Protein Information

Name serum cholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name azinphos-methyl
CAS

Reference List

PubMed Abstract RScore(About this table)
18533225 Kristoff G, Verrengia Guerrero NR, Cochon AC: Effects of azinphos-methyl exposure on enzymatic and non-enzymatic antioxidant defenses in Biomphalaria glabrata and Lumbriculus variegatus. Chemosphere. 2008 Jul;72(9):1333-9. Epub 2008 Jun 3.

Recently, it has been shown that L. variegatus worms exhibit a higher cholinesterase (ChE) activity and a greater sensitivity to in vivo ChE inhibition by azinphos-methyl than pigmented B. glabrata snails.
118(1,2,3,3) Details
16597480 Kristoff G, Guerrero NV, de D'Angelo AM, Cochon AC: Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus. Toxicology. 2006 May 15;222(3):185-94. Epub 2006 Apr 4.
113(1,2,2,3) Details
9891917 Astroff AB, Young AD: The relationship between maternal and fetal effects following maternal organophosphate exposure during gestation in the rat. Toxicol Ind Health. 1998 Nov-Dec;14(6):869-89.

This study compared the maternal and fetal effects, including cholinesterase inhibition, following gestational exposure to six organophosphates: tribufos, oxydemeton-methyl, azinphos-methyl, fenamiphos, isofenphos, and fenthion in the Sprague-Dawley rat.
86(1,1,1,6) Details
7097799 Skinner CS, Kilgore WW: Acute dermal toxicities of various organophosphate insecticides in mice. J Toxicol Environ Health. 1982 Mar;9(3):491-7.

Cholinesterase ED50 values roughly agreed with LD50 values for mevinphos, parathion, methyl parathion, and azinphos-methyl, but diazinon appeared much more inhibitory of blood than neuronal cholinesterase.
83(1,1,1,3) Details
11298499 Richardson JR, Chambers HW, Chambers JE: Analysis of the additivity of in vitro inhibition of cholinesterase by mixtures of chlorpyrifos-oxon and azinphos-methyl-oxon. Toxicol Appl Pharmacol. 2001 Apr 15;172(2):128-39.
82(1,1,1,2) Details
10632139 Akgur SA, Ozturk P, Sozmen EY, Delen Y, Tanyalcin T, Ege B: Paraoxonase and acetylcholinesterase activities in humans exposed to organophosphorous compounds. J Toxicol Environ Health A. 1999 Dec 24;58(8):469-74.

Both serum cholinesterase and PON1 activities were measured spectrophotometrically from 18 male agricultural workers who were chronically exposed to azinphos methyl, chlorpyriphos, or malathion and other pesticides during cereal spraying, transportation, and storage.
31(0,1,1,1) Details
17509940 Ferrari A, Venturino A, Pechen de D'Angelo AM: Muscular and brain cholinesterase sensitivities to azinphos methyl and carbaryl in the juvenile rainbow trout Oncorhynchus mykiss. Comp Biochem Physiol C Toxicol Pharmacol. 2007 Sep;146(3):308-13. Epub 2007 Apr 19.
7(0,0,1,2) Details
19362380 Ferrari A, Lascano CI, Anguiano OL, D'Angelo AM, Venturino A: Antioxidant responses to azinphos methyl and carbaryl during the embryonic development of the toad Rhinella (Bufo) arenarum Hensel. Aquat Toxicol. 2009 Jun 4;93(1):37-44. Epub 2009 Mar 24.

We studied the effects of the exposure to two anticholinesterase agents, the carbamate carbaryl and the organophosphate azinphos methyl, on the antioxidant defenses of developing embryos of the toad Rhinella (Bufo) arenarum.
6(0,0,1,1) Details
3629598 Sultatos LG, Minor LD: Metabolic activation of the pesticide azinphos-methyl by perfused mouse livers. Toxicol Appl Pharmacol. 1987 Sep 15;90(2):227-34.

