide and 3-amino-1,2,4-triazole, did not decrease NSC, but significantly enhanced it, suggesting that the mechanism involved is not dependent upon myeloperoxidase (MPO). |
1(0,0,0,1) | Details |
| 11401469 | Allegra M, Furtmuller PG, Regelsberger G, Turco-Liveri ML, Tesoriere L, Perretti M, Livrea MA, Obinger C: Mechanism of reaction of with human myeloperoxidase. . Biochem Biophys Res Commun. 2001 Mar 30;282(2):380-6. Steady-state experiments showed that the rate of oxidation of is dependent on the H (2) O (2) concentration, is not affected by superoxide dismutase, and is quickly terminated by sodium cyanide. |
0(0,0,0,0) | Details |
| 7141693 | Diamond RD, Haudenschild CC, Erickson NF 3rd: Monocyte-mediated damage to Rhizopus oryzae hyphae in vitro. Infect Immun. 1982 Oct;38(1):292-7. As with neutrophils, monocyte-mediated damage of R. oryzae was significantly decreased by some inhibitors of oxidative metabolism and scavengers of the potentially microbicidal oxidative leukocyte products, which included 10 (-4) M azide, 10 (-3) M sodium cyanide, catalase, 10 (-3) M 10 (-3) M and 10 (-4) M 1,4-diazobicyclo [2.2.2] but not superoxide dismutase, 1.4 X 10 (-2) M and 4.0 X 10 (-1) M |
0(0,0,0,0) | Details |
| 10775326 | Regal KA, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF: Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry. Chem Res Toxicol. 2000 Apr;13(4):262-70. No protection from inactivation was seen in the presence of nucleophiles and sodium cyanide), an iron chelator (deferroxamine), or superoxide dismutase and catalase. |
0(0,0,0,0) | Details |
| 340471 | Daimond RD, Krzesicki R: Mechanisms of attachment of neutrophils to Candida albicans pseudohyphae in the absence of serum, and of subsequent damage to pseudohyphae by microbicidal processes of neutrophils in vitro. J Clin Invest. 1978 Feb;61(2):360-9. Damage to Candida by neutrophils was inhibited by agents known to act on neutrophil oxidative microbicidal mechanisms, including sodium cyanide, azide, catalase, superoxide dismutase, and 1, 4 diazobicyclo (2, 2, 2) a singlet quencher. |
31(0,1,1,1) | Details |
| 8392491 | Ginsburg I, Misgav R, Gibbs DF, Varani J, Kohen R: Chemiluminescence in activated human neutrophils: role of buffers and scavengers. Inflammation. 1993 Jun;17(3):227-43. CL and LDCL of activated PMNs was enhanced by aminotriazole, but strongly inhibited by diphenylene iodonium (an inhibitor of oxidase) by azide, sodium cyanide (CN), cimetidine, DMTU and moderately by superoxide dismutase (SOD) and by deferoxamine LUCDCL was markedly inhibited only by SOD but was boosted by CN. |
31(0,1,1,1) | Details |
| 1656946 | Bynoe LA, Pou S, Gottsch JD, Rosen GM: Light-dependent spin trapping of from human erythrocytes. . Biochem Biophys Res Commun. 1991 Sep 30;179(3):1305-10. By inhibiting erythrocyte superoxide dismutase, catalase, and peroxidase with N,N-diethyldithiocarbamate or sodium cyanide, we demonstrate the light-dependent generation of in human erythrocytes using spin trapping/Electron Spin Resonance spectroscopy. |
31(0,1,1,1) | Details |
| 8042972 | Dey R, Datta SC: Leishmanial glycosomes contain superoxide dismutase. . Biochem J. 1994 Jul 15;301 ( Pt 2):317-9. |
4(0,0,0,4) | Details |
| 9509413 | An SS, Kim YM: Purification and characterization of a manganese-containing superoxide dismutase from a carboxydobacterium, Pseudomonas carboxydohydrogena. Mol Cells. 1997 Dec 31;7(6):730-7. azide, but not sodium cyanide and peroxide, was found to inhibit the enzyme activity. |
3(0,0,0,3) | Details |
| 17646712 | Seo SN, Lee JH, Kim YM: Characterization of an iron- and manganese-containing superoxide dismutase from Methylobacillus sp. strain SK1 DSM 8269. Mol Cells. 2007 Jun 30;23(3):370-8. peroxide and azide, but not sodium cyanide, was found to inhibit the purified enzyme. |
3(0,0,0,3) | Details |
