Protein Information

Name Telomerase (protein family or complex)
Synonyms Telomerase; Telomerases

Compound Information

Name tetramine
CAS

Reference List

PubMed Abstract RScore(About this table)
18164582 Liu J, Guo L, Yin F, Zheng X, Chen G, Wang Y: Characterization and antitumor activity of triethylene tetramine, a novel telomerase inhibitor. Biomed Pharmacother. 2008 Sep;62(7):480-5. Epub 2007 Dec 17.

Triethylene tetramine (TETA) is a novel ligand for G-quadruplex and has been reported to have many kinds of biological activities, including telomerase inhibition, inducing the senescence of tumor cells, etc.
113(1,2,2,3) Details
17846709 Lixia G, Fei Y, Jiajia J, Jianhui L: Triethylene tetramine, a novel ligand of G-quadruplex, induces senescence of MCF-7 cells. Biotechnol Lett. 2008 Jan;30(1):47-53. Epub 2007 Sep 6.

Interference with telomerase and telomere maintenance is emerging as an attractive target for antitumor therapies.
1(0,0,0,1) Details