Perfusion of mouse livers in situ with the phosphorodithioate pesticide azinphos-methyl (O,O-dimethyl S-[4-oxo-1,2,3-benzotriazin-3 (4H)-ylmethyl] phosphorodithioate; Guthion) resulted in the appearance of the cholinesterase inhibitor azinphos-methyl oxon in effluent perfusate.
31(0,1,1,1) Details
7097797 Skinner CS, Kilgore WW: Application of a dermal self-exposure model to worker reentry. J Toxicol Environ Health. 1982 Mar;9(3):461-81.

Blood cholinesterases were monitored on d -3 and -1 before exposure and for 4--6 d during exposure to foliar residues.
Azinphos-methyl and mevinphos produced no significant responses in muzzled mice at maximal foliar concentrations.
5(0,0,0,5) Details
9732468 Gruber SJ, Munn MD: Organophosphate and carbamate insecticides in agricultural waters and cholinesterase (ChE) inhibition in common carp (Cyprinus carpio). Arch Environ Contam Toxicol. 1998 Oct;35(3):391-6.

The depressed ChE activity in brain tissue of Royal Lake carp was in response to ChE-inhibiting insecticides detected in water samples in the weeks prior to tissue sampling; the most frequently detected insecticides included chlorpyrifos, azinphos-methyl, carbaryl, and ethoprop.
2(0,0,0,2) Details
19674799 Tryfonos M, Papaefthimiou C, Antonopoulou E, Theophilidis G: Comparing the inhibitory effects of five protoxicant organophosphates (azinphos-methyl, parathion-methyl, chlorpyriphos-methyl, methamidophos and diazinon) on the spontaneously beating auricle of Sparus aurata: an in vitro study. Aquat Toxicol. 2009 Sep 14;94(3):211-8. Epub 2009 Jul 16.

In a previous pilot study, the anticholinesterase effects of paraoxon on the heart of Sparus aurata were examined [Tryfonos, M., Antonopoulou, E., Papaefthimiou, C., Chaleplis, G., Theophilidis, G., 2009.
2(0,0,0,2) Details
11280971 Wilson L, Martin PA, Elliott JE, Mineau P, Cheng KM: Exposure of California quail to organophosphorus insecticides in apple orchards in the Okanagan Valley, British Columbia. Ecotoxicology. 2001 Apr;10(2):79-90.

We studied the exposure and effect of the organophosphate insecticides azinphos-methyl and diazinon on adult California quail (Callipepla californica) in an apple orchard in the Okanagan Valley, British Columbia.
Cholinesterase activity was measured in plasma samples (n = 65) collected from 54 individuals either prior to spraying, immediately (< 24 hours) or 10 days after three spray events.
2(0,0,0,2) Details
7265305 Franklin CA, Fenske RA, Greenhalgh R, Mathieu L, Denley HV, Leffingwell JT, Spear RC: Correlation of urinary pesticide metabolite excretion with estimated dermal contact in the course of occupational exposure to Guthion. J Toxicol Environ Health. 1981 May;7(5):715-31.

Exposure to and absorption of Guthion 50 W.P. (azinphos-methyl) were estimated in orchardists from the Okanagan Valley in British Columbia who were involved in mixing, loading, and application with ultra-low volume air blast equipment.
Air monitoring and patch techniques were used to estimate exposure, and alkyl phosphate excretion and cholinesterase inhibition were measured to estimate absorption.
1(0,0,0,1) Details
9024678 Sheets LP, Hamilton BF, Sangha GK, Thyssen JH: Subchronic neurotoxicity screening studies with six organophosphate insecticides: an assessment of behavior and morphology relative to cholinesterase inhibition. Fundam Appl Toxicol. 1997 Jan;35(1):101-19.