| 11997380 | Samis K, Bowley S, McKersie B: Pyramiding Mn-superoxide dismutase transgenes to improve persistence and biomass production in alfalfa. J Exp Bot. 2002 May;53(372):1343-50. |
2(0,0,0,2) | Details |
| 9353077 | Whitehouse CA, Williams LR, Austin FE: Identification of superoxide dismutase activity in Borrelia burgdorferi. Infect Immun. 1997 Nov;65(11):4865-8. |
2(0,0,0,2) | Details |
| 3408810 | Mukherjee S, Bandyapadhyay R, Basu MK: Leishmania donovani: superoxide dismutase level in infected macrophages. . Biosci Rep. 1988 Apr;8(2):131-7. |
2(0,0,0,2) | Details |
| 3104309 | May BP, Dennis PP: Superoxide dismutase from the extremely halophilic archaebacterium Halobacterium cutirubrum. J Bacteriol. 1987 Apr;169(4):1417-22. |
2(0,0,0,2) | Details |
| 16169521 | Xu KY, Kuppusamy P: Dual effects of -zinc superoxide dismutase. . Biochem Biophys Res Commun. 2005 Nov 4;336(4):1190-3. Sodium cyanide, and N,N'-diethyldithiocarbamate abolished (.) OH generation, implying that Cu may be responsible for dCuZnSOD-induced (.) OH formation. |
2(0,0,0,2) | Details |
| 8837454 | Dowjat WK, Kharatishvili M, Costa M: DNA and RNA strand scission by zinc and manganese superoxide dismutases. Biometals. 1996 Oct;9(4):327-35. Another mechanism was probably operative in this system, since in the presence of DNA cleavage by SOD was independent and not affected by sodium cyanide. |
2(0,0,0,2) | Details |
| 3028255 | Mashino T, Fridovich I: Mechanism of the -catalyzed oxidation of alpha-ketoaldehydes and alpha-ketoalcohols. Arch Biochem Biophys. 1987 Jan;252(1):163-70. The inhibitory effect of the manganese-containing superoxide dismutase indicated that O2- was a kinetically important intermediate of the rapid phase reaction. |
1(0,0,0,1) | Details |
| 12531891 | Zhang Y, Han H, Wang J, Wang H, Yang B, Wang Z: Impairment of human ether-a-go-go-related gene (HERG) K+ channel function by hypoglycemia and hyperglycemia. J Biol Chem. 2003 Mar 21;278(12):10417-26. Epub 2003 Jan 16. Inhibition of oxidative phosphorylation by NaCN or application of antioxidants or superoxide dismutase mimetic (Mn (III) tetrakis (4- abrogated and incubation with /xanthine oxidase mimicked the effects of hyperglycemia. |
1(0,0,0,1) | Details |
| 10489115 | Matsuki N, Takanohashi A, Boffi FM, Inanami O, Kuwabara M, Ono K: generation and lipid peroxidation in C2C12 myotube treated with iodoacetate and Free Radic Res. 1999 Jul;31(1):1-8. To mimic exercise-induced events such as energetic impairment, free radical generation, and lipid peroxidation in vitro, mouse-derived C2C12 myotubes were submitted to the inhibition of glycolytic and/or oxidative metabolism with 1 mM iodoacetate (IAA) and/or 2 mM sodium cyanide (CN), respectively, under 5% CO2/95% air up to 180 min. By the addition of iron-chelating 1 mM deferoxamine to the C2C12 preparation with IAA + CN, both ESR signals of DMPO-OH and DMPO-R were completely abolished, and the release of MDA and LDH were significantly reduced, while -resistant manganese superoxide dismutase had negligible effects on these parameters. |
1(0,0,0,1) | Details |
| 11287127 | Porasuphatana S, Tsai P, Pou S, Rosen GM: Involvement of the perferryl complex of synthase in the catalysis of secondary free radical formation. Biochim Biophys Acta. 2001 Apr 3;1526(1):95-104. Superoxide dismutase prevented CH (3)*CHOH formation in the absence of Formation of CH (3)*CHOH was inhibited by substituting for or inclusion of the NOS inhibitors N (G)-nitro- methyl ester, N (G)-monomethyl- and the heme blocker, sodium cyanide. |
1(0,0,0,1) | Details |
| 10222047 | Longo VD, Liou LL, Valentine JS, Gralla EB: Mitochondrial decreases yeast survival in stationary phase. Arch Biochem Biophys. 1999 May 1;365(1):131-42. Yeast lacking mitochondrial superoxide dismutase (MnSOD) display shortened stationary-phase survival and provide a good model system for studying mitochondrial oxidative damage. |
1(0,0,0,1) | Details |