| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | sodium cyanide |
|---|---|
| CAS | sodium cyanide (Na(CN)) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2900731 | Shigenaga MK, Trevor AJ, Castagnoli N Jr: Metabolism-dependent covalent binding of (S)-[5-3H] to liver and lung microsomal macromolecules. Drug Metab Dispos. 1988 May-Jun;16(3):397-402. Sodium cyanide, which forms stable adducts with the cytochrome P-450-generated iminium ion metabolites of (S)- and a variety of other tertiary amines, inhibited covalent binding but also decreased the rate of (S)- metabolism. |
31(0,1,1,1) | Details |
| 6208195 | Trzaskos JM, Bowen WD, Shafiee A, Fischer RT, Gaylor JL: Cytochrome P-450-dependent oxidation of in cholesterol biosynthesis. J Biol Chem. 1984 Nov 10;259(21):13402-12. |
5(0,0,0,5) | Details |
| 9518732 | Xiao YF, Huang L, Morgan JP: Cytochrome P450: a novel system modulating Ca2+ channels and contraction in mammalian heart cells. J Physiol. 1998 May 1;508 ( Pt 3):777-92. |
3(0,0,0,3) | Details |
| 12595299 | Ju YK, Allen DG: Early effects of metabolic inhibition on intracellular Ca2+ in toad pacemaker cells: involvement of Ca2+ stores. Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1087-94. Epub 2002 Dec 5. It has been proposed that CN (-) acts by inhibition of cytochrome P-450, resulting in a reduction of cAMP and Ca (2+) current. |
2(0,0,0,2) | Details |
| 1680654 | Masumoto H, Ohta S, Hirobe M: Application of chemical cytochrome P-450 model systems to studies on drug metabolism. Drug Metab Dispos. 1991 Jul-Aug;19(4):768-80. |
2(0,0,0,2) | Details |
| 11465044 | Vickers S, Polsky SL: The biotransformation of containing xenobiotics to lactams. Curr Drug Metab. 2000 Dec;1(4):357-89. If the latter is stable it may undergo oxidation by cytochrome P-450 to form the lactam. When microsomal preparations are incubated with the appropriate substrate in the presence of sodium cyanide the iminium ion may be trapped to produce a cyano compound. |
2(0,0,0,2) | Details |
| 3556837 | Freeman JJ, Hayes EP: The metabolism of acetonitrile to by isolated rat hepatocytes. . Fundam Appl Toxicol. 1987 Feb;8(2):263-71. The metabolism of saturated nitriles, including acetonitrile, has been assumed to occur by a cytochrome P-450-dependent oxidation at the alpha-carbon, yielding a cyanohydrin intermediate which may spontaneously degrade to and an heme did not affect the recovery of sodium cyanide from hepatocyte suspensions. |
2(0,0,0,2) | Details |
| 9635141 | Shumyantseva VV, Avdeenko YL, Moskvitina TL, Bulko TV, Archakov AI: peroxide-supported activities of semisynthetic flavocytochrome 2B4. Biochem Mol Biol Int. 1998 Jun;45(1):171-9. The rates of the flavocytochrome-catalyzed, H2O2-supported reactions far exceeded those of the appropriate -dependent reactions and were comparable with the cytochrome P450 2B4-catalyzed, peroxide-mediated reaction rates. Sodium cyanide and SKF-525A, a specific P450 inhibitor, were both shown to inhibit these reactions. |
1(0,0,0,1) | Details |
| 10920253 | Imai Y, Matsunaga I, Kusunose E, Ichihara K: Unique heme environment at the putative distal region of peroxide-dependent fatty acid alpha-hydroxylase from Sphingomonas paucimobilis (peroxygenase P450 (SPalpha). J Biochem. 2000 Aug;128(2):189-94. Fatty acid alpha-hydroxylase from Sphingomonas paucimobilis is a peroxide-dependent cytochrome P450 (P450) enzyme (P450 (SPalpha)). |
1(0,0,0,1) | Details |
| 19278021 | Song C, Scharf ME: Mitochondrial impacts of insecticidal esters in insecticide-resistant and insecticide-susceptible Drosophila melanogaster. Pest Manag Sci. 2009 Jun;65(6):697-703. These studies compared two Drosophila strains: an insecticide-susceptible strain (Canton-S) and a strain resistant by cytochrome P450 overexpression (Hikone-R). RESULTS: In initial studies investigating inhibition of mitochondrial cytochrome c oxidase, two proven insecticidal materials (hydramethylnon and sodium cyanide) caused significant inhibition. |
1(0,0,0,1) | Details |
| 10985797 | Wengenack NL, Lopes H, Kennedy MJ, Tavares P, Pereira AS, Moura I, Moura JJ, Rusnak F: Redox potential measurements of the Mycobacterium tuberculosis heme protein KatG and the isoniazid-resistant enzyme KatG (S315T): insights into isoniazid activation. Biochemistry. 2000 Sep 19;39(37):11508-13. Isoniazid activation may proceed via a cytochrome P450-like mechanism. |
1(0,0,0,1) | Details |
| 6313164 | Senciall IR, Bullock G, Rahal S: C21 hydroxylation and steroid carboxylic acid biosynthesis in the rabbit. Can J Biochem Cell Biol. 1983 Jul;61(7):722-30. Sodium cyanide had a stimulatory effect on the synthesis of pregnenoic acid by the liver but less consistent effects with other tissues. These results suggest that one or more cytochrome P-450 systems may be involved in the oxidation of through to pregnenoic acid by rabbit tissues. |
1(0,0,0,1) | Details |
| 10775326 | Regal KA, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF: Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry. Chem Res Toxicol. 2000 Apr;13(4):262-70. No protection from inactivation was seen in the presence of nucleophiles and sodium cyanide), an iron chelator (deferroxamine), or superoxide dismutase and catalase. |
1(0,0,0,1) | Details |
| 2775309 | Lambert C, Park BK, Kitteringham NR: Activation of mianserin and its metabolites by human liver microsomes. . Biochem Pharmacol. 1989 Sep 1;38(17):2853-8. Inhibition of irreversible binding was demonstrated with sodium cyanide at concentrations which did not inhibit total metabolism, which suggest that metabolic activation by the cytochrome P-450 enzyme system may lead to the formation of a reactive iminium intermediate that can bind to nucleophilic groups on proteins. |
0(0,0,0,0) | Details |
| 3874963 | Weissman J, Trevor A, Chiba K, Peterson LA, Caldera P, Castagnoli N Jr, Baillie T: Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractions. J Med Chem. 1985 Aug;28(8):997-1001. Attempts to trap possible unstable iminium metabolites of MPTP in microsomal incubation mixtures with sodium cyanide led to the isolation of a monocyano adduct that proved to be the N-cyanomethyl derivative. |
0(0,0,0,0) | Details |