Sulprofos, disulfoton, azinphos-methyl, methamidophos, trichlorfon, and tebupirimphos were screened for neurotoxic potential, in accordance with U.S.
2(0,0,0,2) Details
6619428 Lin SN, Caprioli RM, Murphy SD: Comparison of high-performance liquid chromatography and anticholinesterase assay for measuring azinphos-methyl metabolism in vitro. J Agric Food Chem. 1983 Jul-Aug;31(4):756-9.
1(0,0,0,1) Details
16318873 Reinecke SA, Reinecke AJ: The impact of organophosphate pesticides in orchards on earthworms in the Western Cape, South Africa. Ecotoxicol Environ Saf. 2007 Feb;66(2):244-51. Epub 2005 Nov 28.

Background concentrations of azinphos methyl were higher than those of chlorpyrifos (1.6-9.8 microg/kg) but not detectable 2 weeks after a spraying event.
A microcosm study indicated effects of chlorpyrifos on earthworms as determined by measuring biomass change and Cholinesterase inhibition.
1(0,0,0,1) Details
947316 Kimmerle G: Subchronic inhalation toxicity of azinphos-methyl in rats. Arch Toxicol. 1976 Mar 11;35(2):83-9.

This group showed a significant depression of the cholinesterase activity in plasma and erythrocytes.
1(0,0,0,1) Details
15657813 Gill H, Williams TD, Bishop CA, Cheng KM, Elliott JE: Effects of azinphos-methyl on cholinergic responses and general health in zebra finches (Taeniopygia guttata) after previous treatment with p,p'-DDE. Arch Environ Contam Toxicol. 2005 Jan;48(1):118-26.

Extensive research has been conducted to determine the effects of currently used OPs on cholinesterase (ChE) activity; however, although OCs continue to be prevalent in areas of previous use, few studies have looked at the toxicity of a combination of residual OC compounds with currently used OP pesticides.
1(0,0,0,1) Details
8198427 Meyers SM, Wolff JO: Comparative toxicity of azinphos-methyl to house mice, laboratory mice, deer mice, and gray-tailed voles. Arch Environ Contam Toxicol. 1994 May;26(4):478-82.

All treated animals lost more weight, consumed less food, and had depressed brain cholinesterase (ChE) activity compared to controls.
1(0,0,0,1) Details
1650168 Drevenkar V, Radic Z, Vasilic Z, Reiner E: Dialkylphosphorus metabolites in the urine and activities of esterases in the serum as biochemical indices for human absorption of organophosphorus pesticides. Arch Environ Contam Toxicol. 1991 Apr;20(3):417-22.

Ninety-seven agricultural workers were monitored for absorption of the organophosphorus pesticides methidathion, vamidothion, and azinphos-methyl, which were sprayed in an orchard during two seasons.
This study confirmed that dialkylphosphorus metabolites in the urine are a more sensitive index of absorption than cholinesterase inhibition in the serum but lack of correlation between cholinesterase inhibition and metabolite concentration indicates that both parameters should be monitored.
1(0,0,0,1) Details
10635541 Simcox NJ, Camp J, Kalman D, Stebbins A, Bellamy G, Lee IC, Fenske R: Farmworker exposure to organophosphorus pesticide residues during apple thinning in central Washington State. Am Ind Hyg Assoc J. 1999 Nov-Dec;60(6):752-61.


The purpose of this study was to characterize worker exposure to azinphos-methyl (Guthion) over an entire 4-6 week apple-thinning season.
0(0,0,0,0) Details
15378568 Reuveny H, Cohen E: Evaluation of mechanisms of azinphos-methyl resistance in the codling moth Cydia pomonella (L.). Arch Insect Biochem Physiol. 2004 Oct;57(2):92-100.

0(0,0,0,0) Details
15683833 Ferrari A, Anguiano OL, Soleno J, Venturino A, Pechen de D'Angelo AM: Different susceptibility of two aquatic vertebrates (Oncorhynchus mykiss and Bufo arenarum) to azinphos methyl and carbaryl. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Dec;139(4):239-43.

0(0,0,0,0) Details