Protein Information

Name caspase (protein family or complex)
Synonyms caspase; caspases

Compound Information

Name sodium cyanide
CAS sodium cyanide (Na(CN))

Reference List

PubMed Abstract RScore(About this table)
14730895 Zhang JJ, Shi RL: [Effects of caspases on cerebromicrovascular endothelial cell apoptosis induced by hypoxia]. Yao Xue Xue Bao. 2003 Oct;38(10):739-42.

5(0,0,0,5) Details
16697116 Niquet J, Seo DW, Allen SG, Wasterlain CG: Hypoxia in presence of blockers of excitotoxicity induces a caspase-dependent neuronal necrosis. Neuroscience. 2006 Aug 11;141(1):77-86. Epub 2006 May 11.

2(0,0,0,2) Details
16749863 Souid AK, Penefsky HS, Sadowitz PD, Toms B: Enhanced cellular respiration in cells exposed to doxorubicin. . Mol Pharm. 2006 May-Jun;3(3):307-21.

The increment in oxygen consumption was blocked by the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-dl-Asp-fluoromethylketone (zVAD-fmk) and by the PTP inhibitor cyclosporin A.
The conclusion that both of the latter processes were products of oxidations in the mitochondrial respiratory chain was supported by the further observation that rotenone and sodium cyanide inhibited oxygen consumption and substantially lowered ATP content in the treated and untreated cells.
1(0,0,0,1) Details
12176748 Li F, Mao HP, Ruchalski KL, Wang YH, Choy W, Schwartz JH, Borkan SC: Heat stress prevents mitochondrial injury in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol. 2002 Sep;283(3):C917-26.

By reducing outer mitochondrial membrane injury and by complexing with cytochrome c, hsp72 could inhibit caspase activation and subsequent apoptosis.
To test these hypotheses, renal epithelial cells were transiently ATP depleted with sodium cyanide and 2-deoxy-D-glucose in the absence of medium dextrose.
1(0,0,0,1) Details