| Name | choline acetyltransferase |
|---|---|
| Synonyms | CHAT; CHOACTase; CLAT; CMS1A; CMS1A2; ChAT; Choline O acetyltransferase; Choline acetylase… |
| Name | sodium cyanide |
|---|---|
| CAS | sodium cyanide (Na(CN)) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 4982085 | Fonnum F: Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. Biochem J. 1969 Nov;115(3):465-72. The values of choline acetyltransferase activity obtained in the presence of sodium cyanide or EDTA and synthetic were similar to those obtained with synthesized in situ. 6. |
34(0,1,1,4) | Details |
| 2853945 | Sher PK: -induced chronic partial asphyxia in vitro: neurochemical abnormalities and reversal by Pediatr Neurol. 1987 Jul-Aug;3(4):197-202. Neuronal cortical cell cultures obtained from fetal mice were subjected to increasing concentrations of sodium cyanide (10-500 microM) for 6 days in order to simulate prolonged partial asphyxia. Choline acetyltransferase activity was reduced significantly from control values at concentrations greater than 100 microM; there were similar reductions on a percentage basis in high-affinity uptake of and and in clonazepam-displaceable benzodiazepine (BDZ) binding which reflected the neuronal BDZ receptor population. |
1(0,0,0,1) | Details |
| 870085 | Lefresne P, Hamon M, Beaujouan JC, Glowinski J: Origin of the acetyl moiety of synthesized in rat striatal synaptosomes. Biochimie. 1977;59(2):197-215. The subcellular localization of the AcCoA compartment supplying the cytoplasmic choline acetyltransferase (ChAc, EC 2.3.1.6) was investigated using a purified preparation of rat striatal synaptosomes (B fraction). The experimental value obtained from a 10 min incubation, after the nerve endings had reached a steady metabolic activity, indicate that if the acetyl moiety of was derived from some Krebs cycle intermediary compounds, its SRA could never exceed 55 per cent that of the [2-14C] from which it is produced, (iv) No correlation could be found between the rate of [14C] formation and changes in the Krebs cycle activity induced by sodium cyanide, 2-4 dinitrophenol and Ca2+ free medium. (v) The lack of significant [14C] synthesis from [1-14C] in striatal synaptosomes is consistent with the failure of fluoroacetate to modify the amounts of 14CO2 as well as of [14C] formed from [2-14C] |
1(0,0,0,1) | Details |
| 15645293 | Mastrodimou N, Lambrou GN, Thermos K: Effect of somatostatin analogues on chemically induced ischaemia in the rat retina. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jan;371(1):44-53. Epub 2005 Jan 12. Eyecups of female Sprague-Dawley rats (250-300 g) were immersed in PBS buffer or PBS containing iodoacetic acid (IAA; 0.5, 5, 50, 100 mM) and sodium cyanide (NaCN; 2.5, 25, 250, 500 mM) (chemical ischaemia solution) for 15, 30, 45, 60, 120 min (pilot study). Treatment of the eyecups with IAA/NaCN (5/25 mM) for 60 min abolished choline acetyltransferase (ChAT), tyrosine hydroxylase and brain synthase immunoreactivity in the inner nuclear, inner plexiform and ganglion cell layers. |
2(0,0,0,2) | Details |
| 2834659 | Sher PK: Neurochemical correlates of -induced hypoxic neuronal damage in vitro. Neurochem Res. 1988 Feb;13(2):159-63. Neuronal cortical cell cultures obtained from fetal mice were subjected to an hypoxic insult produced by sodium cyanide (1 mM) for 24 h. However, specific and clonazepam-displaceable BDZ binding (81 +/- 4% and 50 +/- 9% of control values, respectively), high-affinity [3H] uptake (75 +/- 2%), and choline acetyltransferase activity (82 +/- 2%) were significantly lower. |
1(0,0,0,1) | Details |